5-Hydroxytryptophan: Difference between revisions

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5-HTP is also used by users of [[MDMA]] to reduce the negative [[MDMA#After_effects|after effects]] that occur during the drug's [[duration|come down]] period, including [[anxiety]], [[depression]], and [[cognitive fatigue]].<ref>http://www.sciencedirect.com/science/article/pii/S0306452207006732 | Wang, X.; Baumann, M. H.; Dersch, C. M.; Rothman, R. B. (2007-08-10). "Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of l-5-hydroxytryptophan". Neuroscience. 148 (1): 212–220. doi:10.1016/j.neuroscience.2007.05.024. PMID 17629409.</ref> Since 5-HTP is a precursor for the neurotransmitter [[serotonin]] and MDMA depletes serotonin levels in the brain, it is believed that taking 5-HTP after coming down will speed the production of serotonin. 5-HTP should not be taken until 12 hours after the MDMA was last dosed because combining the two drugs could result in a potentially life-threatening condition called [[serotonin syndrome]].

==Toxicity and harm potential==

Due to the conversion of 5-HTP into serotonin by the liver, there may be a significant risk of heart valve disease from serotonin's effect on the heart.[15][16]

It has been suggested that 5-HTP may cause eosinophilia-myalgia syndrome (EMS), a serious condition which results in extreme muscle tenderness, myalgia, and blood abnormalities. However, there is evidence to show that EMS was likely caused by a contaminant in certain 5-HTP supplements.[17]

===Dangerous interactions===

When combined with antidepressants of the MAOI or SSRI class, high doses of 5-HTP can cause acute serotonin syndrome in rats.[8][9] In humans, 5-HTP has never been clinically associated with serotonin syndrome, although 5-HTP can precipitate mania when added to a MAOI.[10]

==See also==

*[[Serotonin syndrome]]

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 -HTP is also used by users of [[MDMA]] to reduce the negative [[MDMA#After_effects|after effects]] that occur during the drug's [[duration|come down]] period, including [[anxiety]], [[depression]], and [[cognitive fatigue]].<ref>http://www.sciencedirect.com/science/article/pii/S0306452207006732 | Wang, X.; Baumann, M. H.; Dersch, C. M.; Rothman, R. B. (2007-08-10). "Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of l-5-hydroxytryptophan". Neuroscience. 148 (1): 212–220. doi:10.1016/j.neuroscience.2007.05.024. PMID 17629409.</ref> Since 5-HTP is a precursor for the neurotransmitter [[serotonin]] and MDMA depletes serotonin levels in the brain, it is believed that taking 5-HTP after coming down will speed the production of serotonin. 5-HTP should not be taken until 12 hours after the MDMA was last dosed because combining the two drugs could result in a potentially life-threatening condition called [[serotonin syndrome]].
+==Toxicity and harm potential==
+Due to the conversion of 5-HTP into serotonin by the liver, there may be a significant risk of heart valve disease from serotonin's effect on the heart.[15][16]
+It has been suggested that 5-HTP may cause eosinophilia-myalgia syndrome (EMS), a serious condition which results in extreme muscle tenderness, myalgia, and blood abnormalities. However, there is evidence to show that EMS was likely caused by a contaminant in certain 5-HTP supplements.[17]
+===Dangerous interactions===
+When combined with antidepressants of the MAOI or SSRI class, high doses of 5-HTP can cause acute serotonin syndrome in rats.[8][9] In humans, 5-HTP has never been clinically associated with serotonin syndrome, although 5-HTP can precipitate mania when added to a MAOI.[10]
 ==See also==
 *[[Serotonin syndrome]]