2C-H: Difference between revisions

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'''2,5-Dimethoxyphenethylamine''' (also known as '''2C-H''' and '''DMPEA''') is a lesser-known [[~~substituted~~ phenethylamine]] that is the ~~traditional precursor to~~ [[2C-B]], [[2C-~~C]] and [[~~2C-I~~]]. It was first synthesized in 1932 by Johannes S. Buck~~ and ~~was later studied in the 1970s by [[Alexander Shulgin]], who published his findings in his book [[PiHKAL]]~~.

'''2,5-Dimethoxyphenethylamine''' (also known as '''2C-H''' and '''DMPEA''') is a lesser-known psychoactive substance of the [[chemical class::phenethylamine]] class that belongs to the [[2C-x]] family of substituted phenethylamines. Lacking significant psychedelic effects, it is primarily used as a precursor in the synthesis of other phenethylamines such as 2C-B, 2C-I, and 2C-N.

Shulgin lists both the dosage and duration as unknown, as 2C-H is likely easily broken down by ~~the~~ MAO ~~enzyme~~ in the liver and is thus ~~considered~~ probably inactive. However, there ~~are~~ some anecdotal reports ~~online suggesting~~ that it may be active when taken [[~~sublingual~~]]ly.<ref>So Happy, Very Happy 2C-H by PandaDoom (Erowid) | https://erowid.org/experiences/exp.php?ID=80334</ref> ~~When combined~~ with an [[MAOI]], it ~~may be~~ [[~~oral~~]]~~ly active~~.

2C-H was first synthesized in 1932 by Johannes S. Buck<ref>Buck, J. S. (1932). HYDROXY-AND DIHYDROXYPHENYLETHYLMETHYLAMINES AND THEIR ETHERS. Journal of the American Chemical Society, 54(9), 3661-3665. https://doi.org/10.1021/ja01348a024.</ref> and its effects in humans were explored in the 1970s by [[Alexander Shulgin]], who published his findings in the book [[PiHKAL|PiHKAL (Phenethylamines I Have Known and Loved)]].

In PiHKAL, Shulgin lists both the dosage and duration as unknown, commenting that 2C-H is likely easily broken down by MAO enzymes in the liver and is thus probably inactive. However, there have since been some anecdotal reports that suggest it may be active when taken [[sublingually]].<ref>So Happy, Very Happy 2C-H by PandaDoom (Erowid) | https://erowid.org/experiences/exp.php?ID=80334</ref> It is theorized to be [[orally]] active if taken in combination with a [[MAOI]]. However, it is unknown whether this would result in typical 2C-x psychedelic effects.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-H. It is highly advised to use [[harm reduction practices]] when using this substance.

==Chemistry==

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 {{SubstanceBox/2C-H}}
-'''2,5-Dimethoxyphenethylamine''' (also known as '''2C-H''' and '''DMPEA''') is a lesser-known [[substituted phenethylamine]] that is the traditional precursor to [[2C-B]], [[2C-C]] and [[2C-I]]. It was first synthesized in 1932 by Johannes S. Buck and was later studied in the 1970s by [[Alexander Shulgin]], who published his findings in his book [[PiHKAL]].
+'''2,5-Dimethoxyphenethylamine''' (also known as '''2C-H''' and '''DMPEA''') is a lesser-known psychoactive substance of the [[chemical class::phenethylamine]] class that belongs to the [[2C-x]] family of substituted phenethylamines. Lacking significant psychedelic effects, it is primarily used as a precursor in the synthesis of other phenethylamines such as 2C-B, 2C-I, and 2C-N.
-Shulgin lists both the dosage and duration as unknown, as 2C-H is likely easily broken down by the MAO enzyme in the liver and is thus considered probably inactive. However, there are some anecdotal reports online suggesting that it may be active when taken [[sublingual]]ly.<ref>So Happy, Very Happy 2C-H by PandaDoom (Erowid) | https://erowid.org/experiences/exp.php?ID=80334</ref> When combined with an [[MAOI]], it may be [[oral]]ly active.
+C-H was first synthesized in 1932 by Johannes S. Buck<ref>Buck, J. S. (1932). HYDROXY-AND DIHYDROXYPHENYLETHYLMETHYLAMINES AND THEIR ETHERS. Journal of the American Chemical Society, 54(9), 3661-3665. https://doi.org/10.1021/ja01348a024.</ref> and its effects in humans were explored in the 1970s by [[Alexander Shulgin]], who published his findings in the book [[PiHKAL|PiHKAL (Phenethylamines I Have Known and Loved)]].
+In PiHKAL, Shulgin lists both the dosage and duration as unknown, commenting that 2C-H is likely easily broken down by MAO enzymes in the liver and is thus probably inactive. However, there have since been some anecdotal reports that suggest it may be active when taken [[sublingually]].<ref>So Happy, Very Happy 2C-H by PandaDoom (Erowid) | https://erowid.org/experiences/exp.php?ID=80334</ref> It is theorized to be [[orally]] active if taken in combination with a [[MAOI]]. However, it is unknown whether this would result in typical 2C-x psychedelic effects.
+Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-H. It is highly advised to use [[harm reduction practices]] when using this substance.
 ==Chemistry==