5-Hydroxytryptophan: Difference between revisions

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'''5-Hydroxytryptophan''', also known as '''5-HTP''' and '''oxitriptan''', is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitters [[serotonin]] and [[melatonin]] from [[tryptophan]]. It is available over the counter in the United States, United Kingdom, and Canada as a dietary supplement and often used as an [[antidepressant]], sleep aid, and appetite suppressant. In some European countries, it is marketed as a prescription drug for the treatment of major depression.<ref>https://books.google.com/books?id=5GpcTQD_L2oC&lpg=PA1528&pg=PA773&hl=en#v=onepage&q&f=false | Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.</ref>

5-HTP is also used by users of [[MDMA]] to reduce the negative [[MDMA#After_effects|after effects]] that occur during the drug's [[duration|come down]] period, including [[anxiety]], [[depression]], and [[cognitive fatigue]].<ref>http://www.sciencedirect.com/science/article/pii/S0306452207006732 | Wang, X.; Baumann, M. H.; Dersch, C. M.; Rothman, R. B. (2007-08-10). "Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of l-5-hydroxytryptophan". Neuroscience. 148 (1): 212–220. doi:10.1016/j.neuroscience.2007.05.024. PMID 17629409.</ref> Since 5-HTP is a precursor for the neurotransmitter [[serotonin]] and MDMA depletes serotonin levels in the brain, it is believed that taking 5-HTP after coming down will speed the production of serotonin. 5-HTP should not be taken until 12 hours after the MDMA was last dosed because combining the two drugs could result in a potentially life-threatening condition called [[serotonin syndrome]].

5-HTP is also used by users of [[MDMA]] and other serotonin-releasing agents to reduce the negative [[MDMA#After_effects|after effects]] that occur during the drug's [[duration|come down]] period, including [[anxiety]], [[depression]], and [[cognitive fatigue]].<ref>http://www.sciencedirect.com/science/article/pii/S0306452207006732 | Wang, X.; Baumann, M. H.; Dersch, C. M.; Rothman, R. B. (2007-08-10). "Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of l-5-hydroxytryptophan". Neuroscience. 148 (1): 212–220. doi:10.1016/j.neuroscience.2007.05.024. PMID 17629409.</ref> Since 5-HTP is a precursor for the neurotransmitter [[serotonin]] and MDMA depletes serotonin levels in the brain, it is believed that taking 5-HTP after coming down will speed the production of serotonin. 5-HTP should not be taken until 12 hours after the MDMA was last dosed because combining the two drugs could result in a potentially life-threatening condition called [[serotonin syndrome]].

==Chemistry==

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 '''5-Hydroxytryptophan''', also known as '''5-HTP''' and '''oxitriptan''', is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitters [[serotonin]] and [[melatonin]] from [[tryptophan]]. It is available over the counter in the United States, United Kingdom, and Canada as a dietary supplement and often used as an [[antidepressant]], sleep aid, and appetite suppressant. In some European countries, it is marketed as a prescription drug for the treatment of major depression.<ref>https://books.google.com/books?id=5GpcTQD_L2oC&lpg=PA1528&pg=PA773&hl=en#v=onepage&q&f=false | Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.</ref>
--HTP is also used by users of [[MDMA]] to reduce the negative [[MDMA#After_effects|after effects]] that occur during the drug's [[duration|come down]] period, including [[anxiety]], [[depression]], and [[cognitive fatigue]].<ref>http://www.sciencedirect.com/science/article/pii/S0306452207006732 | Wang, X.; Baumann, M. H.; Dersch, C. M.; Rothman, R. B. (2007-08-10). "Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of l-5-hydroxytryptophan". Neuroscience. 148 (1): 212–220. doi:10.1016/j.neuroscience.2007.05.024. PMID 17629409.</ref> Since 5-HTP is a precursor for the neurotransmitter [[serotonin]] and MDMA depletes serotonin levels in the brain, it is believed that taking 5-HTP after coming down will speed the production of serotonin. 5-HTP should not be taken until 12 hours after the MDMA was last dosed because combining the two drugs could result in a potentially life-threatening condition called [[serotonin syndrome]].
+-HTP is also used by users of [[MDMA]] and other serotonin-releasing agents to reduce the negative [[MDMA#After_effects|after effects]] that occur during the drug's [[duration|come down]] period, including [[anxiety]], [[depression]], and [[cognitive fatigue]].<ref>http://www.sciencedirect.com/science/article/pii/S0306452207006732 | Wang, X.; Baumann, M. H.; Dersch, C. M.; Rothman, R. B. (2007-08-10). "Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of l-5-hydroxytryptophan". Neuroscience. 148 (1): 212–220. doi:10.1016/j.neuroscience.2007.05.024. PMID 17629409.</ref> Since 5-HTP is a precursor for the neurotransmitter [[serotonin]] and MDMA depletes serotonin levels in the brain, it is believed that taking 5-HTP after coming down will speed the production of serotonin. 5-HTP should not be taken until 12 hours after the MDMA was last dosed because combining the two drugs could result in a potentially life-threatening condition called [[serotonin syndrome]].
 ==Chemistry==
 {{chemistry}}