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In comparison to the effects of other nootropics such as [[noopept]], this compound can be described as conferring both physical stimulation and cognitive stimulation.
In comparison to the effects of other nootropics such as [[noopept]], this compound can be described as conferring both physical stimulation and cognitive stimulation.
====Sensory effects====
*'''[[Effect::Bodily control enhancement]]''' - In addition to raising energy levels, SAM-e shows efficacy in improving joint mobility in those with osteoarthritis.<ref>[Meta-analysis of the efficacy of adenosylmethionine and oxaceprol in the treatment of osteoarthritis]. | http://www.ncbi.nlm.nih.gov/pubmed/12436324</ref>
*'''[[Effect::Appetite suppression]]'''
*'''[[Effect::Stamina enhancement]]'''
*'''[[Effect::Tactile enhancement]]'''


====Physical effects====
====Physical effects====
*'''[[Effect::Appetite suppression]]'''
*'''[[Effect::Bodily control enhancement]]''' - In addition to raising energy levels, SAM-e shows efficacy in improving joint mobility in those with osteoarthritis.<ref>[Meta-analysis of the efficacy of adenosylmethionine and oxaceprol in the treatment of osteoarthritis]. | http://www.ncbi.nlm.nih.gov/pubmed/12436324</ref>
*'''[[Effect::Dehydration]]'''
*'''[[Effect::Diarrhea]]'''
*'''[[Effect::Headaches]]'''
*'''[[Effect::Muscle spasms]]'''
*'''[[Effect::Pain relief]]''' - Appears to be about as effective as NSAIDS such as [[ibuprofen]] for joint inflammation and pain.<ref> Italian double-blind multicenter study comparing S-adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint disease. | http://www.ncbi.nlm.nih.gov/pubmed/3318442</ref>
*'''[[Effect::Pain relief]]''' - Appears to be about as effective as NSAIDS such as [[ibuprofen]] for joint inflammation and pain.<ref> Italian double-blind multicenter study comparing S-adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint disease. | http://www.ncbi.nlm.nih.gov/pubmed/3318442</ref>
*'''[[Effect::Stamina enhancement]]'''
*'''[[Effect::Stimulation]]''' - The stimulation which Sam-e presents can be considered as subtle, yet persistent and energetic comparable to that of [[caffeine]], yet even less forced in nature.
*'''[[Effect::Stimulation]]''' - The stimulation which Sam-e presents can be considered as subtle, yet persistent and energetic comparable to that of [[caffeine]], yet even less forced in nature.
*'''[[Effect::Headaches]]'''
*'''[[Effect::Muscle spasms]]'''
*'''[[Effect::Stomach cramps]]'''
*'''[[Effect::Stomach cramps]]'''
*'''[[Effect::Dehydration]]'''
*'''[[Effect::Tactile enhancement]]'''
*'''[[Effect::Diarrhea]]'''


====Cognitive effect====
====Cognitive effect====
 
*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Anxiety suppression]]'''
*'''[[Effect::Cognitive euphoria]]'''
*'''[[Effect::Focus enhancement]]'''
*'''[[Effect::Irritability]]'''
*'''[[Effect::Mania]]'''<ref>A Case Report of a Manic Episode Triggered by S-Adenosylmethionine (SAMe) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC315487/</ref>
*'''[[Effect::Mania]]'''<ref>A Case Report of a Manic Episode Triggered by S-Adenosylmethionine (SAMe) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC315487/</ref>
*'''[[Effect::Cognitive euphoria]]'''
*'''[[Effect::Memory enhancement]]'''
*'''[[Effect::Wakefulness]]'''
*'''[[Effect::Mindfulness]]'''
*'''[[Effect::Motivation enhancement]]'''
*'''[[Effect::Rejuvenation]]'''
*'''[[Effect::Rejuvenation]]'''
*'''[[Effect::Anxiety suppression]]'''
*'''[[Effect::Thought connectivity]]'''
*'''[[Effect::Thought connectivity]]'''
*'''[[Effect::Thought organization]]'''
*'''[[Effect::Thought organization]]'''
*'''[[Effect::Focus enhancement]]'''
*'''[[Effect::Wakefulness]]'''
*'''[[Effect::Mindfulness]]'''
 
*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Motivation enhancement]]'''
*'''[[Effect::Memory enhancement]]'''
*'''[[Effect::Irritability]]'''
==Toxicity and harm potential==
==Toxicity and harm potential==
There are no clinically significant side-effects of Sam-e supplementation acutely. Although side-effects are not commonly reported with SAMe, numerous studies note a small set of participants who experience [[mania]] after supplementing SAMe. It is not common, but it does appear to be related to SAMe supplementation for unknown reasons; it has been reported in some persons without history of mania as well and does not appear to be related to any pathological condition per se.<ref> S-adenosylmethionine (SAM-e) for the treatment of depression in people living with HIV/AIDS | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535560/</ref><ref> Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence. | http://www.ncbi.nlm.nih.gov/pubmed/12420702</ref>
There are no clinically significant side-effects of Sam-e supplementation acutely. Although side-effects are not commonly reported with SAMe, numerous studies note a small set of participants who experience [[mania]] after supplementing SAMe. It is not common, but it does appear to be related to SAMe supplementation for unknown reasons; it has been reported in some persons without history of mania as well and does not appear to be related to any pathological condition per se.<ref> S-adenosylmethionine (SAM-e) for the treatment of depression in people living with HIV/AIDS | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535560/</ref><ref> Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence. | http://www.ncbi.nlm.nih.gov/pubmed/12420702</ref>
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