MDMA/Synthesis: Difference between revisions

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=== Synthesis ===

* From safrole (with aqueous HBr) to 5-(2-bromopropyl)benzo-1,3-dioxole; (with methyl amine in EtOH) to ~~MOMA~~ (Merck, 1912; Bineicki and Krajewski, 1960).

* From safrole (with aqueous HBr) to 5-(2-bromopropyl)benzo-1,3-dioxole; (with methyl amine in EtOH) to MDMA (Merck, 1912; Bineicki and Krajewski, 1960).

* From 3,4-methylenedioxyphenylacetone (aka: piperonylacetone; with methylamine, sodium cyanoborohydride) to ~~MOMA~~ (Braun et al., 1980).

* From 3,4-methylenedioxyphenylacetone (aka: piperonylacetone; with methylamine, sodium cyanoborohydride) to MDMA (Braun et al., 1980).

* From ~~MOA~~ (with formic acid or ethyl formate) to ''N''-formyl-3,4-methylenedioxy amphetamine; (with LAH) to ~~MOMA~~ (Shulgin and Shulgin, 1991)

* From MDA (with formic acid or ethyl formate) to ''N''-formyl-3,4-methylenedioxy amphetamine; (with LAH) to MDMA (Shulgin and Shulgin, 1991)

* From isosafrole (with formic acid, H202) to 3,4-methylenedioxyphenylacetone; (with Al, HgCl2, CH3NH2) to ~~MOMA~~ (Shulgin and Shulgin, 1991).

* From isosafrole (with formic acid, H202) to 3,4-methylenedioxyphenylacetone; (with Al, HgCl2, CH3NH2) to MDMA (Shulgin and Shulgin, 1991).

* (For the optical isomers) from piperonylacetone (with ''R''-(-)- (or ''S''-(+)-) α-methylbenzyl amine, Raney Ni) to ''R'',''R''- (or ''S'',''S'') ''N''-α-methylbenzyl-MOA; (with Pd, H2) to ''R''-(-)- (or ''S''-(+)-) ~~MOA~~; (with methyl formate) to ''R''-(+)- (or ''S''-(-) ''N''-formamido-~~MOA~~; (with LAH) to ''R''-(-) (or ''S''-(+)-) ~~MOMA~~ (Anderson et al., 1978a).

* (For the optical isomers) from piperonylacetone (with ''R''-(-)- (or ''S''-(+)-) α-methylbenzyl amine, Raney Ni) to ''R'',''R''- (or ''S'',''S'') ''N''-α-methylbenzyl-MOA; (with Pd, H2) to ''R''-(-)- (or ''S''-(+)-) MDA; (with methyl formate) to ''R''-(+)- (or ''S''-(-) ''N''-formamido-MDA; (with LAH) to ''R''-(-) (or ''S''-(+)-) MDMA (Anderson et al., 1978a).

== M. Swist, J. Wilamowski, A. Parczewski ==

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 === Synthesis ===
-* From safrole (with aqueous HBr) to 5-(2-bromopropyl)benzo-1,3-dioxole; (with methyl amine in EtOH) to MOMA (Merck, 1912; Bineicki and Krajewski, 1960).
+* From safrole (with aqueous HBr) to 5-(2-bromopropyl)benzo-1,3-dioxole; (with methyl amine in EtOH) to MDMA (Merck, 1912; Bineicki and Krajewski, 1960).
-* From 3,4-methylenedioxyphenylacetone (aka: piperonylacetone; with methylamine, sodium cyanoborohydride) to MOMA (Braun et al., 1980).
+* From 3,4-methylenedioxyphenylacetone (aka: piperonylacetone; with methylamine, sodium cyanoborohydride) to MDMA (Braun et al., 1980).
-* From MOA (with formic acid or ethyl formate) to ''N''-formyl-3,4-methylenedioxy amphetamine; (with LAH) to MOMA (Shulgin and Shulgin, 1991)
+* From MDA (with formic acid or ethyl formate) to ''N''-formyl-3,4-methylenedioxy amphetamine; (with LAH) to MDMA (Shulgin and Shulgin, 1991)
-* From isosafrole (with formic acid, H<sub>2</sub>0<sub>2</sub>) to 3,4-methylenedioxyphenylacetone; (with Al, HgCl<sub>2</sub>, CH<sub>3</sub>NH<sub>2</sub>) to MOMA (Shulgin and Shulgin, 1991).
+* From isosafrole (with formic acid, H<sub>2</sub>0<sub>2</sub>) to 3,4-methylenedioxyphenylacetone; (with Al, HgCl<sub>2</sub>, CH<sub>3</sub>NH<sub>2</sub>) to MDMA (Shulgin and Shulgin, 1991).
-* (For the optical isomers) from piperonylacetone (with ''R''-(-)- (or ''S''-(+)-) &alpha;-methylbenzyl amine, Raney Ni) to ''R'',''R''- (or ''S'',''S'') ''N''-&alpha;-methylbenzyl-MOA; (with Pd, H<sub>2</sub>) to ''R''-(-)- (or ''S''-(+)-) MOA; (with methyl formate) to ''R''-(+)- (or ''S''-(-) ''N''-formamido-MOA; (with LAH) to ''R''-(-) (or ''S''-(+)-) MOMA (Anderson et al., 1978a).
+* (For the optical isomers) from piperonylacetone (with ''R''-(-)- (or ''S''-(+)-) &alpha;-methylbenzyl amine, Raney Ni) to ''R'',''R''- (or ''S'',''S'') ''N''-&alpha;-methylbenzyl-MOA; (with Pd, H<sub>2</sub>) to ''R''-(-)- (or ''S''-(+)-) MDA; (with methyl formate) to ''R''-(+)- (or ''S''-(-) ''N''-formamido-MDA; (with LAH) to ''R''-(-) (or ''S''-(+)-) MDMA (Anderson et al., 1978a).
 == M. Swist, J. Wilamowski, A. Parczewski ==