3-HO-PCE: Difference between revisions

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Following other substances of its class, particularly [[methoxetamine]] (MXE), [[phencyclidine]] (PCP), and [[3-MeO-PCE]], it is speculated to to be able to induce a state known as "[[dissociatives#Subjective effects|dissociative anesthesia]]". Early reports suggest that this state is difficult to reach relative to other [[dissociatives]], and its general effects profile has been characterized as "lying halfway between [[3-MeO-PCP]] and [[3-MeO-PCE]]."

Research surrounding 3-HO-PCE sold on ~~the~~ grey market is almost entirely speculative. As phencyclidines such as [[PCP]] have been found unlikely to produce metabolites such as [[3-HO-PCP]] to date, it is it unlikely that [[3-HO-PCE]] would be a natural metabolite from the use of [[PCE]] in the human body. <refname="https://academic.oup.com/jat/article-abstract/10/3/107/722949?redirectedFrom=fulltext" />

Research surrounding 3-HO-PCE sold on grey market is almost entirely speculative. As phencyclidines such as [[PCP]] have been found unlikely to produce metabolites such as [[3-HO-PCP]] to date, it is it unlikely that [[3-HO-PCE]] would be a natural metabolite from the use of [[PCE]] in the human body. <refname=Metabolism/>

"https://academic.oup.com/jat/article-abstract/10/3/107/722949?redirectedFrom=fulltext" />

As with many ~~similar~~ eticyclidines, there is a lack of data on ~~the~~ pharmacological properties and toxicity of 3-HO-PCE, ~~because of its brief history of human usage. There~~ have been no analytical studies conducted on samples of 3-HO-PCE distributed through the grey market via independent laboratories.<ref name="PCP2MXE /> Due to an unknown toxicity profile and likely similar habit-forming properties shared by other hydroxylanated arylcyclohexylamines, it is strongly recommended that one use proper [[harm reduction practices]] if choosing to use this substance.

As with many novel eticyclidines, there is a lack of data on its pharmacological properties and toxicity of 3-HO-PCE. To date, there have been no analytical studies conducted on samples of 3-HO-PCE distributed through the grey market via independent laboratories.<ref name="PCP2MXE /> Due to an unknown toxicity profile and likely similar habit-forming properties shared by other hydroxylanated arylcyclohexylamines, it is strongly recommended that one use proper [[harm reduction practices]] if choosing to use this substance.

==History and culture==

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 Following other substances of its class, particularly [[methoxetamine]] (MXE), [[phencyclidine]] (PCP), and [[3-MeO-PCE]], it is speculated to to be able to induce a state known as "[[dissociatives#Subjective effects|dissociative anesthesia]]". Early reports suggest that this state is difficult to reach relative to other [[dissociatives]], and its general effects profile has been characterized as "lying halfway between [[3-MeO-PCP]] and [[3-MeO-PCE]]."
-Research surrounding 3-HO-PCE sold on the grey market is almost entirely speculative. As phencyclidines such as [[PCP]] have been found unlikely to produce metabolites such as [[3-HO-PCP]] to date, it is it unlikely that [[3-HO-PCE]] would be a natural metabolite from the use of [[PCE]] in the human body. <refname="https://academic.oup.com/jat/article-abstract/10/3/107/722949?redirectedFrom=fulltext" />
+Research surrounding 3-HO-PCE sold on grey market is almost entirely speculative. As phencyclidines such as [[PCP]] have been found unlikely to produce metabolites such as [[3-HO-PCP]] to date, it is it unlikely that [[3-HO-PCE]] would be a natural metabolite from the use of [[PCE]] in the human body. <refname=Metabolism/>
+"https://academic.oup.com/jat/article-abstract/10/3/107/722949?redirectedFrom=fulltext" />
-As with many similar eticyclidines, there is a lack of data on the pharmacological properties and toxicity of 3-HO-PCE, because of its brief history of human usage. There have been no analytical studies conducted on samples of 3-HO-PCE distributed through the grey market via independent laboratories.<ref name="PCP2MXE /> Due to an unknown toxicity profile and likely similar habit-forming properties shared by other hydroxylanated arylcyclohexylamines, it is strongly recommended that one use proper [[harm reduction practices]] if choosing to use this substance.
+As with many novel eticyclidines, there is a lack of data on its pharmacological properties and toxicity of 3-HO-PCE. To date, there have been no analytical studies conducted on samples of 3-HO-PCE distributed through the grey market via independent laboratories.<ref name="PCP2MXE /> Due to an unknown toxicity profile and likely similar habit-forming properties shared by other hydroxylanated arylcyclohexylamines, it is strongly recommended that one use proper [[harm reduction practices]] if choosing to use this substance.
 ==History and culture==