Lorazepam: Difference between revisions

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The [[anticonvulsant]] properties of benzodiazepines may be, in part or entirely, due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors.<ref>Benzodiazepines, but not beta carbolines, limit high frequency repetitive firing of action potentials of spinal cord neurons in cell culture. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/2450203</ref>

Relative to other [[benzodiazepines]], lorazepam is thought to have high affinity for [[GABA]] receptors, which may also explain its marked amnesic effects.<ref>Benzodiazepine receptors mediate regional blood flow changes in the living human brain. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC42301/</ref>

Lorazepam undergoes Glucuronidation via Hepatic Pathways which produces Lorazepam Glucuronide as the main metabolite. The Glucuronide attached increases the polarity of the molecule allowing a faster excretion through urine.

==Subjective effects==

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 The [[anticonvulsant]] properties of benzodiazepines may be, in part or entirely, due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors.<ref>Benzodiazepines, but not beta carbolines, limit high frequency repetitive firing of action potentials of spinal cord neurons in cell culture. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/2450203</ref>
 Relative to other [[benzodiazepines]], lorazepam is thought to have high affinity for [[GABA]] receptors, which may also explain its marked amnesic effects.<ref>Benzodiazepine receptors mediate regional blood flow changes in the living human brain. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC42301/</ref>
+Lorazepam undergoes Glucuronidation via Hepatic Pathways which produces Lorazepam Glucuronide as the main metabolite. The Glucuronide attached increases the polarity of the molecule allowing a faster excretion through urine.
 ==Subjective effects==