4F-MPH: Difference between revisions

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'''4-Fluoromethylphenidate''' (commonly known as '''4F-MPH''') is a novel synthetic [[psychoactive class::stimulant]] of the [[chemical class::substituted phenethylamine]] and [[chemical class::piperidine]] classes that produces long-lasting [[Euphoria|euphoriant]], and [[stimulant|stimulating]] effects associated with [[monoamine]] [[reuptake inhibitor]]s when [[Routes of administration|adminstered]]. It is a closely related structural analog of the commonly prescribed ADHD drug [[methylphenidate]] (known by the brand-names ''Ritalin'' and ''Focalin'').

The two substances are believed to have very similar pharmacological mechanisms but have been reported to display distinctive [[subjective effects index|subjective effects]], with 4F-MPH being considered significantly more euphoric and recreational. Anecdotal reports suggest that it is considerably more potent with fewer uncomfortable side effects such as [[anxiety]], [[muscle spasms]] and [[compulsive redosing]].<ref>http://www.bluelight.org/vb/threads/770658-4-Fluoromethylphenidate-(4F-MPH)</ref> This perhaps owes to the fact that it has been shown to act as a higher efficiency [[dopamine]] reuptake inhibitor than the parent compound methylphenidate.<ref>Deutsch, H. M., Shi, Q., Gruszecka-Kowalik, E., & Schweri, M. M. (1996). Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs. Journal of medicinal chemistry, 39(6), 1201-1209. https://www.doi.org/10.1021/jm950697c</ref><ref>Biochemical and behavioral characterization of novel methylphenidate analogs (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/11961053</ref><ref>Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/15026075</ref><ref>Quantitative structure-activity relationship studies of threo-methylphenidate analogs (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/20846865</ref><ref>Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists | http://pubs.acs.org/doi/abs/10.1021/cr9700538</ref>

4F-MPH has an extremely short history of [[recreational drug use|recreational use]] and has yet to be documented being sold on the streets. It was initially developed as a replacement for [[ethylphenidate]] which became illegal in the United Kingdom on April 2015 following a temporary blanket ban ~~that later became permanent~~. Shortly after, it recently became made available for sale on the online gray market as a [[research chemical]] for global distribution.

4F-MPH has an extremely short history of [[recreational drug use|recreational use]] and has yet to be documented being sold on the streets. It was initially developed as a replacement for [[ethylphenidate]] which became illegal in the United Kingdom on April 2015 following a temporary blanket ban. Shortly after, it recently became made available for sale on the online gray market as a [[research chemical]] for global distribution.

Due to its potent, long-lasting stimulant effect, likely habit-forming properties as well as unknown toxicity profile, it is strongly recommended that one use proper [[harm reduction]] practices if choosing to use this substance.

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 {{headerpanel|{{approval}}}}
 {{SubstanceBox/4F-MPH}}
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-| ''[[4F-MPH/Summary|Summary sheet: 4F-MPH]]''
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 '''4-Fluoromethylphenidate''' (commonly known as '''4F-MPH''') is a novel synthetic [[psychoactive class::stimulant]] of the [[chemical class::substituted phenethylamine]] and [[chemical class::piperidine]] classes that produces long-lasting [[Euphoria|euphoriant]], and [[stimulant|stimulating]] effects associated with [[monoamine]] [[reuptake inhibitor]]s when [[Routes of administration|adminstered]]. It is a closely related structural analog of the commonly prescribed ADHD drug [[methylphenidate]] (known by the brand-names ''Ritalin'' and ''Focalin'').
 The two substances are believed to have very similar pharmacological mechanisms but have been reported to display distinctive [[subjective effects index|subjective effects]], with 4F-MPH being considered significantly more euphoric and recreational. Anecdotal reports suggest that it is considerably more potent with fewer uncomfortable side effects such as [[anxiety]], [[muscle spasms]] and [[compulsive redosing]].<ref>http://www.bluelight.org/vb/threads/770658-4-Fluoromethylphenidate-(4F-MPH)</ref> This perhaps owes to the fact that it has been shown to act as a higher efficiency [[dopamine]] reuptake inhibitor than the parent compound methylphenidate.<ref>Deutsch, H. M., Shi, Q., Gruszecka-Kowalik, E., & Schweri, M. M. (1996). Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs. Journal of medicinal chemistry, 39(6), 1201-1209. https://www.doi.org/10.1021/jm950697c</ref><ref>Biochemical and behavioral characterization of novel methylphenidate analogs (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/11961053</ref><ref>Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/15026075</ref><ref>Quantitative structure-activity relationship studies of threo-methylphenidate analogs (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/20846865</ref><ref>Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists | http://pubs.acs.org/doi/abs/10.1021/cr9700538</ref>
-F-MPH has an extremely short history of [[recreational drug use|recreational use]] and has yet to be documented being sold on the streets. It was initially developed as a replacement for [[ethylphenidate]] which became illegal in the United Kingdom on April 2015 following a temporary blanket ban that later became permanent. Shortly after, it recently became made available for sale on the online gray market as a [[research chemical]] for global distribution.
+F-MPH has an extremely short history of [[recreational drug use|recreational use]] and has yet to be documented being sold on the streets. It was initially developed as a replacement for [[ethylphenidate]] which became illegal in the United Kingdom on April 2015 following a temporary blanket ban. Shortly after, it recently became made available for sale on the online gray market as a [[research chemical]] for global distribution.
 Due to its potent, long-lasting stimulant effect, likely habit-forming properties as well as unknown toxicity profile, it is strongly recommended that one use proper [[harm reduction]] practices if choosing to use this substance.