DPT: Difference between revisions

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'''N,N-Dipropyltryptamine''' (also known as '''Dipropyltryptamine''', '''DPT''', and '''"The Light"''') is a synthetic [[psychoactive class::psychedelic]] of the [[chemical class::tryptamine]] ~~chemical~~ class that produces ~~powerful, short~~-~~lived~~ visionary [[psychedelic]] effects ~~similar to, but often considered to be more unpredictable and "challenging," than those of [[DMT]]~~ when [[~~Routes of administration|~~administered]]. It is ~~a structural homolog of~~ [[DMT]] ~~that~~ is ~~often~~ reported to be uniquely similar in its [[hallucinogenic]] intensity, albeit with a moderately longer duration and ~~a tendency to feel more "bizarre" and "chaotic", if not "unsettling",~~ relative to DMT and other psychedelic [[tryptamines]].

'''N,N-Dipropyltryptamine''' (also known as '''Dipropyltryptamine''', '''DPT''', and '''"The Light"''') is a synthetic [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] class that produces DMT-like visionary [[psychedelic]] effects when [[administered]]. It is closely related to [[DMT]] and is reported to be uniquely similar in its hallucinogenic intensity, albeit with a moderately longer duration and greater unpredictability relative to DMT and other psychedelic tryptamines.

DPT was first reported in 1973, where it was researched in low doses as an adjunct to therapy for alcoholism.<ref>Grof, S., Soskin, R. A., Richards, W. A., & Kurland, A. A. (1972). DPT as an adjunct in psychotherapy of alcoholics. ''International Pharmacopsychiatry'', 8(1), 104-115. PMID: 4150711</ref> It has also been researched in high doses to induce peak experiences for terminal cancer patients.<ref>Richards, W. A., Rhead, J. C., DiLeo, F. B., Yensen, R., & Kurland, A. A. (1977). The peak experience variable in DPT-assisted psychotherapy with cancer patients. ''Journal of Psychedelic Drugs'', 9(1), 1-10. http://dx.doi.org/10.1080/02791072.1977.10472020</ref> It has gained some notoriety for its adoption as the primary sacrament for the "Temple of the True Inner Light" in the United States, a Christian off-shoot organization who believe in the ritual use of [[psychedelics]] and refer to them as "the true flesh of God."<ref>Temple of the True Inner Light | http://psychede.tripod.com/</ref>

DPT use was first reported in 1973, where it was researched in low doses as an adjunct to therapy for alcoholism.<ref>Grof, S., Soskin, R. A., Richards, W. A., & Kurland, A. A. (1972). DPT as an adjunct in psychotherapy of alcoholics. ''International Pharmacopsychiatry'', 8(1), 104-115. PMID: 4150711</ref> It has also been researched in high doses to induce peak experiences for terminal cancer patients.<ref>Richards, W. A., Rhead, J. C., DiLeo, F. B., Yensen, R., & Kurland, A. A. (1977). The peak experience variable in DPT-assisted psychotherapy with cancer patients. ''Journal of Psychedelic Drugs'', 9(1), 1-10. http://dx.doi.org/10.1080/02791072.1977.10472020</ref> It has gained some notoriety for its adoption as the primary sacrament for the "Temple of the True Inner Light" in the United States, a Christian off-shoot organization who believe in the ritual use of [[psychedelics]] and refer to them as "the true flesh of God."<ref>Temple of the True Inner Light | http://psychede.tripod.com/</ref>

DPT is commonly consumed via [[insufflation]] or [[orally]]. Many report the experience of insufflation to be very congestive and painful which, with the rapidness of onset, does not give the user much time to acclimate themselves to its powerful effects. It can also be administered [[intramuscular|intramuscularly]] or via [[vaporization]] after conversion to the freebase form, and this appears to be the preferred [[Routes of administration|route of administration]] in research settings. Smoking the freebase is reported to be the preferred route used by the "Temple of True Inner Light".{{citation needed}}

Very little data exists about the pharmacological properties, metabolism, and toxicity of DPT, and it has relatively little history of human usage. It has long been available on the [[research chemicals]] market as a legal, grey-market alternative to [[DMT]], and commercially distributed through online vendors. Many reports also suggest that this substance may be overly difficult to use safely for those who are not already very experienced with [[hallucinogens]]. ~~Therefore it~~ is highly advised to approach this ~~unusually~~ powerful [[psychedelic]] substance with the proper amount of precaution and [[Responsible drug use#Hallucinogens|harm reduction practices]] ~~if one chooses to use~~ it.

