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Talk:Antidepressant: Difference between revisions
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==Types of antidepressants== | ==Types of antidepressants== | ||
===Serotonin reuptake inhibitors=== | |||
[[Dextromethorphan]]<ref>http://www.sciencedirect.com/science/article/pii/S0306987711000545</ref> | [[Dextromethorphan]]<ref>http://www.sciencedirect.com/science/article/pii/S0306987711000545</ref> | ||
Because dextromethorphan can show similar antidepressant effects to ketamine in threshold and light dosages, it is possible that dextromethorphan could be a possible treatment for treatment resistant and severe depression. Many users of dextromethorphan | Because dextromethorphan can show similar antidepressant effects to ketamine in threshold and light dosages, it is possible that dextromethorphan could be a possible treatment for treatment resistant and severe depression. Many users claim that a single use of dextromethorphan alleviates their depression for up to a week.{{citation needed}} This may be a related to its activity as a reuptake inhibitor of serotonin. However, it is believed to have neurotoxic properties so its routine use as an antidepressant is not advised. | ||
===Selective serotonin reuptake inhibitors ([[SSRIs]])=== | |||
Selective serotonin reuptake inhibitors are believed to increase the level of extracellular [[serotonin]], therefore allowing more serotonin to be in the brain. The reason SSRIs are used for depression is that the serotonin hypothesis, one of the most commonly accepted theories for depression, states that low serotonin in the brain causes depression. SSRIs are the most commonly prescribed antidepressant, and the most commonly prescribed anxiolytic for children. They are also the first-line treatment for panic disorder, not benzodiazepines like lorazepam and alprazolam. | |||
===Serotonin-norepinephrine reuptake inhibitor (SNRIs)=== | |||
Serotonin-norepinephrine reuptake inhibitors increase the level of extracellular [[serotonin]] and [[norepinephrine]], allowing more of the neurotransmitters to be in the brain. SNRIs are used for depression because the serotonin hypothesis states that low serotonin in the brain causes depression, and also to treat tiredness commonly experienced with depression. | Serotonin-norepinephrine reuptake inhibitors increase the level of extracellular [[serotonin]] and [[norepinephrine]], allowing more of the neurotransmitters to be in the brain. SNRIs are used for depression because the serotonin hypothesis states that low serotonin in the brain causes depression, and also to treat tiredness commonly experienced with depression. | ||
===Serotonin modulators and stimulators (SMSes)=== | |||
===Serotonin antagonists and reuptake inhibitors (SARIs)=== | |||
===Serotonin releasing agents (SRAs)=== | |||
These agents work by directly increasing the amount of serotonin in the brain. Substances such as [[cocaine]] and [[MDMA]] can do this, but both are addictive and tolerance quickly builds to each. Additionally, the MDMA "comedown" can produce weeks to months of a low mood and motivation if the user "rolls" (doses) frequently and suddenly stops. Serotonin releasing agents are not prescribed for depression. | These agents work by directly increasing the amount of serotonin in the brain. Substances such as [[cocaine]] and [[MDMA]] can do this, but both are addictive and tolerance quickly builds to each. Additionally, the MDMA "comedown" can produce weeks to months of a low mood and motivation if the user "rolls" (doses) frequently and suddenly stops. Serotonin releasing agents are not prescribed for depression. | ||
===Norepinephrine reuptake inhibitors (NRIs)=== | ===Norepinephrine reuptake inhibitors (NRIs)=== | ||
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MAOIs are usually prescribed when no other antidepressants are helping. This is because MAOIs require diet changes and have a very large amount of side effects. MAOIs mainly prevent the breakdown of monoamine neurotransmitters in the brain such as [[serotonin]], [[dopamine]], and [[norepinephrine]].<ref>http://www.mayoclinic.org/diseases-conditions/depression/in-depth/maois/art-20043992</ref> | MAOIs are usually prescribed when no other antidepressants are helping. This is because MAOIs require diet changes and have a very large amount of side effects. MAOIs mainly prevent the breakdown of monoamine neurotransmitters in the brain such as [[serotonin]], [[dopamine]], and [[norepinephrine]].<ref>http://www.mayoclinic.org/diseases-conditions/depression/in-depth/maois/art-20043992</ref> | ||
== | ==Experimental treatments== | ||
===[[Psilocybin mushrooms]] (" | ===[[Psilocybin mushrooms]] ("Magic mushrooms")=== | ||
Psilocybin and other classical psychedelics such as [[LSD]] have been researched as a treatment for depression and anxiety, as well as end of life depression and anxiety. Studies have shown that psilocybin is extremely effective in reducing overall depression and anxiety. | Psilocybin and other classical psychedelics such as [[LSD]] have been researched as a treatment for depression and anxiety, as well as end of life depression and anxiety. Studies have shown that psilocybin is extremely effective in reducing overall depression and anxiety. | ||
===[[Ketamine]]=== | ===[[Ketamine]]=== | ||