Modafinil: Difference between revisions

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==Pharmacology==

Research suggests that modafinil increases hypothalamic histamine levels in the brains of rats, which may contribute to its locomotor effects.<ref>European Journal of Pharmacology - Involvement of central histaminergic systems in modafinil-induced but not methylphenidate-induced increases in locomotor activity in rats | http://www.sciencedirect.com/science/article/pii/S001429990701031X</ref> Modafinil has recently been shown to act as a [[reuptake inhibitor]] for the [[neurotransmitter]] [[dopamine]], evidently leading to increased extraceullular concentrations of dopamine and dopaminergic neurotransmission.<ref>The Journal of Pharmacology and Experimental Therapeutics - Evidence for the Involvement of Dopamine Transporters in Behavioral Stimulant Effects of Modafinil (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672878</ref> This essentially allows dopamine to accumulate and be reused, causing physically stimulating and motivating effects.

Research suggests that modafinil increases hypothalamic histamine levels in the brains of rats, which may contribute to its locomotor effects.<ref>European Journal of Pharmacology - Involvement of central histaminergic systems in modafinil-induced but not methylphenidate-induced increases in locomotor activity in rats (ScienceDirect) | http://www.sciencedirect.com/science/article/pii/S001429990701031X</ref> Modafinil has recently been shown to act as a [[reuptake inhibitor]] for the [[neurotransmitter]] [[dopamine]], evidently leading to increased extraceullular concentrations of dopamine and dopaminergic neurotransmission.<ref>The Journal of Pharmacology and Experimental Therapeutics - Evidence for the Involvement of Dopamine Transporters in Behavioral Stimulant Effects of Modafinil (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672878</ref> This essentially allows dopamine to accumulate and be reused, causing physically stimulating and motivating effects.

==Subjective effects==

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 ==Pharmacology==
-Research suggests that modafinil increases hypothalamic histamine levels in the brains of rats, which may contribute to its locomotor effects.<ref>European Journal of Pharmacology - Involvement of central histaminergic systems in modafinil-induced but not methylphenidate-induced increases in locomotor activity in rats | http://www.sciencedirect.com/science/article/pii/S001429990701031X</ref> Modafinil has recently been shown to act as a [[reuptake inhibitor]] for the [[neurotransmitter]] [[dopamine]], evidently leading to increased extraceullular concentrations of dopamine and dopaminergic neurotransmission.<ref>The Journal of Pharmacology and Experimental Therapeutics - Evidence for the Involvement of Dopamine Transporters in Behavioral Stimulant Effects of Modafinil (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672878</ref> This essentially allows dopamine to accumulate and be reused, causing physically stimulating and motivating effects.
+Research suggests that modafinil increases hypothalamic histamine levels in the brains of rats, which may contribute to its locomotor effects.<ref>European Journal of Pharmacology - Involvement of central histaminergic systems in modafinil-induced but not methylphenidate-induced increases in locomotor activity in rats (ScienceDirect) | http://www.sciencedirect.com/science/article/pii/S001429990701031X</ref> Modafinil has recently been shown to act as a [[reuptake inhibitor]] for the [[neurotransmitter]] [[dopamine]], evidently leading to increased extraceullular concentrations of dopamine and dopaminergic neurotransmission.<ref>The Journal of Pharmacology and Experimental Therapeutics - Evidence for the Involvement of Dopamine Transporters in Behavioral Stimulant Effects of Modafinil (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672878</ref> This essentially allows dopamine to accumulate and be reused, causing physically stimulating and motivating effects.
 ==Subjective effects==