Very little data exists about the pharmacological properties, metabolism, and toxicity of DPT, and it has relatively little history of human usage. It has long been available on the [[research chemicals]] market as a legal, grey-market alternative to [[DMT]], and commercially distributed through online vendors. Many reports also suggest that this substance may be overly difficult to use safely for those who are not already very experienced with [[hallucinogens]]. It is highly advised to approach this powerful [[psychedelic]] substance with the proper amount of precaution and [[Responsible drug use#Hallucinogens|harm reduction practices]] when using it.

~~==History and culture==~~

~~{{historyStub}}~~

==Chemistry==

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==Pharmacology==

DPT's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub>]] and [[Serotonin#The 5-HT system|5-HT<sub>1A</sub>]] [[receptor]] as a [[Agonist#Agonists|partial agonist]].<ref>William E. Fantegrossi, Chad J. Reissig, Elyse B. Katz, Haley L. Yarosh, Kenner C. Rice, Jerrold C. Winterb. Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents. Pharmacol Biochem Behav. 2008 January; 88(3): 358–365.</ref>

The role of these interactions and how they result in the [[psychedelic]] experience ~~continues to remain~~ subject to ongoing scientific investigation.

The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.

==Subjective effects==

~~{{effectStub}}~~

Relative to psychedelic tryptamines like DMT, DPT is often reported to be similar in its [[hallucinogenic]] intensity, albeit with a moderately longer duration and more challenging effects. DPT experiences are often described as a "bizarre", "unsettling", and "darker" version of DMT experiences. DPT is reported to be more sensual and physical than DMT and other psychedelics with a corresponding amount of adverse physical effects.

At light to moderate doses, users often report a slight sense of anaesthetization and relaxation. As the dose increases, hyper-awareness of one's heart rate and breathing increases and body tremors and loss of muscle control are often reported. The effects of DPT can range from strong euphoria and sensuality to nausea, panic, and intense states dysphoria even within the same experience.

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*'''[[Effect::Excessive yawning]]'''

*'''[[Effect::Pupil dilation]]'''

*'''[[Effect::Increased libido]]'''- This effect appears to occur with more regularity and intensity than other psychedelic tryptamines.

*'''[[Effect::Increased libido]]''' - This effect appears to occur with more regularity and intensity than other psychedelic tryptamines.

}}

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====[[Effect::Geometry]]====

~~The~~ visual geometry ~~of DPT~~ can be described through its variations as intricate in complexity, both abstract and concrete in form, more digital than organic in feel, choppy and only loosely structured in organization, brightly lit, multicolored in scheme, sharp in its edges, fast in speed, simultaneously smooth and glitching in motion, immersive in depth, and consistent in intensity. At higher doses, it is more likely to result in states of [[Effect::8A Geometry|level 8A geometry]] over level 8B.

DPT visual geometry can be described through its variations as intricate in complexity, both abstract and concrete in form, more digital than organic in feel, choppy and only loosely structured in organization, brightly lit, multicolored in scheme, sharp in its edges, fast in speed, simultaneously smooth and glitching in motion, immersive in depth, and consistent in intensity. At higher doses, it is more likely to result in states of [[Effect::8A Geometry|level 8A geometry]] over level 8B.

====Hallucinatory states====

DPT produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of any other commonly used psychedelic barring [[DMT]] and [[~~Ibogaine~~]]. These effects include:

DPT produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of any other commonly used psychedelic barring [[DMT]] and [[ibogaine]]. These effects include:

*'''[[Effect::Transformations]]'''

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==Toxicity and harm potential==

{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}

The toxicity and long-term health effects of recreational DPT do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because DPT is a [[research chemical]] with very little history of human usage.

