4F-MPH: Difference between revisions

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| ''[[4F-MPH/Summary|Summary sheet: 4F-MPH]]''

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'''4F-MPH''' ('''4'-fluoro-methylphenidate''') is a [[stimulant]], [[substituted phenethylamine]], [[piperidine]], and close analog of [[methylphenidate]] (ritalin). The two substances have very similar pharmacological mechanisms but distinctively different subjective effects as 4F-MPH can be considered significantly more euphoric and recreational in its experience. It also acts as a higher efficiency dopamine reuptake inhibitor than the closely related methylphenidate.<ref>Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/8632426</ref><ref>Biochemical and behavioral characterization of novel methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/11961053</ref><ref>Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites | https://www.ncbi.nlm.nih.gov/pubmed/15026075</ref><ref>Quantitative structure-activity relationship studies of threo-methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/20846865</ref><ref>Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists | http://pubs.acs.org/doi/abs/10.1021/cr9700538</ref>

'''4F-MPH''' ('''4'-fluoro-methylphenidate''') is a [[stimulant]], [[substituted phenethylamine]], [[piperidine]], and close analog of [[methylphenidate]] (ritalin). The two substances have very similar pharmacological mechanisms but distinctively different subjective effects as 4F-MPH can be considered significantly more euphoric and recreational in its experience. It also acts as a higher efficiency dopamine reuptake inhibitor than the closely related methylphenidate.<ref>Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/8632426</ref><ref>Biochemical and behavioral characterization of novel methylphenidate analogs (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/11961053</ref><ref>Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/15026075</ref><ref>Quantitative structure-activity relationship studies of threo-methylphenidate analogs (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/20846865</ref><ref>Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists | http://pubs.acs.org/doi/abs/10.1021/cr9700538</ref>

4F-MPH has little to no history of human usage prior to its distribution online through [[research chemical]] vendors. It was initially developed as a replacement for [[ethylphenidate]] which became illegal in the United Kingdom on April 10, 2015 due to a temporary blanket ban. Anecdotal reports suggest that it is considerably more potent with fewer uncomfortable side effects such as [[anxiety]], [[muscle spasms]] and [[compulsive redosing]].<ref>http://www.bluelight.org/vb/threads/770658-4-Fluoromethylphenidate-(4F-MPH)</ref>

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 | ''[[4F-MPH/Summary|Summary sheet: 4F-MPH]]''
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-'''4F-MPH''' ('''4'-fluoro-methylphenidate''') is a [[stimulant]], [[substituted phenethylamine]], [[piperidine]], and close analog of [[methylphenidate]] (ritalin). The two substances have very similar pharmacological mechanisms but distinctively different subjective effects as 4F-MPH can be considered significantly more euphoric and recreational in its experience. It also acts as a higher efficiency dopamine reuptake inhibitor than the closely related methylphenidate.<ref>Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/8632426</ref><ref>Biochemical and behavioral characterization of novel methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/11961053</ref><ref>Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites | https://www.ncbi.nlm.nih.gov/pubmed/15026075</ref><ref>Quantitative structure-activity relationship studies of threo-methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/20846865</ref><ref>Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists | http://pubs.acs.org/doi/abs/10.1021/cr9700538</ref>
+'''4F-MPH''' ('''4'-fluoro-methylphenidate''') is a [[stimulant]], [[substituted phenethylamine]], [[piperidine]], and close analog of [[methylphenidate]] (ritalin). The two substances have very similar pharmacological mechanisms but distinctively different subjective effects as 4F-MPH can be considered significantly more euphoric and recreational in its experience. It also acts as a higher efficiency dopamine reuptake inhibitor than the closely related methylphenidate.<ref>Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/8632426</ref><ref>Biochemical and behavioral characterization of novel methylphenidate analogs (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/11961053</ref><ref>Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/15026075</ref><ref>Quantitative structure-activity relationship studies of threo-methylphenidate analogs (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/20846865</ref><ref>Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists | http://pubs.acs.org/doi/abs/10.1021/cr9700538</ref>
 F-MPH has little to no history of human usage prior to its distribution online through [[research chemical]] vendors. It was initially developed as a replacement for [[ethylphenidate]] which became illegal in the United Kingdom on April 10, 2015 due to a temporary blanket ban. Anecdotal reports suggest that it is considerably more potent with fewer uncomfortable side effects such as [[anxiety]], [[muscle spasms]] and [[compulsive redosing]].<ref>http://www.bluelight.org/vb/threads/770658-4-Fluoromethylphenidate-(4F-MPH)</ref>