Sleep-wake cycle: Difference between revisions

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*The falling levels of adenosine enable the cholinergic neurons in the basal forebrain to become uninhibited to activation <ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016451/#S13title | HISTAMINE IN THE REGULATION OF WAKEFULNESS</ref><ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362278/ | Adenosine inhibits glutamatergic input to basal forebrain cholinergic neurons</ref>

*As adenosine is metabolized and it's levels decrease it no longer leads to the inhibition of histamine, ~~enabling one~~ to ~~become vigilant and awaken~~.<ref>http://www.ncbi.nlm.nih.gov/pubmed/21401496 | The role of adenosine in the regulation of sleep.</ref><ref>http://www.ncbi.nlm.nih.gov/pubmed/15748171 | An adenosine A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats.</ref>

*As adenosine is metabolized and it's levels decrease it no longer leads to the [[GABAergic]] inhibition of histamine, allowing vigilance to increase.<ref>http://www.ncbi.nlm.nih.gov/pubmed/21401496 | The role of adenosine in the regulation of sleep.</ref><ref>http://www.ncbi.nlm.nih.gov/pubmed/15748171 | An adenosine A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats.</ref>

*As these elements of wakefulness begin to return [[REM cycles]] and brief awakenings occur with increasing density, eventually resulting in a full awakening.

==See also==

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 *The falling levels of adenosine enable the cholinergic neurons in the basal forebrain to become uninhibited to activation <ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016451/#S13title | HISTAMINE IN THE REGULATION OF WAKEFULNESS</ref><ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362278/ | Adenosine inhibits glutamatergic input to basal forebrain cholinergic neurons</ref>
-*As adenosine is metabolized and it's levels decrease it no longer leads to the inhibition of histamine, enabling one to become vigilant and awaken.<ref>http://www.ncbi.nlm.nih.gov/pubmed/21401496 | The role of adenosine in the regulation of sleep.</ref><ref>http://www.ncbi.nlm.nih.gov/pubmed/15748171 | An adenosine A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats.</ref>
+*As adenosine is metabolized and it's levels decrease it no longer leads to the [[GABAergic]] inhibition of histamine, allowing vigilance to increase.<ref>http://www.ncbi.nlm.nih.gov/pubmed/21401496 | The role of adenosine in the regulation of sleep.</ref><ref>http://www.ncbi.nlm.nih.gov/pubmed/15748171 | An adenosine A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats.</ref>
+*As these elements of wakefulness begin to return [[REM cycles]] and brief awakenings occur with increasing density, eventually resulting in a full awakening.
 ==See also==