Serotonin: Difference between revisions

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{{headerpanel|{{stub}}}}

[[File:Serotonin.svg|300px|thumb|right|Skeletal formula of a serotonin molecule.]]

'''Serotonin''', also known as '''5-hydroxytryptamine''' ('''5-HT'''), is a [[monoamine]] [[neurotransmitter|neurotransmitter]] affecting the [[serotonin]] [[receptors]] (5-HT<sub>1-7</sub>). Serotonin is primarily found in the gastrointestinal tract, platelets, and in the central nervous system of animals including humans. It is popularly thought to be a contributor to feelings of well-being and happiness.~~{{citation needed}}~~

'''Serotonin''' (also known as '''5-hydroxytryptamine''', or '''5-HT'''), is a [[monoamine]] [[neurotransmitter|neurotransmitter]] affecting the [[serotonin]] [[receptors]] (5-HT<sub>1-7</sub>). Serotonin is primarily found in the gastrointestinal tract, platelets, and in the central nervous system of animals including humans.{{citation needed}} It is popularly thought to be a contributor to feelings of well-being and happiness.

Approximately 90% of the human body's total serotonin is located in the digestive system, where it is used to regulate intestinal movements. The remainder is synthesized in serotonergic [[neurons]] of the CNS, where it has various functions. These include the regulation of mood, appetite, heart rate and sleep.{{citation needed}}

Approximately 90% of the human body's total serotonin is located in the digestive system, where it is used to regulate intestinal movements.{{citation needed}} The remainder is synthesized in serotonergic [[neurons]] of the CNS, where it has various functions. These include the regulation of mood, appetite, heart rate and sleep.{{citation needed}}

Serotonin also has some cognitive functions, including memory and learning. In the blood, it serves as a [[vasoconstriction|vasoconstrictor]], and could be attributed as the cause of vasoconstriction in most serotonergic drugs.{{citation needed}}

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*[https://en.wikipedia.org/wiki/Tryptophan Tryptophan (Wikipedia)]

*[https://en.wikipedia.org/wiki/5-Hydroxytryptophan 5-Hydroxytryptophan (Wikipedia)]

==Literature==

*Sodhi, M., & Sanders-Bush, E. (2004). Serotonin and brain development. International Review of Neurobiology, 59, 111-74. https://doi.org/10.1016/S0074-7742(04)59006-2

*Nichols, D.E., & Nichols, C.D. (2008). Serotonin receptors. Chemical Reviews, 108 5, 1614-41. https://doi.org/10.1021/cr078224o

*Berger, M., Gray, J.A., & Roth, B.L. (2009). The expanded biology of serotonin. Annual Review of Medicine, 60, 355-66. https://doi.org/10.1146/annurev.med.60.042307.110802

*Aghajanian, G., & Marek, G. (1999). Serotonin and Hallucinogens. Neuropsychopharmacology, 21, 16S-23S. https://doi.org/10.1016/S0893-133X(98)00135-3

==References==

@@ Line 1: / Line 1: @@
 {{headerpanel|{{stub}}}}
 [[File:Serotonin.svg|300px|thumb|right|Skeletal formula of a serotonin molecule.]]
-'''Serotonin''', also known as '''5-hydroxytryptamine''' ('''5-HT'''), is a [[monoamine]] [[neurotransmitter|neurotransmitter]] affecting the [[serotonin]] [[receptors]] (5-HT<sub>1-7</sub>). Serotonin is primarily found in the gastrointestinal tract, platelets, and in the central nervous system of animals including humans. It is popularly thought to be a contributor to feelings of well-being and happiness.{{citation needed}}
+'''Serotonin''' (also known as '''5-hydroxytryptamine''', or '''5-HT'''), is a [[monoamine]] [[neurotransmitter|neurotransmitter]] affecting the [[serotonin]] [[receptors]] (5-HT<sub>1-7</sub>). Serotonin is primarily found in the gastrointestinal tract, platelets, and in the central nervous system of animals including humans.{{citation needed}} It is popularly thought to be a contributor to feelings of well-being and happiness.
-Approximately 90% of the human body's total serotonin is located in the digestive system, where it is used to regulate intestinal movements. The remainder is synthesized in serotonergic [[neurons]] of the CNS, where it has various functions. These include the regulation of mood, appetite, heart rate and sleep.{{citation needed}}
+Approximately 90% of the human body's total serotonin is located in the digestive system, where it is used to regulate intestinal movements.{{citation needed}} The remainder is synthesized in serotonergic [[neurons]] of the CNS, where it has various functions. These include the regulation of mood, appetite, heart rate and sleep.{{citation needed}}
 Serotonin also has some cognitive functions, including memory and learning. In the blood, it serves as a [[vasoconstriction|vasoconstrictor]], and could be attributed as the cause of vasoconstriction in most serotonergic drugs.{{citation needed}}
@@ Line 69: / Line 69: @@
 *[https://en.wikipedia.org/wiki/Tryptophan Tryptophan (Wikipedia)]
 *[https://en.wikipedia.org/wiki/5-Hydroxytryptophan 5-Hydroxytryptophan (Wikipedia)]
+==Literature==
+*Sodhi, M., & Sanders-Bush, E. (2004). Serotonin and brain development. International Review of Neurobiology, 59, 111-74. https://doi.org/10.1016/S0074-7742(04)59006-2
+*Nichols, D.E., & Nichols, C.D. (2008). Serotonin receptors. Chemical Reviews, 108 5, 1614-41. https://doi.org/10.1021/cr078224o
+*Berger, M., Gray, J.A., & Roth, B.L. (2009). The expanded biology of serotonin. Annual Review of Medicine, 60, 355-66. https://doi.org/10.1146/annurev.med.60.042307.110802
+*Aghajanian, G., & Marek, G. (1999). Serotonin and Hallucinogens. Neuropsychopharmacology, 21, 16S-23S. https://doi.org/10.1016/S0893-133X(98)00135-3
 ==References==