Mirtazapine: Difference between revisions

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'''Mirtazapine''' (trade names '''Remeron''', '''Avanza''', '''Zispin''' and many others) is a [[Chemical class::tetracyclic|tetracyclic antidepressant]] that, at higher doses, produces atypical [[Psychoactive class::psychedelic]], [[Psychoactive class::deliriant]], and [[sedative]] effects when [[administered]].

Mirtazapine was developed ~~by Organon International~~ in the Netherlands and ~~was~~ introduced in the United States in 1996.<ref> "REMERON (mirtazapine) tablet, film coated [Organon Pharmaceuticals USA]". DailyMed. Organon Pharmaceuticals USA. October 2012. Retrieved 24 October 2013.</ref> Its patent expired in 2004 and generic versions have been widely available since.<ref>Schatzberg, AF; Cole, JO; DeBattista, C. "3". Manual of Clinical Psychopharmacology (7th ed.). Arlington, VA: American Psychiatric Publishing.</ref>

Mirtazapine was developed in the Netherlands and introduced in the United States in 1996.<ref> "REMERON (mirtazapine) tablet, film coated [Organon Pharmaceuticals USA]". DailyMed. Organon Pharmaceuticals USA. October 2012. Retrieved 24 October 2013.</ref> Its patent expired in 2004 and generic versions have been widely available since.<ref>Schatzberg, AF; Cole, JO; DeBattista, C. "3". Manual of Clinical Psychopharmacology (7th ed.). Arlington, VA: American Psychiatric Publishing.</ref>

Mirtazapine is broadly classified as a [[adrenergic]] and [[serotonergic]] [[antagonist]], and also has strong effects as an [[antihistamine]].<ref>Schatzberg, AF; Cole, JO; DeBattista, C. "3". Manual of Clinical Psychopharmacology (7th ed.). Arlington, VA: American Psychiatric Publishing.</ref>

Mirtazapine is broadly classified as an [[adrenergic]] and [[serotonergic]] [[antagonist]], and also has strong effects as an [[antihistamine]].<ref>Schatzberg, AF; Cole, JO; DeBattista, C. "3". Manual of Clinical Psychopharmacology (7th ed.). Arlington, VA: American Psychiatric Publishing.</ref>

Mirtazapine is used primarily in the treatment of major depressive disorder and other mood disorders.<ref>Mirtazapine: clinical overview. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/10446735</ref><ref>Review of the use of mirtazapine in the treatment of depression | http://informahealthcare.com/doi/abs/10.1517/14656566.2011.585459</ref> However, it has also been found useful in alleviating the following conditions and may be prescribed off-label for the treatment of

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 '''Mirtazapine''' (trade names '''Remeron''', '''Avanza''', '''Zispin''' and many others) is a [[Chemical class::tetracyclic|tetracyclic antidepressant]] that, at higher doses, produces atypical [[Psychoactive class::psychedelic]], [[Psychoactive class::deliriant]], and [[sedative]] effects when [[administered]].
-Mirtazapine was developed by Organon International in the Netherlands and was introduced in the United States in 1996.<ref> "REMERON (mirtazapine) tablet, film coated [Organon Pharmaceuticals USA]". DailyMed. Organon Pharmaceuticals USA. October 2012. Retrieved 24 October 2013.</ref> Its patent expired in 2004 and generic versions have been widely available since.<ref>Schatzberg, AF; Cole, JO; DeBattista, C. "3". Manual of Clinical Psychopharmacology (7th ed.). Arlington, VA: American Psychiatric Publishing.</ref>
+Mirtazapine was developed in the Netherlands and introduced in the United States in 1996.<ref> "REMERON (mirtazapine) tablet, film coated [Organon Pharmaceuticals USA]". DailyMed. Organon Pharmaceuticals USA. October 2012. Retrieved 24 October 2013.</ref> Its patent expired in 2004 and generic versions have been widely available since.<ref>Schatzberg, AF; Cole, JO; DeBattista, C. "3". Manual of Clinical Psychopharmacology (7th ed.). Arlington, VA: American Psychiatric Publishing.</ref>
-Mirtazapine is broadly classified as a [[adrenergic]] and [[serotonergic]] [[antagonist]], and also has strong effects as an [[antihistamine]].<ref>Schatzberg, AF; Cole, JO; DeBattista, C. "3". Manual of Clinical Psychopharmacology (7th ed.). Arlington, VA: American Psychiatric Publishing.</ref>
+Mirtazapine is broadly classified as an [[adrenergic]] and [[serotonergic]] [[antagonist]], and also has strong effects as an [[antihistamine]].<ref>Schatzberg, AF; Cole, JO; DeBattista, C. "3". Manual of Clinical Psychopharmacology (7th ed.). Arlington, VA: American Psychiatric Publishing.</ref>
 Mirtazapine is used primarily in the treatment of major depressive disorder and other mood disorders.<ref>Mirtazapine: clinical overview. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/10446735</ref><ref>Review of the use of mirtazapine in the treatment of depression | http://informahealthcare.com/doi/abs/10.1517/14656566.2011.585459</ref> However, it has also been found useful in alleviating the following conditions and may be prescribed off-label for the treatment of