25I-NBOMe: Difference between revisions

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It is worth noting that compounds of the [[25x-NBOMe|NBOMe]] family are not [[orally]] active and should be administered [[sublingual|sublingually]] by placing and holding it into one's mouth and allowing it to absorb over a period of 15-25 minutes. 25I-NBOMe can also be vaporized and inhaled; this is known to cause significantly more rapid and powerful effects and a shorter duration. However, this route of administration is heavily advised against due to the difficulties of measuring and handling substances that both have a low [[therapeutic index]] and are also active in the microgram range.

In comparison to [[2C-I]], the addition of an NBOMe group to the structure results in a sixteen-fold increase in potency, allowing even the heaviest of dosages to fit in liquid form onto tabs and blotter paper, which are often misrepresented or mistaken for [[LSD]]. In contrast to LSD, 25i-NBOMe has a distinctly bitter and metallic taste that numbs the location of the mouth it is applied to. This property is often used as a makeshift test for its authenticity but is generally advised against. Users instead are encouraged to test all of their blotters through a drug testing service or with the appropriate reagent testing kit due to the hazards this substance can pose.

This substance had no history of human use before being sold online as a [[designer drug]] in 2010.{{citation needed}} Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25I-NBOMe in humans, and it has been associated with many deaths and hospitalizations. Along with its highly sensitive dose-response and unpredictable effects, many reports also suggest that this substance may be overly difficult to use safely. Therefore it is highly advised to approach this poorly understood [[psychedelic]] substance with the proper amount of precaution and [[Responsible drug use#Hallucinogens|harm reduction practices]] if choosing to use it.

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A Brazilian 16-year-old died from overdose in April 2016.{{citation needed}}

The addition of ~~5HTP~~ can greatly increase the effects of 25i-NBOME and should be avoided.{{citation needed}}

The addition of 5-HTP can greatly increase the effects of 25i-NBOME and should be avoided.{{citation needed}}

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.

~~It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.~~

===Tolerance and addiction potential===

25I-NBOMe is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 25I-NBOMe are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::1 week]] for the tolerance to be reduced to half and [[Time to zero tolerance::2 weeks]] to be back at baseline (in the absence of further consumption). 25I-NBOMe presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 25I-NBOMe all psychedelics will have a reduced effect.

===Common misrepresentation as LSD===

In comparison to [[2C-I]], the addition of an NBOMe group to the structure results in a sixteen-fold increase in potency. This allows for even the heaviest of dosages to fit in liquid form onto tabs and blotter paper, which are often misrepresented or mistaken for [[LSD]]. In contrast to LSD, 25i-NBOMe has a distinctly bitter and metallic taste that selectively numbs the part of the mouth it is applied to. This property is often used as a makeshift test for its authenticity but is generally advised against. Users instead are encouraged to test all of their blotters through a drug testing service or with the appropriate reagent testing kit (such as the Ehrlich's reagent) due to the unique toxicity risks this substance can pose, especially if taken in the same manner or assumed doses as LSD.

===Dangerous interactions===

@@ Line 7: / Line 7: @@
 It is worth noting that compounds of the [[25x-NBOMe|NBOMe]] family are not [[orally]] active and should be administered [[sublingual|sublingually]] by placing and holding it into one's mouth and allowing it to absorb over a period of 15-25 minutes. 25I-NBOMe can also be vaporized and inhaled; this is known to cause significantly more rapid and powerful effects and a shorter duration. However, this route of administration is heavily advised against due to the difficulties of measuring and handling substances that both have a low [[therapeutic index]] and are also active in the microgram range.
-In comparison to [[2C-I]], the addition of an NBOMe group to the structure results in a sixteen-fold increase in potency, allowing even the heaviest of dosages to fit in liquid form onto tabs and blotter paper, which are often misrepresented or mistaken for [[LSD]]. In contrast to LSD, 25i-NBOMe has a distinctly bitter and metallic taste that numbs the location of the mouth it is applied to. This property is often used as a makeshift test for its authenticity but is generally advised against. Users instead are encouraged to test all of their blotters through a drug testing service or with the appropriate reagent testing kit due to the hazards this substance can pose.
 This substance had no history of human use before being sold online as a [[designer drug]] in 2010.{{citation needed}} Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25I-NBOMe in humans, and it has been associated with many deaths and hospitalizations. Along with its highly sensitive dose-response and unpredictable effects, many reports also suggest that this substance may be overly difficult to use safely. Therefore it is highly advised to approach this poorly understood [[psychedelic]] substance with the proper amount of precaution and [[Responsible drug use#Hallucinogens|harm reduction practices]] if choosing to use it.
@@ Line 190: / Line 188: @@
 A Brazilian 16-year-old died from overdose in April 2016.{{citation needed}}
-The addition of 5HTP can greatly increase the effects of 25i-NBOME and should be avoided.{{citation needed}}
+The addition of 5-HTP can greatly increase the effects of 25i-NBOME and should be avoided.{{citation needed}}
+It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
-It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
 ===Tolerance and addiction potential===
 I-NBOMe is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.
 Tolerance to the effects of 25I-NBOMe are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::1 week]] for the tolerance to be reduced to half and [[Time to zero tolerance::2 weeks]] to be back at baseline (in the absence of further consumption). 25I-NBOMe presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 25I-NBOMe all psychedelics will have a reduced effect.
+===Common misrepresentation as LSD===
+In comparison to [[2C-I]], the addition of an NBOMe group to the structure results in a sixteen-fold increase in potency. This allows for even the heaviest of dosages to fit in liquid form onto tabs and blotter paper, which are often misrepresented or mistaken for [[LSD]]. In contrast to LSD, 25i-NBOMe has a distinctly bitter and metallic taste that selectively numbs the part of the mouth it is applied to. This property is often used as a makeshift test for its authenticity but is generally advised against. Users instead are encouraged to test all of their blotters through a drug testing service or with the appropriate reagent testing kit (such as the Ehrlich's reagent) due to the unique toxicity risks this substance can pose, especially if taken in the same manner or assumed doses as LSD.
 ===Dangerous interactions===