3-HO-PCE: Difference between revisions

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While no formal studies have been conducted, 3-HO-PCE likely acts principally as an [[NMDA receptor antagonist]].<ref name="3HOPCEsar" />

~~A specific subtype of [[glutamate]] receptor, the~~ NMDA (N-Methyl-D-Aspartate) receptor modulates the transmission of electrical signals between neurons in the brain and spinal cord; for the signals to pass, the receptor must be open. Dissociatives inhibit the normal functioning NMDA receptors by binding to and blocking them. This disruption of neural network activity leads to loss of normal cognitive and affective processing, psychomotor functioning, anesthesia.{{citation needed}}

The NMDA (N-Methyl-D-Aspartate) receptor, specific subtype of [[glutamate]] receptor, modulates the transmission of electrical signals between neurons in the brain and spinal cord; for the signals to pass, the receptor must be open.

Dissociatives inhibit the normal functioning NMDA receptors by binding to and blocking them. This disruption of neural network activity leads to loss of normal cognitive and affective processing, psychomotor functioning, anesthesia.{{citation needed}}

There is ongoing speculation as to whether this compound displays [[μ-opioid]] receptor activity due to its structural relationship to 3-HO-PCP, which has been found to have appreciable affinity as a [[μ-opioid]] [[receptor]] [[agonist]] in animal models.<ref name="3HOPCEsar" />

@@ Line 19: / Line 19: @@
 While no formal studies have been conducted, 3-HO-PCE likely acts principally as an [[NMDA receptor antagonist]].<ref name="3HOPCEsar" />
-A specific subtype of [[glutamate]] receptor, the NMDA (N-Methyl-D-Aspartate) receptor modulates the transmission of electrical signals between neurons in the brain and spinal cord; for the signals to pass, the receptor must be open. Dissociatives inhibit the normal functioning NMDA receptors by binding to and blocking them. This disruption of neural network activity leads to loss of normal cognitive and affective processing, psychomotor functioning, anesthesia.{{citation needed}}
+The NMDA (N-Methyl-D-Aspartate) receptor, specific subtype of [[glutamate]] receptor,  modulates the transmission of electrical signals between neurons in the brain and spinal cord; for the signals to pass, the receptor must be open.
+Dissociatives inhibit the normal functioning NMDA receptors by binding to and blocking them. This disruption of neural network activity leads to loss of normal cognitive and affective processing, psychomotor functioning, anesthesia.{{citation needed}}
 There is ongoing speculation as to whether this compound displays [[μ-opioid]] receptor activity due to its structural relationship to 3-HO-PCP, which has been found to have appreciable affinity as a [[μ-opioid]] [[receptor]] [[agonist]] in animal models.<ref name="3HOPCEsar" />