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Modafinil: Difference between revisions
>Kenan m Rephrase, use sensible citations |
>Kenan m Substance-specific, non-class-specific interactions should be at the bottom |
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{{DangerousInteractions/Intro}} | {{DangerousInteractions/Intro}} | ||
{{DangerousInteractions/Stimulants|self=modafinil}} | {{DangerousInteractions/Stimulants|self=modafinil}} | ||
{{DangerousInteractions/MAOI|nt=dopamine}} | |||
*'''[[DangerousInteraction::MDMA]]''' - The neurotoxic effects of [[MDMA]] may be increased when combined with other stimulants. | *'''[[DangerousInteraction::MDMA]]''' - The neurotoxic effects of [[MDMA]] may be increased when combined with other stimulants. | ||
*'''[[DangerousInteraction::Hormonal Birth Control]]''' - Modafinil reduces the effectiveness of hormonal birth control for up to a month after use by increasing the activity of the enzyme CYP3A4/5.<ref>{{cite journal | last=Robertson | first=P | title=Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers | journal=Clinical Pharmacology & Therapeutics | publisher=Springer Nature | volume=71 | issue=1 | year=2002 | issn=0009-9236 | doi=10.1067/mcp.2002.121217 | pages=46–56}}</ref> Notably, the same enzyme is inhibited by grapefruit juice.<ref>{{cite journal | last=Bailey | first=D. G. | last2=Dresser | first2=G. | last3=Arnold | first3=J. M. O. | title=Grapefruit-medication interactions: Forbidden fruit or avoidable consequences? | journal=Canadian Medical Association Journal | publisher=Joule Inc. | volume=185 | issue=4 | date=2012-11-26 | issn=0820-3946 | doi=10.1503/cmaj.120951 | pages=309–316}}</ref> | *'''[[DangerousInteraction::Hormonal Birth Control]]''' - Modafinil reduces the effectiveness of hormonal birth control for up to a month after use by increasing the activity of the enzyme CYP3A4/5.<ref>{{cite journal | last=Robertson | first=P | title=Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers | journal=Clinical Pharmacology & Therapeutics | publisher=Springer Nature | volume=71 | issue=1 | year=2002 | issn=0009-9236 | doi=10.1067/mcp.2002.121217 | pages=46–56}}</ref> Notably, the same enzyme is inhibited by grapefruit juice.<ref>{{cite journal | last=Bailey | first=D. G. | last2=Dresser | first2=G. | last3=Arnold | first3=J. M. O. | title=Grapefruit-medication interactions: Forbidden fruit or avoidable consequences? | journal=Canadian Medical Association Journal | publisher=Joule Inc. | volume=185 | issue=4 | date=2012-11-26 | issn=0820-3946 | doi=10.1503/cmaj.120951 | pages=309–316}}</ref> | ||
==Legality== | ==Legality== | ||