Proscaline: Difference between revisions

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'''Proscaline''' (also known as '''4-propyloxy-3,5-dimethoxyphenethylamine''') is a [[Psychoactive class::psychedelic]] of the [[Chemical class::phenethylamine]] class.<ref>Alexander Shulgin - PIHKAL | http://www.erowid.org/library/books_online/pihkal/pihkal140.shtml</ref> It has structural and pharmacological properties similar to its parent drug [[mescaline]] as well as to its analogs such as [[isoproscaline]], [[escaline]] and [[allylescaline]].

The synthesis of proscaline was first published by David E. Nichols in 1977<ref>"Lipophilicity and serotonin agonist activity in a series of 4-substituted mescaline analogues." Nichols DE, Dyer DC. J Med Chem. 1977 Feb;20(2):299-301.</ref> Around the same time, [[Alexander Shulgin]] sampled and evaluated the chemical at doses up to 60mg, estimating its potency as five times that of [[mescaline]].<ref>Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p209 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf</ref> Shulgin later documented Proscaline in his 1991 book "[[PiHKAL]]: A Chemical Love Story". In modern times it is primarily used as a recreational drug, rarely if ever sold on the streets and almost exclusively obtained as a grey area [[research chemical]] through the use of online vendors. It is relatively obscure and has only a short history of human use.

The synthesis of proscaline was first published by David E. Nichols in 1977.<ref>"Lipophilicity and serotonin agonist activity in a series of 4-substituted mescaline analogues." Nichols DE, Dyer DC. J Med Chem. 1977 Feb;20(2):299-301.</ref> Around the same time, [[Alexander Shulgin]] sampled and evaluated the chemical at doses up to 60mg, estimating its potency as five times that of [[mescaline]].<ref>Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p209 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf</ref> Shulgin later documented Proscaline in his 1991 book "[[PiHKAL]]: A Chemical Love Story". In modern times it is primarily used as a recreational drug, rarely if ever sold on the streets and almost exclusively obtained as a grey area [[research chemical]] through the use of online vendors. It is relatively obscure and has only a short history of human use.

==Chemistry==

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 '''Proscaline''' (also known as '''4-propyloxy-3,5-dimethoxyphenethylamine''') is a [[Psychoactive class::psychedelic]] of the [[Chemical class::phenethylamine]] class.<ref>Alexander Shulgin - PIHKAL | http://www.erowid.org/library/books_online/pihkal/pihkal140.shtml</ref> It has structural and pharmacological properties similar to its parent drug [[mescaline]] as well as to its analogs such as [[isoproscaline]], [[escaline]] and [[allylescaline]].
-The synthesis of proscaline was first published by David E. Nichols in 1977<ref>"Lipophilicity and serotonin agonist activity in a series of 4-substituted mescaline analogues." Nichols DE, Dyer DC. J Med Chem. 1977 Feb;20(2):299-301.</ref> Around the same time, [[Alexander Shulgin]] sampled and evaluated the chemical at doses up to 60mg, estimating its potency as five times that of [[mescaline]].<ref>Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p209 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf</ref> Shulgin later documented Proscaline in his 1991 book "[[PiHKAL]]: A Chemical Love Story". In modern times it is primarily used as a recreational drug, rarely if ever sold on the streets and almost exclusively obtained as a grey area [[research chemical]] through the use of online vendors. It is relatively obscure and has only a short history of human use.
+The synthesis of proscaline was first published by David E. Nichols in 1977.<ref>"Lipophilicity and serotonin agonist activity in a series of 4-substituted mescaline analogues." Nichols DE, Dyer DC. J Med Chem. 1977 Feb;20(2):299-301.</ref> Around the same time, [[Alexander Shulgin]] sampled and evaluated the chemical at doses up to 60mg, estimating its potency as five times that of [[mescaline]].<ref>Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p209 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf</ref> Shulgin later documented Proscaline in his 1991 book "[[PiHKAL]]: A Chemical Love Story". In modern times it is primarily used as a recreational drug, rarely if ever sold on the streets and almost exclusively obtained as a grey area [[research chemical]] through the use of online vendors. It is relatively obscure and has only a short history of human use.
 ==Chemistry==