@@ Line 2: / Line 2: @@
 {{SubstanceBox/DPT}}
-'''N,N-Dipropyltryptamine''' (also known as '''Dipropyltryptamine''', '''DPT''',  and '''"The Light"''') is a synthetic [[psychoactive class::psychedelic]] of the [[chemical class::tryptamine]] chemical class that produces powerful, short-lived visionary [[psychedelic]] effects similar to, but often considered to be more unpredictable and "challenging," than those of [[DMT]] when [[Routes of administration|administered]]. It is a structural homolog of [[DMT]] that is often reported to be uniquely similar in its [[hallucinogenic]] intensity, albeit with a moderately longer duration and a tendency to feel more "bizarre" and "chaotic", if not "unsettling", relative to DMT and other psychedelic [[tryptamines]].
+'''N,N-Dipropyltryptamine''' (also known as '''Dipropyltryptamine''', '''DPT''',  and '''"The Light"''') is a synthetic [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] class that produces DMT-like visionary [[psychedelic]] effects when [[administered]]. It is closely related to [[DMT]] and is reported to be uniquely similar in its hallucinogenic intensity, albeit with a moderately longer duration and greater unpredictability relative to DMT and other psychedelic tryptamines.
-DPT was first reported in 1973, where it was researched in low doses as an adjunct to therapy for alcoholism.<ref>Grof, S., Soskin, R. A., Richards, W. A., & Kurland, A. A. (1972). DPT as an adjunct in psychotherapy of alcoholics. ''International Pharmacopsychiatry'', 8(1), 104-115. PMID: 4150711</ref> It has also been researched in high doses to induce peak experiences for terminal cancer patients.<ref>Richards, W. A., Rhead, J. C., DiLeo, F. B., Yensen, R., & Kurland, A. A. (1977). The peak experience variable in DPT-assisted psychotherapy with cancer patients. ''Journal of Psychedelic Drugs'', 9(1), 1-10. http://dx.doi.org/10.1080/02791072.1977.10472020</ref> It has gained some notoriety for its adoption as the primary sacrament for the "Temple of the True Inner Light" in the United States, a Christian off-shoot organization who believe in the ritual use of [[psychedelics]] and refer to them as "the true flesh of God."<ref>Temple of the True Inner Light | http://psychede.tripod.com/</ref>
+DPT use was first reported in 1973, where it was researched in low doses as an adjunct to therapy for alcoholism.<ref>Grof, S., Soskin, R. A., Richards, W. A., & Kurland, A. A. (1972). DPT as an adjunct in psychotherapy of alcoholics. ''International Pharmacopsychiatry'', 8(1), 104-115. PMID: 4150711</ref> It has also been researched in high doses to induce peak experiences for terminal cancer patients.<ref>Richards, W. A., Rhead, J. C., DiLeo, F. B., Yensen, R., & Kurland, A. A. (1977). The peak experience variable in DPT-assisted psychotherapy with cancer patients. ''Journal of Psychedelic Drugs'', 9(1), 1-10. http://dx.doi.org/10.1080/02791072.1977.10472020</ref> It has gained some notoriety for its adoption as the primary sacrament for the "Temple of the True Inner Light" in the United States, a Christian off-shoot organization who believe in the ritual use of [[psychedelics]] and refer to them as "the true flesh of God."<ref>Temple of the True Inner Light | http://psychede.tripod.com/</ref>
 DPT is commonly consumed via [[insufflation]] or [[orally]]. Many report the experience of insufflation to be very congestive and painful which, with the rapidness of onset, does not give the user much time to acclimate themselves to its powerful effects. It can also be administered [[intramuscular|intramuscularly]] or via [[vaporization]] after conversion to the freebase form, and this appears to be the preferred [[Routes of administration|route of administration]] in research settings. Smoking the freebase is reported to be the preferred route used by the "Temple of True Inner Light".{{citation needed}}
-Very little data exists about the pharmacological properties, metabolism, and toxicity of DPT, and it has relatively little history of human usage. It has long been available on the [[research chemicals]] market as a legal, grey-market alternative to [[DMT]], and commercially distributed through online vendors. Many reports also suggest that this substance may be overly difficult to use safely for those who are not already very experienced with [[hallucinogens]]. Therefore it is highly advised to approach this unusually powerful [[psychedelic]] substance with the proper amount of precaution and [[Responsible drug use#Hallucinogens|harm reduction practices]] if one chooses to use it.
