GHB: Difference between revisions

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===Dangerous interactions===

Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. [https://~~www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.~~

*'''[[Depressants]]''' (''[[1,4-Butanediol]], [[2-methyl-2-butanol]], [[alcohol]], [[barbiturates]], [[benzodiazepines]], [[GBL]], [[methaqualone]], [[opioids]], [[gabapentin]], [[pregabalin]], [[phenibut]]'') - This combination can result in dangerous or even fatal levels of [[respiratory depression]]. A review of the details of 194 deaths attributed to or related to GHB over a ten-year period found that most were from respiratory depression caused by interaction with alcohol or other drugs.<ref>http:/~~/web.archive.org/web/20071203005230/http://www.aafs.org/pdf/Seattleabstracts06.pdf</ref> In humans,~~ GHB has been shown to inhibit the elimination rate of alcohol. This may explain the respiratory arrest that has been reported after ingestion of both drugs.<ref>The role of gamma-hydroxybutyric acid in the treatment of alcoholism: from animal to clinical studies (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/10075397</ref> These substances potentiate the [[muscle relaxation]], [[sedation]] and [[amnesia]] caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation.<ref>https://www.erowid.org/chemicals/ghb/ghb_health.shtml</ref><ref>Suspicious death related to gamma-hydroxybutyrate (GHB) toxicity (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/15274975</ref> If this occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.

*'''[[Dissociatives]]''' - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.

*'''[[Stimulants]]''' - It is dangerous to combine GHB, a [[depressant]], with [[stimulant]]s due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of GHB, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of GHB will be significantly increased, leading to intensified [[disinhibition]] as well as [[GHB#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only dosing a certain amount of GHB per hour. This combination can also potentially result in severe dehydration if hydration is not monitored.

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 ===Dangerous interactions===
-Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
+{{DangerousInteractions/Intro}}
-*'''[[Depressants]]''' (''[[1,4-Butanediol]], [[2-methyl-2-butanol]], [[alcohol]], [[barbiturates]], [[benzodiazepines]], [[GBL]], [[methaqualone]], [[opioids]], [[gabapentin]], [[pregabalin]], [[phenibut]]'') - This combination can result in dangerous or even fatal levels of [[respiratory depression]]. A review of the details of 194 deaths attributed to or related to GHB over a ten-year period found that most were from respiratory depression caused by interaction with alcohol or other drugs.<ref>http://web.archive.org/web/20071203005230/http://www.aafs.org/pdf/Seattleabstracts06.pdf</ref> In humans, GHB has been shown to inhibit the elimination rate of alcohol. This may explain the respiratory arrest that has been reported after ingestion of both drugs.<ref>The role of gamma-hydroxybutyric acid in the treatment of alcoholism: from animal to clinical studies (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/10075397</ref> These substances potentiate the [[muscle relaxation]], [[sedation]] and [[amnesia]] caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation.<ref>https://www.erowid.org/chemicals/ghb/ghb_health.shtml</ref><ref>Suspicious death related to gamma-hydroxybutyrate (GHB) toxicity (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/15274975</ref> If this occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.
+{{DangerousInteractions/Depressants}}
-*'''[[Dissociatives]]''' - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.
+{{DangerousInteractions/GHB}}
+{{DangerousInteractions/Dissociatives}}
 *'''[[Stimulants]]''' -  It is dangerous to combine GHB, a [[depressant]], with [[stimulant]]s due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of GHB, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of GHB will be significantly increased, leading to intensified [[disinhibition]] as well as [[GHB#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only dosing a certain amount of GHB per hour. This combination can also potentially result in severe dehydration if hydration is not monitored.