2-FA: Difference between revisions

Line 6:

| ''[[2-FA/Summary|Summary sheet: 2-FA]]''

|}

'''2-Fluoroamphetamine''' ('''2-FA''') is a synthetic ring-substituted fluorinated [[chemical class::amphetamine]] compound that is commonly reported to be capable of producing classical [[psychoactive class::stimulant]] effects that are often compared to those produced by [[amphetamine|dextroamphetamine]] in duration, potency and potential effectiveness as a study aid or productivity enhancer.<ref>http://drugs.tripsit.me/2-fa | Tripsit Factsheets - 2FA</ref> It is one part of a series of modern [[designer drug|designer fluorinated amphetamine analogs]] that includes synthetic compounds like [[2-FMA]], [[3-FA]], [[3-FEA]] and [[4-FA]] which are known for their range of [[stimulant|stimulating]] and [[~~euphoria~~]]~~-producing~~ effects, many of which have been gaining popularity as [[research chemical]] substitutes for classical street [[stimulant]]s.{{citation needed}} Of these, 2-FA is considered to be [[amphetamine]]-like in its core properties and effects, with the exception of an apparent dose "ceiling" that is purportedly capable of discouraging abuse relative to ~~its parent compound amphetamine~~ as well as conferring on it [[nootropic]] properties.{{citation needed}}

'''2-Fluoroamphetamine''' ('''2-FA''') is a synthetic ring-substituted fluorinated [[chemical class::amphetamine]] compound that is commonly reported to be capable of producing classical [[psychoactive class::stimulant]] effects that are often compared to those produced by [[amphetamine|dextroamphetamine]] in duration, potency and potential effectiveness as a study aid or productivity enhancer.<ref>http://drugs.tripsit.me/2-fa | Tripsit Factsheets - 2FA</ref> It is one part of a series of modern [[designer drug|designer fluorinated amphetamine analogs]] that includes synthetic compounds like [[2-FMA]], [[3-FA]], [[3-FEA]] and [[4-FA]] which are known for their range of [[stimulant|stimulating]] and [[euphoric]] effects, many of which have been gaining popularity as [[research chemical]] substitutes for classical street [[stimulant]]s.{{citation needed}} Of these, 2-FA is considered to be most [[amphetamine]]-like in its core properties and effects, with the exception of an apparent "dose ceiling" that is purportedly capable of discouraging abuse relative to other stimulants as well as conferring on it [[nootropic]] properties.{{citation needed}}

2-FA is commonly taken ~~either~~ orally in line with the usage instruction of ~~prescription~~ stimulants used to treat ADHD. ~~More rarely, it is~~ taken via [[routes of administration|insufflation]] or vaporization ~~although it~~ has been reported to be highly unpleasant and toxic-feeling compared to its parent compound. Despite its popularity as a research chemical study aid, little is known about the potential toxicological effects that accompany its long-term use as a substitute for prescribed stimulants.

2-FA is commonly taken orally in line with the prescribed usage instruction of stimulants used to treat ADHD. While capable of being taken via [[routes of administration|insufflation]] or vaporization, this has been reported to be highly unpleasant and toxic-feeling compared to its parent compound. Despite its popularity as a research chemical study aid, little is known about the potential toxicological effects that accompany its long-term use as a substitute for prescribed stimulants.

2-FA is rarely found on the streets, but sometimes sold as a grey market [[research chemical]] through online vendors.<ref>Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs) (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/15639609</ref><ref>Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/20074881</ref>

==Chemistry==

[[File:~~Phenethylamine~~.png|thumb|right|~~245px~~|thumb|right|~~245px~~||Generic structure of a ~~phenethylamine~~ molecule]]

[[File:samphetamine.png|thumb|right|240px|thumb|right|240px||Generic structure of a amphetamine molecule]]

2-FA, or 2-Fluoroamphetamine, is a synthetic molecule of the [[amphetamine]] family. Molecules of the amphetamine class contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at R<sub>α</sub> (i.e. amphetamines are alpha-methylated phenethylamines). Unlike its close analogue [[2-FMA]], 2-FA does not contain a methyl group bound to the terminal amine R<sub>N</sub> of the amphetamine core, which renders it structurally and functionally similar to [[amphetamine]]. 2-FA is the 2-position fluorinated analogue of [[amphetamine]].

