Serotonin: Difference between revisions

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A serotonin [[agonist|full agonist]] is a chemical that binds to and activates a serotonin [[receptor]] and triggers a response, displaying full efficacy at that receptor.

A few psychedelic ~~drugs~~ are full agonists of the 5-HT2A receptor; among them are [[25I-NBOMe]] and [[Bromo-DragonFLY]].

A few psychedelic substances are full agonists of the 5-HT2A receptor; among them are [[25I-NBOMe]] and [[Bromo-DragonFLY]].

====Partial agonists====

A serotonin [[Agonist#Agonists|partial agonist]] is a drug that binds to and activates a serotonin receptor, but only has partial efficacy at the receptor relative to a full agonist.

Most classical psychedelic ~~drugs~~ are partial agonists of the 5-HT2A receptor; among them are [[LSD]], [[psilocin]] and [[mescaline]]. Many antidepressants, anxiolytics/anti-anxiety drugs, and cluster headache medicines are partial serotonin receptor agonists.

Most classical psychedelic substances are partial agonists of the 5-HT2A receptor; among them are [[LSD]], [[psilocin]] and [[mescaline]]. Many antidepressants, anxiolytics/anti-anxiety drugs, and cluster headache medicines are partial serotonin receptor agonists.

====Inverse agonists====

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A serotonin [[Releasing Agent|releasing agent]] is a drug that induces the release of serotonin from the presynaptic neuron into the synapse, leading to an increase in the extracellular concentrations of serotonin.

Many recreational ~~drugs~~ are serotonin releasing agents; among them are [[MDMA]], [[MDA]] and [[mephedrone]]. Many analgesics/pain-relievers and appetite suppressants are also serotonin releasing agents.

Many recreational substances are serotonin releasing agents; among them are [[MDMA]], [[MDA]] and [[mephedrone]]. Many analgesics/pain-relievers and appetite suppressants are also serotonin releasing agents.

====Reuptake inhibitor====

A serotonin [[reuptake inhibitor]] inhibits the reabsorption of serotonin into the pre-synaptic neuron. Serotonin reuptake inhibitors do this by inhibiting the serotonin transporter, or SERT protein.

Many antidepressants such as venlafaxine (Effexor), citalopram (Celexa) and amitriptyline are serotonin reuptake inhibitors. Many recreational ~~drugs~~ like [[cocaine]] and [[tramadol]] are also serotonin reuptake inhibitors.

Many antidepressants such as venlafaxine (Effexor), citalopram (Celexa) and amitriptyline are serotonin reuptake inhibitors. Many recreational substances like [[cocaine]] and [[tramadol]] are also serotonin reuptake inhibitors.

====Antagonists====

@@ Line 16: / Line 16: @@
 A serotonin [[agonist|full agonist]] is a chemical that binds to and activates a serotonin [[receptor]] and triggers a response, displaying full efficacy at that receptor.
-A few psychedelic drugs are full agonists of the 5-HT<sub>2A</sub> receptor; among them are [[25I-NBOMe]] and [[Bromo-DragonFLY]].
+A few psychedelic substances are full agonists of the 5-HT<sub>2A</sub> receptor; among them are [[25I-NBOMe]] and [[Bromo-DragonFLY]].
 ====Partial agonists====
 A serotonin [[Agonist#Agonists|partial agonist]] is a drug that binds to and activates a serotonin receptor, but only has partial efficacy at the receptor relative to a full agonist.
-Most classical psychedelic drugs are partial agonists of the 5-HT<sub>2A</sub> receptor; among them are [[LSD]], [[psilocin]] and [[mescaline]]. Many antidepressants, anxiolytics/anti-anxiety drugs, and cluster headache medicines are partial serotonin receptor agonists.
+Most classical psychedelic substances are partial agonists of the 5-HT<sub>2A</sub> receptor; among them are [[LSD]], [[psilocin]] and [[mescaline]]. Many antidepressants, anxiolytics/anti-anxiety drugs, and cluster headache medicines are partial serotonin receptor agonists.
 ====Inverse agonists====
@@ Line 30: / Line 30: @@
 A serotonin [[Releasing Agent|releasing agent]] is a drug that induces the release of serotonin from the presynaptic neuron into the synapse, leading to an increase in the extracellular concentrations of serotonin.
-Many recreational drugs are serotonin releasing agents; among them are [[MDMA]], [[MDA]] and [[mephedrone]]. Many analgesics/pain-relievers and appetite suppressants are also serotonin releasing agents.
+Many recreational substances are serotonin releasing agents; among them are [[MDMA]], [[MDA]] and [[mephedrone]]. Many analgesics/pain-relievers and appetite suppressants are also serotonin releasing agents.
 ====Reuptake inhibitor====
 A serotonin [[reuptake inhibitor]] inhibits the reabsorption of serotonin into the pre-synaptic neuron. Serotonin reuptake inhibitors do this by inhibiting the serotonin transporter, or SERT protein.
-Many antidepressants such as venlafaxine (Effexor), citalopram (Celexa) and amitriptyline are serotonin reuptake inhibitors. Many recreational drugs like [[cocaine]] and [[tramadol]] are also serotonin reuptake inhibitors.
+Many antidepressants such as venlafaxine (Effexor), citalopram (Celexa) and amitriptyline are serotonin reuptake inhibitors. Many recreational substances like [[cocaine]] and [[tramadol]] are also serotonin reuptake inhibitors.
 ====Antagonists====