3-FEA: Difference between revisions

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The toxicity and long-term health effects of recreational 3-FEA use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because 3-FEA has an extremely short history of human usage, becoming available only in mid-2016. Anecdotal evidence from people who have tried 3-FEA within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

Due to its putative serotonin-releasing and [[entactogen]]ic properties, it is likely that 3-FEA may display excess activity at the 5-HT2b receptor, which like [[MDMA]] and fenfluramine would make it would be cardiotoxic with long-term use, as seen in other 5-HT2b agonists such as [https://en.wikipedia.org/wiki/Fenfluramine fenfluramine] and [[MDMA]]].

Due to its putative serotonin-releasing and [[entactogen]]ic properties, it is likely that 3-FEA may display excess activity at the 5-HT2b receptor, which like [[MDMA]] and fenfluramine would make it would be cardiotoxic with long-term use, as seen in other 5-HT2b agonists such as [https://en.wikipedia.org/wiki/Fenfluramine fenfluramine] and [[MDMA]].

It is perhaps worth noting that in the field of medicinal chemistry, the fluorine substitution is sometimes seen as desirable in central nervous system pharmaceutical agents, and is a common practice due to the corresponding increase in lipophilicity granted by the substitute.<ref>Fluorine substituent effects (on bioactivity) | http://www.sciencedirect.com/science/article/pii/S002211390100375X</ref>

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 The toxicity and long-term health effects of recreational 3-FEA use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because 3-FEA has an extremely short history of human usage, becoming available only in mid-2016. Anecdotal evidence from people who have tried 3-FEA within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).
-Due to its putative serotonin-releasing and [[entactogen]]ic properties, it is likely that 3-FEA may display excess activity at the 5-HT2b receptor, which like [[MDMA]] and fenfluramine would make it would be cardiotoxic with long-term use, as seen in other 5-HT2b agonists such as [https://en.wikipedia.org/wiki/Fenfluramine fenfluramine] and [[MDMA]]].
+Due to its putative serotonin-releasing and [[entactogen]]ic properties, it is likely that 3-FEA may display excess activity at the 5-HT2b receptor, which like [[MDMA]] and fenfluramine would make it would be cardiotoxic with long-term use, as seen in other 5-HT2b agonists such as [https://en.wikipedia.org/wiki/Fenfluramine fenfluramine] and [[MDMA]].
 It is perhaps worth noting that in the field of medicinal chemistry, the fluorine substitution is sometimes seen as desirable in central nervous system pharmaceutical agents, and is a common practice due to the corresponding increase in lipophilicity granted by the substitute.<ref>Fluorine substituent effects (on bioactivity) | http://www.sciencedirect.com/science/article/pii/S002211390100375X</ref>