This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
5-Hydroxytryptophan: Difference between revisions
>Cannabis Entity Grammatics |
>Ayylmaonade m Adding EGCG as a way to protect the heart from 5-HTP. |
||
| Line 68: | Line 68: | ||
}} | }} | ||
==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
Due to the conversion of 5-HTP into serotonin by the liver, with prolonged use, there may be a significant risk of heart valve disease from serotonin's effect on the heart, which is thought to be due to agonism of the 5-HT<sub>2B</sub> receptors present on it.<ref>https://www.ncbi.nlm.nih.gov/pubmed/15781732 | Long-term serotonin administration induces heart valve disease in rats.</ref><ref>https://www.ncbi.nlm.nih.gov/pubmed/12466135 | Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells.</ref> | Due to the conversion of 5-HTP into serotonin by the liver, with prolonged use, there may be a significant risk of heart valve disease from serotonin's effect on the heart, which is thought to be due to agonism of the 5-HT<sub>2B</sub> receptors present on it.<ref>https://www.ncbi.nlm.nih.gov/pubmed/15781732 | Long-term serotonin administration induces heart valve disease in rats.</ref><ref>https://www.ncbi.nlm.nih.gov/pubmed/12466135 | Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells.</ref> However, this may be avoided if Epigallocatechin gallate (more well known as 'EGCG') is taken before the 5-HTP. This is said to protect the heart, and therefore reduce the risks of any heart damage.<ref>https://www.ncbi.nlm.nih.gov/pubmed/27374189 | EGCG, a green tea catechin, attenuates the progression of heart failure induced by the heart/muscle-specific deletion of MnSOD in mice.</ref><ref>https://www.ncbi.nlm.nih.gov/pubmed/17906191 | Effects of green tea and EGCG on cardiovascular and metabolic health.</ref> | ||
It has been suggested that 5-HTP may cause eosinophilia-myalgia syndrome (EMS), a serious condition which results in extreme muscle tenderness, myalgia, and blood abnormalities. However, there is evidence to show that EMS was likely caused by a contaminant in certain 5-HTP supplements instead of the substance itself.<ref>https://www.ncbi.nlm.nih.gov/pubmed/7699627 | An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan.</ref> | It has been suggested that 5-HTP may cause eosinophilia-myalgia syndrome (EMS), a serious condition which results in extreme muscle tenderness, myalgia, and blood abnormalities. However, there is evidence to show that EMS was likely caused by a contaminant in certain 5-HTP supplements instead of the substance itself.<ref>https://www.ncbi.nlm.nih.gov/pubmed/7699627 | An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan.</ref> | ||