Theanine: Difference between revisions

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'''Theanine''' (also known as '''L-Theanine''', '''L-γ-glutamylethylamide''' and '''N5-ethyl-L-glutamine''') is an analog of the amino acids of [[glutamate]] and glutamine. It was discovered as a constituent of green tea in 1949 and in 1950 was isolated from gyokuro leaves, which have high theanine content.<ref>Components of Gyokuro | http://www.ippodo-tea.co.jp/en/tea/gyokuro_02.html</ref>

'''L-Theanine''' (also known as '''Theanine''', '''L-γ-glutamylethylamide''' and '''N5-ethyl-L-glutamine''') is an analog of the amino acids of [[glutamate]] and glutamine. It was discovered as a constituent of green tea in 1949 and in 1950 was isolated from gyokuro leaves, which have high theanine content.<ref>Components of Gyokuro | http://www.ippodo-tea.co.jp/en/tea/gyokuro_02.html</ref>

The appearance of the name "theanine" without a prefix is understood to imply the L-[[enantiomer]], which is the form found in fresh teas and in some, but not all dietary supplements. The opposite D-enantiomer has far less studied pharmacologic properties, but is present in racemic chemical preparations, and substantially in some studied theanine supplements.

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*'''[[Effect::Focus enhancement]]'''

*'''[[Effect::Motivation enhancement]]'''

}}

==Toxicity and harm potential==

Theanine is non-addictive, is not known to cause brain damage, and has an [[Toxicity::extremely low toxicity]] relative to dose.{{citation needed}} ~~Similar to many other [[nootropics]] drugs, there~~ are relatively few physical side effects associated with acute theanine exposure. Various studies have shown that in reasonable doses in a careful context, it presents no negative cognitive, psychiatric or toxic physical consequences ~~of any sort~~.{{citation needed}}

Theanine is non-addictive, is not known to cause brain damage, and has an [[Toxicity::extremely low toxicity]] relative to dose.{{citation needed}} There are relatively few physical side effects associated with acute theanine exposure. Various studies have shown that in reasonable doses in a careful context, it presents no negative cognitive, psychiatric or toxic physical consequences.{{citation needed}}

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this ~~drug~~.

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.

===Tolerance and addiction potential===

Theanine is [[Addiction potential::not habit-forming]] ~~and the desire to use it can actually decrease with use~~.~~{{citation needed}} It is most often self-regulating.{{citation needed}}~~

Theanine is [[Addiction potential::not habit-forming]].

Tolerance to the effects of theanine are built up [[Time to full tolerance::after prolonged and repeated usage]]. It takes about [[Time to half tolerance::5 days]] for tolerance to be reduced by half and [[Time to zero tolerance::10 days]] return to baseline. Theanine presents cross-tolerance with [[Cross-tolerance::no other known compounds]], meaning that after the consumption of theanine all other psychoactive compounds will not have a reduced effect.

Tolerance to the effects of theanine are built up [[Time to full tolerance::after prolonged and repeated usage]]. After noticeable tolerance has been built, it takes about [[Time to half tolerance::5 days]] for tolerance to be reduced by half and [[Time to zero tolerance::10 days]] return to baseline. Theanine presents cross-tolerance with [[Cross-tolerance::no other known compounds]], meaning that after the consumption of theanine all other psychoactive compounds will not have a reduced effect.

==~~Legality~~==

==Legal status==

Theanine is freely available to possess and distribute and is approved in most countries as a dietary supplement.

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 {{SubstanceBox/Theanine}}
-'''Theanine''' (also known as '''L-Theanine''', '''L-γ-glutamylethylamide''' and '''N5-ethyl-L-glutamine''') is an analog of the amino acids of [[glutamate]] and glutamine. It was discovered as a constituent of green tea in 1949 and in 1950 was isolated from gyokuro leaves, which have high theanine content.<ref>Components of Gyokuro | http://www.ippodo-tea.co.jp/en/tea/gyokuro_02.html</ref>
+'''L-Theanine''' (also known as '''Theanine''', '''L-γ-glutamylethylamide''' and '''N5-ethyl-L-glutamine''') is an analog of the amino acids of [[glutamate]] and glutamine. It was discovered as a constituent of green tea in 1949 and in 1950 was isolated from gyokuro leaves, which have high theanine content.<ref>Components of Gyokuro | http://www.ippodo-tea.co.jp/en/tea/gyokuro_02.html</ref>
 The appearance of the name "theanine" without a prefix is understood to imply the L-[[enantiomer]], which is the form found in fresh teas and in some, but not all dietary supplements. The opposite D-enantiomer has far less studied pharmacologic properties, but is present in racemic chemical preparations, and substantially in some studied theanine supplements.
@@ Line 40: / Line 40: @@
 *'''[[Effect::Focus enhancement]]'''
 *'''[[Effect::Motivation enhancement]]'''
 }}
 }}
 ==Toxicity and harm potential==
-Theanine is non-addictive, is not known to cause brain damage, and has an [[Toxicity::extremely low toxicity]] relative to dose.{{citation needed}} Similar to many other [[nootropics]] drugs, there are relatively few physical side effects associated with acute theanine exposure. Various studies have shown that in reasonable doses in a careful context, it presents no negative cognitive, psychiatric or toxic physical consequences of any sort.{{citation needed}}
+Theanine is non-addictive, is not known to cause brain damage, and has an [[Toxicity::extremely low toxicity]] relative to dose.{{citation needed}} There are relatively few physical side effects associated with acute theanine exposure. Various studies have shown that in reasonable doses in a careful context, it presents no negative cognitive, psychiatric or toxic physical consequences.{{citation needed}}
-It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
+It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
 ===Tolerance and addiction potential===
-Theanine is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use.{{citation needed}} It is most often self-regulating.{{citation needed}}
+Theanine is [[Addiction potential::not habit-forming]].
-Tolerance to the effects of theanine are built up [[Time to full tolerance::after prolonged and repeated usage]].             It takes about [[Time to half tolerance::5 days]] for tolerance to be reduced by half and [[Time to zero tolerance::10 days]] return to baseline. Theanine presents cross-tolerance with [[Cross-tolerance::no other known compounds]], meaning that after the consumption of theanine all other psychoactive compounds will not have a reduced effect.
+Tolerance to the effects of theanine are built up [[Time to full tolerance::after prolonged and repeated usage]]. After noticeable tolerance has been built, it takes about [[Time to half tolerance::5 days]] for tolerance to be reduced by half and [[Time to zero tolerance::10 days]] return to baseline. Theanine presents cross-tolerance with [[Cross-tolerance::no other known compounds]], meaning that after the consumption of theanine all other psychoactive compounds will not have a reduced effect.
-==Legality==
+==Legal status==
 {{LegalStub}}
 Theanine is freely available to possess and distribute and is approved in most countries as a dietary supplement.