+Very little data exists about the pharmacological properties, metabolism, and toxicity of DPT, and it has relatively little history of human usage. It has long been available on the [[research chemicals]] market as a legal, grey-market alternative to [[DMT]], and commercially distributed through online vendors. Many reports also suggest that this substance may be overly difficult to use safely for those who are not already very experienced with [[hallucinogens]]. It is highly advised to approach this powerful [[psychedelic]] substance with the proper amount of precaution and [[Responsible drug use#Hallucinogens|harm reduction practices]] when using it.
-==History and culture==
-{{historyStub}}
 ==Chemistry==
@@ Line 19: / Line 16: @@
 ==Pharmacology==
+{{pharmacology}}
 {{Further|Serotonergic psychedelic}}
 DPT's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub>]] and [[Serotonin#The 5-HT system|5-HT<sub>1A</sub>]] [[receptor]] as a [[Agonist#Agonists|partial agonist]].<ref>William E. Fantegrossi, Chad J. Reissig, Elyse B. Katz, Haley L. Yarosh, Kenner C. Rice, Jerrold C. Winterb. Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents. Pharmacol Biochem Behav. 2008 January; 88(3): 358–365.</ref>
-The role of these interactions and how they result in the [[psychedelic]] experience continues to remain subject to ongoing scientific investigation.
+The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.
 ==Subjective effects==
-{{effectStub}}
+Relative to psychedelic tryptamines like DMT, DPT is often reported to be similar in its [[hallucinogenic]] intensity, albeit with a moderately longer duration and more challenging effects. DPT experiences are often described as a "bizarre", "unsettling", and "darker" version of DMT experiences. DPT is reported to be more sensual and physical than DMT and other psychedelics with a corresponding amount of adverse physical effects.
 At light to moderate doses, users often report a slight sense of anaesthetization and relaxation. As the dose increases, hyper-awareness of one's heart rate and breathing increases and body tremors and loss of muscle control are often reported. The effects of DPT can range from strong euphoria and sensuality to nausea, panic, and intense states dysphoria even within the same experience.
@@ Line 46: / Line 45: @@
 *'''[[Effect::Excessive yawning]]'''
 *'''[[Effect::Pupil dilation]]'''
-*'''[[Effect::Increased libido]]'''- This effect appears to occur with more regularity and intensity than other psychedelic tryptamines.
+*'''[[Effect::Increased libido]]''' - This effect appears to occur with more regularity and intensity than other psychedelic tryptamines.
 }}
@@ Line 69: / Line 68: @@
 ====[[Effect::Geometry]]====
-The visual geometry of DPT can be described through its variations as intricate in complexity, both abstract and concrete in form, more digital than organic in feel, choppy and only loosely structured in organization, brightly lit, multicolored in scheme, sharp in its edges, fast in speed, simultaneously smooth and glitching in motion, immersive in depth, and consistent in intensity. At higher doses, it is more likely to result in states of  [[Effect::8A Geometry|level 8A geometry]] over level 8B.
+DPT visual geometry can be described through its variations as intricate in complexity, both abstract and concrete in form, more digital than organic in feel, choppy and only loosely structured in organization, brightly lit, multicolored in scheme, sharp in its edges, fast in speed, simultaneously smooth and glitching in motion, immersive in depth, and consistent in intensity. At higher doses, it is more likely to result in states of  [[Effect::8A Geometry|level 8A geometry]] over level 8B.
 ====Hallucinatory states====
-DPT produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of any other commonly used psychedelic barring [[DMT]] and [[Ibogaine]]. These effects include:
+DPT produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of any other commonly used psychedelic barring [[DMT]] and [[ibogaine]]. These effects include:
 *'''[[Effect::Transformations]]'''
@@ Line 134: / Line 133: @@
 ==Toxicity and harm potential==
+{{toxicity}}
 {{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
 The toxicity and long-term health effects of recreational DPT do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because DPT is a [[research chemical]] with very little history of human usage.