Talk:W-18: Difference between revisions

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~~Recent information suggests that W-18:~~

A street drug feared to be stronger than any opioid known to science turns out not be an opioid at all. W-18, an experimental pain medicine first developed at the University of Alberta in Edmonton in the 1980s, doesn’t even appear to provide relief in animal pain models.

The findings appeared July 24, 2016 in a preprint report (PDF) in bioRxiv (pronounced “Bioarchive”), a non-peer-reviewed resource of Cold Spring Harbor Laboratories designed to rapidly disseminate critical research findings. The authors include scientists from the National Institute of Drug Abuse, the University of North Carolina at Chapel Hill, Memorial Sloan Kettering Cancer Center and the Scripps Research Institute.

The comprehensive study not only showed the lack of opioid effects of W-18 or a related chemical called W-15. They showed that human or mouse metabolites of the chemicals had no effect on human or mouse opioid receptors. More surprisingly, a receptorome-wide screen showed no substantial effect of the compounds or metabolites on any psychoactive drug receptor. The study marks a rare case where a potentially lethal drug of abuse is likely to be far less of a public health risk than originally believed.

~~<ref>http://www.forbes.com/sites/davidkroll/2016/07/28/w-18-is-not-a-super-potent-designer-opioid-as-originally-believed/#17de6fe44121</ref>~~

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'''W-18''', or '''1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide''', is an extremely potent [[psychoactive class::opioid]] [[pain relief|analgesic]] with little to no history of human use. This compound is claimed to be 10,000x more potent than [[morphine]] and 1000x more potent than [[fentanyl]].<ref>Everything We Know So Far About W-18, the Drug That’s 10,000 Times More Powerful Than Morphine (Vice) | http://www.vice.com/read/everything-we-know-so-far-about-w-18-the-drug-thats-100-times-more-powerful-than-fentanyl</ref>

Although commonly reported as an opioid in the popular press, it is not known how the drug works as its distinctive structure differs somewhat to known opioid drugs.<ref>W-18, The High-Potency Research Chemical Making News: What It Is And What It Isn't (Forbes) | http://www.forbes.com/sites/davidkroll/2016/04/30/w-18-the-high-potency-research-chemical-making-news-what-it-is-and-what-it-isnt/#68634ec42354</ref> It was invented at the University of Alberta<ref>Street drug W-18 is highly lethal, and still legal (CBC News) | http://www.cbc.ca/news/canada/edmonton/street-drug-w-18-is-highly-lethal-and-still-legal-1.3546094</ref> by the chemists Edward Knaus, Brent Warren and Theodore Ondrus in 1981.<ref>"Patent US 4468403 - Analgesic substituted piperidylidene-2-sulfon(cyan)amide derivatives" | https://www.lens.org/images/patent/US/4468403/A/US_4468403_A.pdf</ref><ref>http://www.google.co.ve/patents/CA1255680A1?cl=en</ref>

Recent information suggests that W-18, a street drug feared to be stronger than any opioid known to science turns out not be an opioid at all. W-18, an experimental pain medicine first developed at the University of Alberta in Edmonton in the 1980s, doesn’t even appear to provide relief in animal pain models. These findings appeared July 24, 2016 in a preprint report (PDF) in bioRxiv (pronounced “Bioarchive”), a non-peer-reviewed resource of Cold Spring Harbor Laboratories designed to rapidly disseminate critical research findings.

The comprehensive study not only showed the lack of opioid effects of W-18 or a related chemical called W-15. They showed that human or mouse metabolites of the chemicals had no effect on human or mouse opioid receptors. More surprisingly, a receptorome-wide screen showed no substantial effect of the compounds or metabolites on any psychoactive drug receptor. The study marks a rare case where a potentially lethal drug of abuse is likely to be far less of a public health risk than originally believed.<ref>http://www.forbes.com/sites/davidkroll/2016/07/28/w-18-is-not-a-super-potent-designer-opioid-as-originally-believed/#17de6fe44121</ref>

The compound's toxicity is not fully characterized, but its potency gives it potential for fatal abuse.

