2C-B: Difference between revisions

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~~'''~~2C-B~~''' (4-bromo-~~2,5-~~dimethoxyphenethylamine)~~ is a psychedelic ~~[[Phenethylamines|phenethylamine]]~~ of the [[2C~~-x]]~~ family~~; it~~ was first synthesized by [[Alexander Shulgin]].

2C-B or 2,5-dimethoxy-4-bromophenethylamine is a psychedelic drug of the 2C family. It was first synthesized by Alexander Shulgin in 1974. In Shulgin's book PiHKAL, the dosage range is listed as 16–24 mg. 2C-B is sold as a white powder sometimes pressed in tablets or gel caps and is referred to on the street as 'Rusko', 'Spectrum', 'Venus', 'B's', 'CB's', or 'Nexus'.[1] The drug is usually taken orally, but can also be insufflated or vaporized.

~~2C-B is a psychedelic known~~ for its ~~powerful entactogenic~~ effects and ~~bright visuals~~. ~~Many reports suggest that while~~ 2C-B~~'s entactogenic effects are less pronounced than MDMA~~, the ~~psychedelic effects are more pronounced and~~ the ~~stimulation is much less pronounced~~.

It first saw use among the psychiatric community as an aid during therapy. It was considered one of the best drugs for this purpose because of its short duration, relative absence of side effects, and comparably mild nature.<ref>Erowid 2-CB effects | http://www.erowid.org/chemicals/2cb/2cb_effects.shtml</ref> Shortly after becoming popular in the medical community, it became popular recreationally. 2C-B was first sold commercially as an aphrodisiac[3] under the trade name "Eros", which was manufactured by the German pharmaceutical company Drittewelle.[4] For several years, it was available as tablets in Dutch smart shops under the name "Nexus".

==Chemistry==

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==Pharmacology==

Unlike most hallucinogens, 2C-B has been shown to be a low efficacy serotonin 5-HT2A receptor [[Agonist#Agonists|partial agonist]] or even full [[antagonist]]. This suggests that the 5-HT2C receptor is primarily responsible for mediating the effects experienced by users of 2C-B. <ref>http://jpet.aspetjournals.org/content/321/3/1054.full.pdf</ref>

Unlike most hallucinogens, 2C-B has been shown to be a low efficacy serotonin 5-HT2A receptor [[Agonist#Agonists|partial agonist]]<ref>Functional Selectivity of Hallucinogenic Phenethylamine and Phenylisopropylamine Derivatives at Human 5-Hydroxytryptamine (5-HT)2A and 5-HT2C Receptors | http://jpet.aspetjournals.org/content/321/3/1054</ref> or even full [[antagonist]].<ref>http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0705722/abstract;jsessionid=7F4731B4EF0AF36C37D0E3CA60319C4E.f03t04 | http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0705722/abstract;jsessionid=7F4731B4EF0AF36C37D0E3CA60319C4E.f03t04</ref> This suggests that the 5-HT2C receptor is primarily responsible for mediating the effects experienced by users of 2C-B. <ref>http://jpet.aspetjournals.org/content/321/3/1054.full.pdf</ref>

=Subjective effects=

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-'''2C-B''' (4-bromo-2,5-dimethoxyphenethylamine) is a psychedelic [[Phenethylamines|phenethylamine]] of the [[2C-x]] family; it was first synthesized by [[Alexander Shulgin]].
+C-B or 2,5-dimethoxy-4-bromophenethylamine is a psychedelic drug of the 2C family. It was first synthesized by Alexander Shulgin in 1974. In Shulgin's book PiHKAL, the dosage range is listed as 16–24 mg. 2C-B is sold as a white powder sometimes pressed in tablets or gel caps and is referred to on the street as 'Rusko', 'Spectrum', 'Venus', 'B's', 'CB's', or 'Nexus'.[1] The drug is usually taken orally, but can also be insufflated or vaporized.
-C-B is a psychedelic known for its powerful entactogenic effects and bright visuals. Many reports suggest that while 2C-B's entactogenic effects are less pronounced than MDMA, the psychedelic effects are more pronounced and the stimulation is much less pronounced.
+It first saw use among the psychiatric community as an aid during therapy. It was considered one of the best drugs for this purpose because of its short duration, relative absence of side effects, and comparably mild nature.<ref>Erowid 2-CB effects | http://www.erowid.org/chemicals/2cb/2cb_effects.shtml</ref> Shortly after becoming popular in the medical community, it became popular recreationally. 2C-B was first sold commercially as an aphrodisiac[3] under the trade name "Eros", which was manufactured by the German pharmaceutical company Drittewelle.[4] For several years, it was available as tablets in Dutch smart shops under the name "Nexus".
 ==Chemistry==
@@ Line 67: / Line 67: @@
 ==Pharmacology==
-Unlike most hallucinogens, 2C-B has been shown to be a low efficacy serotonin 5-HT<sub>2A</sub> receptor [[Agonist#Agonists|partial agonist]] or even full [[antagonist]]. This suggests that the 5-HT<sub>2C</sub> receptor is primarily responsible for mediating the effects experienced by users of 2C-B. <ref>http://jpet.aspetjournals.org/content/321/3/1054.full.pdf</ref>
+Unlike most hallucinogens, 2C-B has been shown to be a low efficacy serotonin 5-HT<sub>2A</sub> receptor [[Agonist#Agonists|partial agonist]]<ref>Functional Selectivity of Hallucinogenic Phenethylamine and Phenylisopropylamine Derivatives at Human 5-Hydroxytryptamine (5-HT)2A and 5-HT2C Receptors | http://jpet.aspetjournals.org/content/321/3/1054</ref> or even full [[antagonist]].<ref>http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0705722/abstract;jsessionid=7F4731B4EF0AF36C37D0E3CA60319C4E.f03t04 | http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0705722/abstract;jsessionid=7F4731B4EF0AF36C37D0E3CA60319C4E.f03t04</ref> This suggests that the 5-HT<sub>2C</sub> receptor is primarily responsible for mediating the effects experienced by users of 2C-B. <ref>http://jpet.aspetjournals.org/content/321/3/1054.full.pdf</ref>
 =Subjective effects=