Talk:Antidepressant: Difference between revisions

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'''~~Antidepressant~~''' is a type of drug ~~that is~~ used ~~in medicine~~ for treating depression ~~among other mental health issues like anxiety disorders~~.

An '''antidepressant''' is a type of psychiatric drug used for treating major depressive disorder (unipolar depression). It is worth noting that many of these agents are not effective for bipolar disorder-associated depression and that antipsychotics such as lurasidone (Latuda) and quetiapine (Seroquel) are used for this purpose.

==Types==

==Types of antidepressants==

===Selective serotonin reuptake inhibitors===

===Selective serotonin reuptake inhibitors (SSRIs)===

===Serotonin-norepinephrine reuptake ~~inhibitors~~===

:Selective serotonin reuptake inhibitors are believed to increase the level of extracellular [[serotonin]], therefore allowing more serotonin to be in the brain. The reason SSRIs are used for depression is because

===Serotonin modulators and stimulators===

===Serotonin-norepinephrine reuptake inhibitor (SNRIs)===

===Serotonin antagonists and reuptake inhibitors===

===Serotonin modulators and stimulators (SMSes)===

===Norepinephrine reuptake inhibitors===

===Serotonin antagonists and reuptake inhibitors (SARIs)===

===Tricyclic antidepressants===

===Norepinephrine reuptake inhibitors (NRIs)===

===Tetracyclic antidepressants===

:NRIs are believed to increase the level of extracellular [[norepinephrine]], therefore allowing more of it to be in the brain. Controversy has been sparked over the effectiveness of reboxetine, an NRI sold as Trintellix. <ref>"Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis." Multiple authors (2009) https://www.researchgate.net/profile/Andrea_Cipriani/publication/23967068_Comparative_efficacy_and_acceptability_of_12_new-generation_antidepressants_A_multiple-treatments_meta-analysis/links/00b7d5278b5bed4c17000000.pdf</ref>

===Monoamine Oxidase Inhibitors===

===Norepinephrine-dopamine reuptake inhibitors (NDRIs)===

:NDRIs are believed to increase the level of extracellular [[norepinephrine]] and [[dopamine]], therefore allowing more of these to be in the brain. Agents such as bupropion (Wellbutrin) have been found effective for MDD with little direct effect on serotonin, and therefore it can be hypothesized that other agents are effective for it. Bupropion and other NDRIs are also effective for depression with fatigue or sleepiness.

===Tricyclic antidepressants (TCAs)===

===Tetracyclic antidepressants (TeCAs)===

===Monoamine Oxidase Inhibitors (MAOIs)===

==Psychedelics for treating depression==

===~~Magic mushroom~~===

===Psilocybin mushrooms ("magic mushrooms")===

===Ketamine===

==References==

[[Category:Articles in talk page]]

@@ Line 1: / Line 1: @@
-'''Antidepressant''' is a type of drug that is used in medicine for treating depression among other mental health issues like anxiety disorders.
+An '''antidepressant''' is a type of psychiatric drug used for treating major depressive disorder (unipolar depression). It is worth noting that many of these agents are not effective for bipolar disorder-associated depression and that antipsychotics such as lurasidone (Latuda) and quetiapine (Seroquel) are used for this purpose.
-==Types==
+==Types of antidepressants==
-===Selective serotonin reuptake inhibitors===
+===Selective serotonin reuptake inhibitors (SSRIs)===
-===Serotonin-norepinephrine reuptake inhibitors===
+:Selective serotonin reuptake inhibitors are believed to increase the level of extracellular [[serotonin]], therefore allowing more serotonin to be in the brain. The reason SSRIs are used for depression is because
-===Serotonin modulators and stimulators===
+===Serotonin-norepinephrine reuptake inhibitor (SNRIs)===
-===Serotonin antagonists and reuptake inhibitors===
+===Serotonin modulators and stimulators (SMSes)===
-===Norepinephrine reuptake inhibitors===
+===Serotonin antagonists and reuptake inhibitors (SARIs)===
-===Tricyclic antidepressants===
+===Norepinephrine reuptake inhibitors (NRIs)===
-===Tetracyclic antidepressants===
+:NRIs are believed to increase the level of extracellular [[norepinephrine]], therefore allowing more of it to be in the brain. Controversy has been sparked over the effectiveness of reboxetine, an NRI sold as Trintellix. <ref>"Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis." Multiple authors (2009) https://www.researchgate.net/profile/Andrea_Cipriani/publication/23967068_Comparative_efficacy_and_acceptability_of_12_new-generation_antidepressants_A_multiple-treatments_meta-analysis/links/00b7d5278b5bed4c17000000.pdf</ref>
-===Monoamine Oxidase Inhibitors===
+===Norepinephrine-dopamine reuptake inhibitors (NDRIs)===
+:NDRIs are believed to increase the level of extracellular [[norepinephrine]] and [[dopamine]], therefore allowing more of these to be in the brain. Agents such as bupropion (Wellbutrin) have been found effective for MDD with little direct effect on serotonin, and therefore it can be hypothesized that other agents are effective for it. Bupropion and other NDRIs are also effective for depression with fatigue or sleepiness.
+===Tricyclic antidepressants (TCAs)===
+===Tetracyclic antidepressants (TeCAs)===
+===Monoamine Oxidase Inhibitors (MAOIs)===
 ==Psychedelics for treating depression==
-===Magic mushroom===
+===Psilocybin mushrooms ("magic mushrooms")===
 ===Ketamine===
+==References==
 [[Category:Articles in talk page]]