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5-Hydroxytryptophan: Difference between revisions
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==Pharmacology== | ==Pharmacology== | ||
The psychoactive action of 5-HTP is derived from its increase in production of serotonin in central nervous system tissue. 5-HTP is decarboxylated to serotonin (5-hydroxytryptamine or 5-HT) by the enzyme aromatic-L-amino-acid decarboxylase with the help of vitamin B6.<ref>https://www.ncbi.nlm.nih.gov/pubmed/6983619 | Effect of pyridoxal phosphate deficiency on aromatic L-amino acid decarboxylase activity with L-DOPA and L-5-hydroxytryptophan as substrates in rats.</ref> This reaction occurs both in nervous tissue and in the liver.<ref>https://www.ncbi.nlm.nih.gov/pubmed/6974228 | Characteristics of dihydroxyphenylalanine/5-hydroxytryptophan decarboxylase activity in brain and liver of cat.</ref> 5-HTP crosses the blood–brain barrier,<ref>https://www.ncbi.nlm.nih.gov/pubmed/18445233 | Augmented brain 5-HT crosses the blood-brain barrier through the 5-HT transporter in rat.</ref> while 5-HT does not. | The psychoactive action of 5-HTP is derived from its increase in production of serotonin in central nervous system tissue. 5-HTP is decarboxylated to serotonin (5-hydroxytryptamine or 5-HT) by the enzyme aromatic-L-amino-acid decarboxylase with the help of vitamin B6.<ref>https://www.ncbi.nlm.nih.gov/pubmed/6983619 | Effect of pyridoxal phosphate deficiency on aromatic L-amino acid decarboxylase activity with L-DOPA and L-5-hydroxytryptophan as substrates in rats.</ref> This reaction occurs both in nervous tissue and in the liver.<ref>https://www.ncbi.nlm.nih.gov/pubmed/6974228 | Characteristics of dihydroxyphenylalanine/5-hydroxytryptophan decarboxylase activity in brain and liver of cat.</ref> 5-HTP crosses the blood–brain barrier,<ref>https://www.ncbi.nlm.nih.gov/pubmed/18445233 | Augmented brain 5-HT crosses the blood-brain barrier through the 5-HT transporter in rat.</ref> while 5-HT does not. | ||
==Subjective effects== | |||
{{EffectStub}} | |||
===Physical effects=== | |||
For some individuals, 5-HTP can occasionally cause the following side effects (although rare). | |||
*'''[[Heartburn]]''' | |||
*'''[[Stomach bloating]]''' | |||
*'''[[Stomach pain]]''' | |||
*'''[[Nausea]] and vomiting''' | |||
*'''[[Diarrhea]] | |||
==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
Due to the conversion of 5-HTP into serotonin by the liver, there may be a significant risk of heart valve disease from serotonin's effect on the heart.<ref>https://www.ncbi.nlm.nih.gov/pubmed/15781732 | Long-term serotonin administration induces heart valve disease in rats.</ref><ref>https://www.ncbi.nlm.nih.gov/pubmed/12466135 | Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells.</ref> | Due to the conversion of 5-HTP into serotonin by the liver, there may be a significant risk of heart valve disease from serotonin's effect on the heart.<ref>https://www.ncbi.nlm.nih.gov/pubmed/15781732 | Long-term serotonin administration induces heart valve disease in rats.</ref><ref>https://www.ncbi.nlm.nih.gov/pubmed/12466135 | Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells.</ref> | ||