Haloperidol: Difference between revisions

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==Pharmacology==

As an typical antipsychotic, haloperidol has a diverse pharmacological profile. Primarily, haloperidol acts on [[dopamine]] D2 [[receptor]]s as an [[antagonist]], as well as a D3 inverse [[agonist]]. Haloperidol is also an antagonist of the [[serotonin |5-HT]]2A receptor, although this effect is not as powerful as that of [[quetiapine]]. Unlike many antipsychotcs, haloperidol has negligible affinity for the muscarinic acetylcholine receptors as well as the histamine receptors, which results in less sedation, weight gain and hypotension.<ref>H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs | http://www.nature.com/npp/journal/v28/n3/full/1300027a.html</ref>

As a typical antipsychotic, haloperidol has a diverse pharmacological profile. Primarily, haloperidol acts on [[dopamine]] D2 [[receptor]]s as an [[antagonist]], as well as a D3 inverse [[agonist]]. Haloperidol is also an antagonist of the [[serotonin |5-HT]]2A receptor, although this effect is not as powerful as that of [[quetiapine]]. Unlike many antipsychotcs, haloperidol has negligible affinity for the muscarinic acetylcholine receptors as well as the histamine receptors, which results in less sedation, weight gain and hypotension.<ref>H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs | http://www.nature.com/npp/journal/v28/n3/full/1300027a.html</ref>

==Subjective effects==

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 ==Pharmacology==
 {{pharmacology}}
-As an typical antipsychotic, haloperidol has a diverse pharmacological profile. Primarily, haloperidol acts on [[dopamine]] D<sub>2</sub> [[receptor]]s as an [[antagonist]], as well as a D<sub>3</sub> inverse [[agonist]]. Haloperidol is also an antagonist of the [[serotonin |5-HT]]<sub>2A</sub> receptor, although this effect is not as powerful as that of [[quetiapine]]. Unlike many antipsychotcs, haloperidol has negligible affinity for the muscarinic acetylcholine receptors as well as the histamine receptors, which results in less sedation, weight gain and hypotension.<ref>H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs | http://www.nature.com/npp/journal/v28/n3/full/1300027a.html</ref>
+As a typical antipsychotic, haloperidol has a diverse pharmacological profile. Primarily, haloperidol acts on [[dopamine]] D<sub>2</sub> [[receptor]]s as an [[antagonist]], as well as a D<sub>3</sub> inverse [[agonist]]. Haloperidol is also an antagonist of the [[serotonin |5-HT]]<sub>2A</sub> receptor, although this effect is not as powerful as that of [[quetiapine]]. Unlike many antipsychotcs, haloperidol has negligible affinity for the muscarinic acetylcholine receptors as well as the histamine receptors, which results in less sedation, weight gain and hypotension.<ref>H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs | http://www.nature.com/npp/journal/v28/n3/full/1300027a.html</ref>
 ==Subjective effects==