Releasing agent: Difference between revisions

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==Selectivity==

Releasing agents act to varying extents on the monoamine neurotransmitters. Some will induce the release of all three monoamines; an example of this is [[MDMA]]. Others are more selective as [[methamphetamine]] is a potent releasing agent of dopamine and noradrenaline, but is a weak releaser of serotonin. A majority of releasing agents are non-selective, but there are currently a limited amount of agents that release serotonin (SRAs) or norephinephrine (NRAs) selectively; no selective dopamine releasing agents are currently known. Many tryptamines, such as [[DMT]], [[DiPT]], and [[psilocin]], are selective serotonin releasing agents in addition to their other pharmacological effects.

Releasing agents act to varying extents on the monoamine neurotransmitters. Some will induce the release of all three monoamines; an example of this is [[MDMA]]. Others are more selective as [[methamphetamine]] is a potent releasing agent of dopamine and noradrenaline, but is a weak releaser of serotonin. A majority of releasing agents are non-selective, but there are currently a limited amount of agents that release serotonin (SRAs) or norephinephrine (NRAs) selectively; no selective dopamine releasing agents are currently known. Many tryptamines, such as [[DMT]], [[DiPT]], and [[psilocin]], are selective serotonin releasing agents in addition to their other pharmacological effects.<ref>Blough BE, Landavazo A, Decker AM, Partilla JS, Baumann MH, Rothman RB (October 2014). "Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes". Psychopharmacology 231 (21): 4135–44. | https://www.ncbi.nlm.nih.gov/pubmed/24800892</ref>

==Neurotoxicity==

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 ==Selectivity==
-Releasing agents act to varying extents on the monoamine neurotransmitters. Some will induce the release of all three monoamines; an example of this is [[MDMA]]. Others are more selective as [[methamphetamine]] is a potent releasing agent of dopamine and noradrenaline, but is a weak releaser of serotonin. A majority of releasing agents are non-selective, but there are currently a limited amount of agents that release serotonin (SRAs) or norephinephrine (NRAs) selectively; no selective dopamine releasing agents are currently known. Many tryptamines, such as [[DMT]], [[DiPT]], and [[psilocin]], are selective serotonin releasing agents in addition to their other pharmacological effects.
+Releasing agents act to varying extents on the monoamine neurotransmitters. Some will induce the release of all three monoamines; an example of this is [[MDMA]]. Others are more selective as [[methamphetamine]] is a potent releasing agent of dopamine and noradrenaline, but is a weak releaser of serotonin. A majority of releasing agents are non-selective, but there are currently a limited amount of agents that release serotonin (SRAs) or norephinephrine (NRAs) selectively; no selective dopamine releasing agents are currently known. Many tryptamines, such as [[DMT]], [[DiPT]], and [[psilocin]], are selective serotonin releasing agents in addition to their other pharmacological effects.<ref>Blough BE, Landavazo A, Decker AM, Partilla JS, Baumann MH, Rothman RB (October 2014). "Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes". Psychopharmacology 231 (21): 4135–44. | https://www.ncbi.nlm.nih.gov/pubmed/24800892</ref>
 ==Neurotoxicity==