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-Recent information suggests that W-18:
-A street drug feared to be stronger than any opioid known to science turns out not be an opioid at all. W-18, an experimental pain medicine first developed at the University of Alberta in Edmonton in the 1980s, doesn’t even appear to provide relief in animal pain models.
-The findings appeared July 24, 2016 in a preprint report (PDF) in bioRxiv (pronounced “Bioarchive”), a non-peer-reviewed resource of Cold Spring Harbor Laboratories designed to rapidly disseminate critical research findings. The authors include scientists from the National Institute of Drug Abuse, the University of North Carolina at Chapel Hill, Memorial Sloan Kettering Cancer Center and the Scripps Research Institute.
-The comprehensive study not only showed the lack of opioid effects of W-18 or a related chemical called W-15. They showed that human or mouse metabolites of the chemicals had no effect on human or mouse opioid receptors. More surprisingly, a receptorome-wide screen showed no substantial effect of the compounds or metabolites on any psychoactive drug receptor. The study marks a rare case where a potentially lethal drug of abuse is likely to be far less of a public health risk than originally believed.
-<ref>http://www.forbes.com/sites/davidkroll/2016/07/28/w-18-is-not-a-super-potent-designer-opioid-as-originally-believed/#17de6fe44121</ref>
 {{Warning/W-18}}
 {{SubstanceBox/W-18}}
@@ Line 16: / Line 8: @@
 '''W-18''', or '''1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide''', is an extremely potent [[psychoactive class::opioid]] [[pain relief|analgesic]] with little to no history of human use. This compound is claimed to be 10,000x more potent than [[morphine]] and 1000x more potent than [[fentanyl]].<ref>Everything We Know So Far About W-18, the Drug That’s 10,000 Times More Powerful Than Morphine (Vice) | http://www.vice.com/read/everything-we-know-so-far-about-w-18-the-drug-thats-100-times-more-powerful-than-fentanyl</ref>
 Although commonly reported as an opioid in the popular press, it is not known how the drug works as its distinctive structure differs somewhat to known opioid drugs.<ref>W-18, The High-Potency Research Chemical Making News: What It Is And What It Isn't (Forbes) | http://www.forbes.com/sites/davidkroll/2016/04/30/w-18-the-high-potency-research-chemical-making-news-what-it-is-and-what-it-isnt/#68634ec42354</ref> It was invented at the University of Alberta<ref>Street drug W-18 is highly lethal, and still legal (CBC News) | http://www.cbc.ca/news/canada/edmonton/street-drug-w-18-is-highly-lethal-and-still-legal-1.3546094</ref> by the chemists Edward Knaus, Brent Warren and Theodore Ondrus in 1981.<ref>"Patent US 4468403 - Analgesic substituted piperidylidene-2-sulfon(cyan)amide derivatives" | https://www.lens.org/images/patent/US/4468403/A/US_4468403_A.pdf</ref><ref>http://www.google.co.ve/patents/CA1255680A1?cl=en</ref>
+Recent information suggests that W-18, a street drug feared to be stronger than any opioid known to science turns out not be an opioid at all. W-18, an experimental pain medicine first developed at the University of Alberta in Edmonton in the 1980s, doesn’t even appear to provide relief in animal pain models. These findings appeared July 24, 2016 in a preprint report (PDF) in bioRxiv (pronounced “Bioarchive”), a non-peer-reviewed resource of Cold Spring Harbor Laboratories designed to rapidly disseminate critical research findings.
+The comprehensive study not only showed the lack of opioid effects of W-18 or a related chemical called W-15. They showed that human or mouse metabolites of the chemicals had no effect on human or mouse opioid receptors. More surprisingly, a receptorome-wide screen showed no substantial effect of the compounds or metabolites on any psychoactive drug receptor. The study marks a rare case where a potentially lethal drug of abuse is likely to be far less of a public health risk than originally believed.<ref>http://www.forbes.com/sites/davidkroll/2016/07/28/w-18-is-not-a-super-potent-designer-opioid-as-originally-believed/#17de6fe44121</ref>
 The compound's toxicity is not fully characterized, but its potency gives it potential for fatal abuse.