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MDEA: Difference between revisions
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'''3,4-Methylenedioxy-N-ethylamphetamine''' (also known as, '''Methylenedioxyethylamphetamine''', '''MDEA''', '''MDE''', and colloquially as '''Eve''') is an obscure, synthetic [[Psychoactive class::entactogen]] of the [[Chemical class::amphetamines|substituted amphetamine]] class that produces modified [[MDMA|MDMA-like]] entactogenic effects when [[routes of administration|administered]]. It is a closely related structural analog of [[MDMA]] and [[MDA]]<ref>PiHKAL|http://isomerdesign.com/PiHKAL/read.php?domain=pk&id=106</ref> that | '''3,4-Methylenedioxy-N-ethylamphetamine''' (also known as, '''Methylenedioxyethylamphetamine''', '''MDEA''', '''MDE''', and colloquially as '''Eve''') is an obscure, synthetic [[Psychoactive class::entactogen]] of the [[Chemical class::amphetamines|substituted amphetamine]] class that produces modified [[MDMA|MDMA-like]] entactogenic effects when [[routes of administration|administered]]. It is a closely related structural analog of [[MDMA]] and [[MDA]]<ref>PiHKAL|http://isomerdesign.com/PiHKAL/read.php?domain=pk&id=106</ref> that acts via the same pharmacological mechanism as a [[serotonin]], [[norepinephrine]], and [[dopamine]] [[releasing agent]] and [[reuptake inhibitor]].<ref name="MDEApharm">Freudenmann RW, Spitzer M (2004). "The Neuropsychopharmacology and Toxicology of 3,4-methylenedioxy-N-ethyl-amphetamine (MDEA)". CNS Drug Reviews. 10 (2): 89–116. https://doi.org10.1111/j.1527-3458.2004.tb00007.x. PMID 15179441.</ref> | ||
In a 1967 lab notebook entry, [[Alexander Shulgin]] briefly mentions a colleague's report of no effect from the substance with a 100mg dose.<ref>Rediscovering MDMA (ecstasy): the role of the American chemist Alexander T. Shulgin|doi=10.1111/j.1360-0443.2010.02948.x}}</ref> Shulgin later tested the compound at a range of higher doses and characterized the substance in his book "[[PiHKAL]]" ("[[Phenethylamine]]s I Have Known and Loved").<ref>PiHKAL|http://isomerdesign.com/PiHKAL/read.php?domain=pk&id=106</ref> | In a 1967 lab notebook entry, [[Alexander Shulgin]] briefly mentions a colleague's report of no effect from the substance with a 100mg dose.<ref>Rediscovering MDMA (ecstasy): the role of the American chemist Alexander T. Shulgin|doi=10.1111/j.1360-0443.2010.02948.x}}</ref> Shulgin later tested the compound at a range of higher doses and characterized the substance in his book "[[PiHKAL]]" ("[[Phenethylamine]]s I Have Known and Loved").<ref>PiHKAL|http://isomerdesign.com/PiHKAL/read.php?domain=pk&id=106</ref> | ||