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'''5-(2-Aminopropyl)benzofuran''' (commonly known as '''5-APB''') is a novel synthetic [[Psychoactive class::entactogen]] of the substituted [[chemical class::benzofuran]] and [[chemical class::amphetamine]] chemical classes that produces [[MDA]]-like [[euphoria|euphoric]], [[entactogenic]], [[stimulant|stimulating]] and mild [[hallucinogenic]] effects when [[Routes of administration|administered]].
'''5-(2-Aminopropyl)benzofuran''' (commonly known as '''5-APB''') is a novel synthetic [[Psychoactive class::entactogen]] of the substituted [[chemical class::benzofuran]] and [[chemical class::amphetamine]] chemical classes that produces [[MDA]]-like [[euphoria|euphoric]], [[entactogenic]], [[stimulant|stimulating]] and mild [[hallucinogenic]] effects when [[Routes of administration|administered]].


Compared to other members of its family such as [[6-APB]] and [[5-MAPB]], this compound in particular is known for its [[stimulating]] and [[euphoria|euphoric]] effects which has resulted in its rise in popularity as a product which is easily accessible through the use of certain online [[research chemical]] vendors. It has been sold as a [[designer drug]] since 2010.<ref>EMCDDA–Europol 2010 Annual Report on the implementation of Council Decision 2005/387/JHA | http://www.emcdda.europa.eu/publications/implementation-reports/2010</ref>
Compared to other members of its family such as [[6-APB]] and [[5-MAPB]], this compound in particular is known for its [[stimulating]] and [[euphoria|euphoric]] effects which has resulted in its rise in popularity as a product which is easily accessible through the use of online [[research chemical]] vendors. It has been commercially distributed as a [[designer drug]] alternative to [[MDMA]] since 2010.<ref>EMCDDA–Europol 2010 Annual Report on the implementation of Council Decision 2005/387/JHA | http://www.emcdda.europa.eu/publications/implementation-reports/2010</ref>
 
Very little data exists about the pharmacological properties, metabolism, and toxicity of 5-APB in humans, and it has only a brief history of human usage. Due to its potent entactogenic and stimulant effects, and dependence and addiction-producing potential if misused, it is highly advised that one take proper precautions, conduct [https://www.google.com independent research], and use proper [[harm reduction practices]] if choosing to use with this substance.


5-APB is commonly found as the succinate and hydrochloride salt. The hydrochloride salt is 10% more potent by mass so doses should be adjusted accordingly.
==Chemistry==
==Chemistry==
5-(2-aminopropyl)benzofuran, also known as 5-APB, is a [[benzofuran]] and [[phenethylamine]], meaning it has an ethylamine chain and a furan ring attached to the core benzene ring. It can also be classified as an amphetamine derivative because the ethylamine chain is alpha methylated. Molecules of the amphetamine class contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at R<sub>α</sub>. The oxygen in the furan ring is placed at the 5 position, which generally constitutes more stimulating effects than when the oxygen is placed at the 6 position, which is usually described as being more [[psychedelic]] in effects.
5-(2-aminopropyl)benzofuran, also known as 5-APB, is a [[benzofuran]] and [[phenethylamine]], meaning it has an ethylamine chain and a furan ring attached to the core benzene ring. It can also be classified as an amphetamine derivative because the ethylamine chain is alpha methylated. Molecules of the amphetamine class contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at R<sub>α</sub>. The oxygen in the furan ring is placed at the 5 position, which generally constitutes more stimulating effects than when the oxygen is placed at the 6 position, which is usually described as being more [[psychedelic]] in effects.
===Forms===
5-APB is commonly found as the succinate and hydrochloride salt.{{citation needed}} The hydrochloride salt is 10% more potent by mass so doses should be adjusted accordingly.


==Pharmacology==
==Pharmacology==
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===Physical effects===
===Physical effects===
*'''[[Effect::Stimulation]]'''
*'''[[Effect::Stimulation]]'''
*'''[[Effect::Abnormal heartbeat]]'''
*'''[[Effect::Increased heart rate]]'''
*'''[[Effect::Increased heart rate]]'''
*'''[[Effect::Muscle contractions]]'''
*'''[[Effect::Increased perspiration]]'''
*'''[[Effect::Dehydration]]'''
*'''[[Effect::Dehydration]]'''
*'''[[Effect::Appetite suppression]]'''
*'''[[Effect::Appetite suppression]]'''
*'''[[Effect::Nausea]]'''  
*'''[[Effect::Nausea]]'''  
*'''[[Effect::Temporary erectile dysfunction]]'''
*'''[[Effect::Temporary erectile dysfunction]]'''
*'''[[Effect::Increased perspiration]]'''


===Cognitive effects===
===Cognitive effects===
*'''[[Effect::Empathy, love, and sociability enhancement]]'''
*'''[[Effect::Empathy, affection, and sociability enhancement]]'''
*'''[[Effect::Cognitive euphoria]]'''
*'''[[Effect::Compulsive redosing]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Focus enhancement]]'''  
*'''[[Effect::Focus enhancement]]'''  
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Wakefulness]]'''
*'''[[Effect::Memory enhancement]]'''
*'''[[Effect::Memory enhancement]]'''
*'''[[Effect::Motivation enhancement]]'''
*'''[[Effect::Motivation enhancement]]'''
*'''[[Effect::Cognitive euphoria|Euphoria]]'''
*'''[[Effect::Wakefulness]]'''
*'''[[Effect::Compulsive redosing]]'''
*'''[[Effect::Increased music appreciation]]'''


===Visual effects===
===Visual effects===
*'''[[Effect::Acuity enhancement]]'''
*'''[[Effect::Acuity enhancement]]'''
===After effects===
===After effects===
The effects which occur during the [[offset]] of a [[stimulant]] experience generally feel negative and uncomfortable in comparison to the effects which occurred during its [[peak]]. This is often referred to as a "comedown" and occurs because of [[neurotransmitter]] depletion. Its effects commonly include:
The effects which occur during the [[offset]] of a [[stimulant]] experience generally feel negative and uncomfortable in comparison to the effects which occurred during its [[peak]]. This is often referred to as a "comedown" and occurs because of [[neurotransmitter]] depletion. Its effects commonly include:
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