Isomer: Difference between revisions

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Most biological molecules (proteins, sugars, etc.) are present in only one of many chiral forms, so different enantiomers of a chiral drug molecule bind differently (or not at all) to target receptors. One enantiomer of a drug may have a desired beneficial effect while the other may cause serious and undesired side effects, or sometimes even beneficial but entirely different effects.

One example of this is with the [[dissociative]] drug [[DXM]]. DXM, or dextromethorphan, is the isomer that rotates clockwise in plane-polarised light. It has antitussive (cough suppressant) and dissociative effects. Levomethorphan is the isomer that rotates anti-clockwise in plane-polarised light. This difference in rotation ~~leads to different~~ effects ~~to DXM~~; levomethorphan is an opioid painkiller.

One example of this is with the [[dissociative]] drug [[DXM]]. DXM, or dextromethorphan, is the isomer that rotates clockwise in plane-polarised light. It has antitussive (cough suppressant) and dissociative effects. Levomethorphan is the isomer that rotates anti-clockwise in plane-polarised light. This difference in rotation can radically alter the effects and character of the drug; for example, levomethorphan is an [[opioid]] painkiller.

Revision as of 22:04, 1 November 2016 view source >Unity m →Chirality ← Older edit		Revision as of 05:57, 9 December 2016 view source >Unity →Chirality Newer edit →
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	Most biological molecules (proteins, sugars, etc.) are present in only one of many chiral forms, so different enantiomers of a chiral drug molecule bind differently (or not at all) to target receptors. One enantiomer of a drug may have a desired beneficial effect while the other may cause serious and undesired side effects, or sometimes even beneficial but entirely different effects.		Most biological molecules (proteins, sugars, etc.) are present in only one of many chiral forms, so different enantiomers of a chiral drug molecule bind differently (or not at all) to target receptors. One enantiomer of a drug may have a desired beneficial effect while the other may cause serious and undesired side effects, or sometimes even beneficial but entirely different effects.

	One example of this is with the [[dissociative]] drug [[DXM]]. DXM, or dextromethorphan, is the isomer that rotates clockwise in plane-polarised light. It has antitussive (cough suppressant) and dissociative effects. Levomethorphan is the isomer that rotates anti-clockwise in plane-polarised light. This difference in rotation ~~leads to different~~ effects ~~to DXM~~; levomethorphan is an opioid painkiller.		One example of this is with the [[dissociative]] drug [[DXM]]. DXM, or dextromethorphan, is the isomer that rotates clockwise in plane-polarised light. It has antitussive (cough suppressant) and dissociative effects. Levomethorphan is the isomer that rotates anti-clockwise in plane-polarised light. This difference in rotation can radically alter the effects and character of the drug; for example, levomethorphan is an [[opioid]] painkiller.