6-APDB: Difference between revisions

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==Pharmacology==

6-APDB acts as a [[releasing agent]] and triple [[reuptake inhibitor]] of the monoamine [[neurotransmitters]] known as [[serotonin]], [[dopamine]] and [[noradrenaline]]<ref>Effects of 6-APDB on the release of monoamines from rat brain slices https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582025/</ref> which are the global [[neurotransmitters]] that modulate the brain's ability to feel pleasure, motivation, reward, planning, attention and focus. This is done by promoting the release and inhibiting the reuptake and reabsorption of the neurotransmitters after they have performed their function of transmitting a neural impulse through release into the synaptic cleft, essentially allowing them to accumulate and render them liable for immediate reuse.

6-APDB acts as a [[releasing agent]] and triple [[reuptake inhibitor]] of the monoamine [[neurotransmitters]] known as [[serotonin]], [[dopamine]] and [[noradrenaline]]<ref>Effects of 6-APDB on the release of monoamines from rat brain slices https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582025/</ref> which are the global [[neurotransmitters]] that modulate the brain's ability to feel pleasure, motivation, reward, planning, attention and focus. This is done by promoting the release and inhibiting the reuptake and reabsorption of the neurotransmitters after they have performed their function of transmitting a neural impulse through release into the synaptic cleft, essentially allowing them to accumulate and render them liable for immediate reuse. The net result is excitation in a manner which causes a combination of physically stimulating, relaxing, disinhibiting and euphoric effects.<ref>New Insights into the Mechanism of Action of Amphetamines | http://www.annualreviews.org/doi/abs/10.1146/annurev.pharmtox.47.120505.105140</ref>

The ~~net result~~ is ~~excitation~~ in ~~a manner which causes a combination of physically stimulating, relaxing, disinhibiting~~ and ~~euphoric effects.<ref>New Insights into the Mechanism of Action of Amphetamines | http://www.annualreviews.org/doi/abs/10.1146/annurev.pharmtox.47.120505~~.~~105140</ref>~~

The unsaturated benzofuran derivative [[6-APB]], or 6-(2-aminopropyl)benzofuran is also known, but the difference in pharmacological effects between 6-APB and 6-APDB has yet to be fully elucidated.

==Subjective effects==

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 ==Pharmacology==
--APDB acts as a [[releasing agent]] and triple [[reuptake inhibitor]] of the monoamine [[neurotransmitters]] known as [[serotonin]], [[dopamine]] and [[noradrenaline]]<ref>Effects of 6-APDB on the release of monoamines from rat brain slices https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582025/</ref> which are the global [[neurotransmitters]] that modulate the brain's ability to feel pleasure, motivation, reward, planning, attention and focus. This is done by promoting the release and inhibiting the reuptake and reabsorption of the neurotransmitters after they have performed their function of transmitting a neural impulse through release into the synaptic cleft, essentially allowing them to accumulate and render them liable for immediate reuse.
+-APDB acts as a [[releasing agent]] and triple [[reuptake inhibitor]] of the monoamine [[neurotransmitters]] known as [[serotonin]], [[dopamine]] and [[noradrenaline]]<ref>Effects of 6-APDB on the release of monoamines from rat brain slices https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582025/</ref> which are the global [[neurotransmitters]] that modulate the brain's ability to feel pleasure, motivation, reward, planning, attention and focus. This is done by promoting the release and inhibiting the reuptake and reabsorption of the neurotransmitters after they have performed their function of transmitting a neural impulse through release into the synaptic cleft, essentially allowing them to accumulate and render them liable for immediate reuse. The net result is excitation in a manner which causes a combination of physically stimulating, relaxing, disinhibiting and euphoric effects.<ref>New Insights into the Mechanism of Action of Amphetamines | http://www.annualreviews.org/doi/abs/10.1146/annurev.pharmtox.47.120505.105140</ref>
-The net result is excitation in a manner which causes a combination of physically stimulating, relaxing, disinhibiting and euphoric effects.<ref>New Insights into the Mechanism of Action of Amphetamines | http://www.annualreviews.org/doi/abs/10.1146/annurev.pharmtox.47.120505.105140</ref>
+The unsaturated benzofuran derivative [[6-APB]], or 6-(2-aminopropyl)benzofuran is also known, but the difference in pharmacological effects between 6-APB and 6-APDB has yet to be fully elucidated.
 ==Subjective effects==