F-Phenibut: Difference between revisions

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[https://en.wikipedia.org/wiki/Baclofen baclofen], [[pregabalin]], [[gabapentin]], and [https://en.wikipedia.org/wiki/Gamma-Amino-beta-hydroxybutyric_acid GABOB].<ref name="one">Lapin, I. (2001). "Phenibut (beta-phenyl-GABA): A tranquilizer and nootropic drug" (pdf). CNS Drug Reviews | http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2001.tb00211.x/pdf</ref><ref>"Wyllie's Treatment of Epilepsy: Principles and Practice" | https://books.google.co.uk/books?id=j9t6Qg0kkuUC&pg=RA1-PA423&redir_esc=y#v=onepage&q&f=false</ref><ref>"Practical Management of Pain. Elsevier Health Sciences" | https://books.google.co.uk/books?id=kfcDAQAAQBAJ&pg=PA1006&redir_esc=y#v=onepage&q&f=false</ref> Fluorophenibut, like its parent compound, is a derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid ([[GABA]]), but with an addition of a phenyl ring that allows it to cross the blood–brain barrier.<ref name="one">Lapin, I. (2001). "Phenibut (beta-phenyl-GABA): A tranquilizer and nootropic drug" (pdf). CNS Drug Reviews | http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2001.tb00211.x/pdf</ref>

==Chemistry==

F-~~phenibut~~ is a derivative of GABA with a fluorine-substituted phenyl group in the β-position. It is a chiral molecule and thus has two potential configurations as (R)- and (S)-enantiomers.<ref>"Comparative pharmacological activity of optical isomers of phenibut." | https://www.ncbi.nlm.nih.gov/pubmed/18275958</ref> It has an almost identical chemical structure to baclofen (only replacing a chlorine with a fluorine atom in the para-position of the phenyl group).<ref>On neurotransmitter mechanisms of reinforcement and internal inhibition. | https://www.ncbi.nlm.nih.gov/pubmed/2431377</ref> Additionally, the widely prescribed gabapentinoid [[pregabalin]] also possesses a similar structure as phenibut, except that the phenyl group is instead replaced with an isobutyl group.

Like Phenibut, F-Phenibut is a derivative of GABA, except with a fluorine-substituted phenyl group in the β-position of the molecule. It is a chiral molecule and thus has two potential configurations as (R)- and (S)-enantiomers.<ref>"Comparative pharmacological activity of optical isomers of phenibut." | https://www.ncbi.nlm.nih.gov/pubmed/18275958</ref> It has an almost identical chemical structure to baclofen (only replacing a chlorine with a fluorine atom in the para-position of the phenyl group).<ref>On neurotransmitter mechanisms of reinforcement and internal inhibition. | https://www.ncbi.nlm.nih.gov/pubmed/2431377</ref> Additionally, the widely prescribed gabapentinoid [[pregabalin]] also possesses a similar structure as phenibut, except that the phenyl group is instead replaced with an isobutyl group.

==Pharmacology==

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 [https://en.wikipedia.org/wiki/Baclofen baclofen], [[pregabalin]], [[gabapentin]], and [https://en.wikipedia.org/wiki/Gamma-Amino-beta-hydroxybutyric_acid GABOB].<ref name="one">Lapin, I. (2001). "Phenibut (beta-phenyl-GABA): A tranquilizer and nootropic drug" (pdf). CNS Drug Reviews | http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2001.tb00211.x/pdf</ref><ref>"Wyllie's Treatment of Epilepsy: Principles and Practice" | https://books.google.co.uk/books?id=j9t6Qg0kkuUC&pg=RA1-PA423&redir_esc=y#v=onepage&q&f=false</ref><ref>"Practical Management of Pain. Elsevier Health Sciences" | https://books.google.co.uk/books?id=kfcDAQAAQBAJ&pg=PA1006&redir_esc=y#v=onepage&q&f=false</ref> Fluorophenibut, like its parent compound, is a derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid ([[GABA]]), but with an addition of a phenyl ring that allows it to cross the blood–brain barrier.<ref name="one">Lapin, I. (2001). "Phenibut (beta-phenyl-GABA): A tranquilizer and nootropic drug" (pdf). CNS Drug Reviews | http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2001.tb00211.x/pdf</ref>
 ==Chemistry==
-F-phenibut is a derivative of GABA with a fluorine-substituted phenyl group in the β-position. It is a chiral molecule and thus has two potential configurations as (R)- and (S)-enantiomers.<ref>"Comparative pharmacological activity of optical isomers of phenibut." | https://www.ncbi.nlm.nih.gov/pubmed/18275958</ref> It has an almost identical chemical structure to baclofen (only replacing a chlorine with a fluorine atom in the para-position of the phenyl group).<ref>On neurotransmitter mechanisms of reinforcement and internal inhibition. | https://www.ncbi.nlm.nih.gov/pubmed/2431377</ref> Additionally, the widely prescribed gabapentinoid [[pregabalin]] also possesses a similar structure as phenibut, except that the phenyl group is instead replaced with an isobutyl group.
+Like Phenibut, F-Phenibut is a derivative of GABA, except with a fluorine-substituted phenyl group in the β-position of the molecule. It is a chiral molecule and thus has two potential configurations as (R)- and (S)-enantiomers.<ref>"Comparative pharmacological activity of optical isomers of phenibut." | https://www.ncbi.nlm.nih.gov/pubmed/18275958</ref> It has an almost identical chemical structure to baclofen (only replacing a chlorine with a fluorine atom in the para-position of the phenyl group).<ref>On neurotransmitter mechanisms of reinforcement and internal inhibition. | https://www.ncbi.nlm.nih.gov/pubmed/2431377</ref> Additionally, the widely prescribed gabapentinoid [[pregabalin]] also possesses a similar structure as phenibut, except that the phenyl group is instead replaced with an isobutyl group.
 ==Pharmacology==