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Lorazepam: Difference between revisions
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The [[anticonvulsant]] properties of benzodiazepines may be, in part or entirely, due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors.<ref>Benzodiazepines, but not beta carbolines, limit high frequency repetitive firing of action potentials of spinal cord neurons in cell culture. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/2450203</ref> | The [[anticonvulsant]] properties of benzodiazepines may be, in part or entirely, due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors.<ref>Benzodiazepines, but not beta carbolines, limit high frequency repetitive firing of action potentials of spinal cord neurons in cell culture. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/2450203</ref> | ||
Lorazepam is thought to have a relatively high affinity for [[GABA]] receptors compared to other benzodiazepines, which may also explain its marked amnesic effects.<ref>Benzodiazepine receptors mediate regional blood flow changes in the living human brain. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC42301/</ref> | |||
Lorazepam undergoes | Lorazepam undergoes glucuronidation via Hepatic Pathways which produces lorazepam glucuronide as the main metabolite. The glucuronide attached increases the polarity of the molecule allowing a faster excretion through urine.{{citation needed}} | ||
==Subjective effects== | ==Subjective effects== | ||