@@ Line 6: / Line 6: @@
 | ''[[2-FA/Summary|Summary sheet: 2-FA]]''
 |}
-'''2-Fluoroamphetamine''' ('''2-FA''') is a synthetic ring-substituted fluorinated [[chemical class::amphetamine]] compound that is commonly reported to be capable of producing classical [[psychoactive class::stimulant]] effects that are often compared to those produced by [[amphetamine|dextroamphetamine]] in duration, potency and potential effectiveness as a study aid or productivity enhancer.<ref>http://drugs.tripsit.me/2-fa | Tripsit Factsheets - 2FA</ref> It is one part of a series of modern [[designer drug|designer fluorinated amphetamine analogs]] that includes synthetic compounds like [[2-FMA]], [[3-FA]], [[3-FEA]] and [[4-FA]] which are known for their range of [[stimulant|stimulating]] and [[euphoria]]-producing effects, many of which have been gaining popularity as [[research chemical]] substitutes for classical street [[stimulant]]s.{{citation needed}} Of these, 2-FA is considered to be [[amphetamine]]-like in its core properties and effects, with the exception of an apparent dose "ceiling" that is purportedly capable of discouraging abuse relative to its parent compound amphetamine as well as conferring on it [[nootropic]] properties.{{citation needed}}
+'''2-Fluoroamphetamine''' ('''2-FA''') is a synthetic ring-substituted fluorinated [[chemical class::amphetamine]] compound that is commonly reported to be capable of producing classical [[psychoactive class::stimulant]] effects that are often compared to those produced by [[amphetamine|dextroamphetamine]] in duration, potency and potential effectiveness as a study aid or productivity enhancer.<ref>http://drugs.tripsit.me/2-fa | Tripsit Factsheets - 2FA</ref> It is one part of a series of modern [[designer drug|designer fluorinated amphetamine analogs]] that includes synthetic compounds like [[2-FMA]], [[3-FA]], [[3-FEA]] and [[4-FA]] which are known for their range of [[stimulant|stimulating]] and [[euphoric]] effects, many of which have been gaining popularity as [[research chemical]] substitutes for classical street [[stimulant]]s.{{citation needed}} Of these, 2-FA is considered to be most [[amphetamine]]-like in its core properties and effects, with the exception of an apparent "dose ceiling" that is purportedly capable of discouraging abuse relative to other stimulants as well as conferring on it [[nootropic]] properties.{{citation needed}}
--FA is commonly taken either orally in line with the usage instruction of prescription stimulants used to treat ADHD. More rarely, it is taken via [[routes of administration|insufflation]] or vaporization although it has been reported to be highly unpleasant and toxic-feeling compared to its parent compound. Despite its popularity as a research chemical study aid, little is known about the potential toxicological effects that accompany its long-term use as a substitute for prescribed stimulants.
+-FA is commonly taken orally in line with the prescribed usage instruction of stimulants used to treat ADHD. While capable of being taken via [[routes of administration|insufflation]] or vaporization, this has been reported to be highly unpleasant and toxic-feeling compared to its parent compound. Despite its popularity as a research chemical study aid, little is known about the potential toxicological effects that accompany its long-term use as a substitute for prescribed stimulants.
 -FA is rarely found on the streets, but sometimes sold as a grey market [[research chemical]] through online vendors.<ref>Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs) (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/15639609</ref><ref>Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/20074881</ref>
 ==Chemistry==
-[[File:Phenethylamine.png|thumb|right|245px|thumb|right|245px||Generic structure of a phenethylamine molecule]]
+[[File:samphetamine.png|thumb|right|240px|thumb|right|240px||Generic structure of a amphetamine molecule]]
 -FA, or 2-Fluoroamphetamine, is a synthetic molecule of the [[amphetamine]] family. Molecules of the amphetamine class contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at R<sub>α</sub> (i.e. amphetamines are alpha-methylated phenethylamines). Unlike its close analogue [[2-FMA]], 2-FA does not contain a methyl group bound to the terminal amine R<sub>N</sub> of the amphetamine core, which renders it structurally and functionally similar to [[amphetamine]]. 2-FA is the 2-position fluorinated analogue of [[amphetamine]].