Volumetric liquid dosing: Difference between revisions

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There is a volumetric dosing calculator located [http://volume.tripsit.me/ here] which will calculate the amount of drug and solvent needed as well as the concentration.

==Materials==

*Solvent such as alcohol (vodka or everclear work best), water, propylene glycol, or glycerine depending on substance

**(Note: [http://www.google.com Search the internet] to determine what solvent to use. All drugs should dissolve in alcohol, but many drugs will not dissolve in water.)

*Oral syringe, graduated cylinder, or eyedropper

*[[Dosage#Milligram scales|Milligram scale]]

==Solvent==

Certain psychoactive substances (particularly benzodiazepines) are practically insoluble in water, but will dissolve at various concentrations in other easy to acquire solvents. These include:

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The first important consideration is the maximum concentration at which your chosen solvent will dissolve your product. A value can usually be found with minimal effort on the internet, using a search term like "''<material> <solvent> solubility''".

Beneficially, ethanol is ~~miscible~~ with most solvents. Just a few drops is usually enough to increase the maximum concentration dramatically, even when using water as the major component.

Beneficially, ethanol is mixable with most solvents. Just a few drops is usually enough to increase the maximum concentration dramatically, even when using water as the major component.

==Measurement==

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===Powder===

~~Preferably a fresh batch of known weight would be used, but it's best~~ to weigh the ~~entirety~~ of the ~~material before dissolution~~, so you ~~can calculate the necessary volume~~ of ~~solvent required~~ to ~~achieve~~ the ~~desired concentration~~.

It is vital to weigh the amount of powder that you want to volumetrically dose with a [[Dosage#Milligram scale|milligram scale]]first. Even if the weight is on the bag itself, do not assume that the vendor has given you a certain amount of a substance; it is not uncommon for vendors to give more product than is labelled. If one believes they received 500mg, but actually received 1000mg, then the liquid solution will be twice as strong as expected.

~~For example; to~~ achieve 10mg/1ml, measure the weight of material in milligrams, then divide the value by 10. So for 1000mg material, 100ml of solvent will be required.

To achieve a concentration of 10mg/1ml, measure the weight of material in milligrams, then divide the value by 10. So for 1000mg material, 100ml of solvent will be required. It is safest to use the lowest concentration possible, preferably 1mg/1mL or less for very potent drugs active in the 1mg range.

==Dissolution==

@@ Line 9: / Line 9: @@
 There is a volumetric dosing calculator located [http://volume.tripsit.me/ here] which will calculate the amount of drug and solvent needed as well as the concentration.
+==Materials==
+*Solvent such as alcohol (vodka or everclear work best), water, propylene glycol, or glycerine depending on substance
+**(Note: [http://www.google.com Search the internet] to determine what solvent to use. All drugs should dissolve in alcohol, but many drugs will not dissolve in water.)
+*Oral syringe, graduated cylinder, or eyedropper
+*[[Dosage#Milligram scales|Milligram scale]]
 ==Solvent==
 Certain psychoactive substances (particularly benzodiazepines) are practically insoluble in water, but will dissolve at various concentrations in other easy to acquire solvents. These include:
@@ Line 18: / Line 24: @@
 The first important consideration is the maximum concentration at which your chosen solvent will dissolve your product. A value can usually be found with minimal effort on the internet, using a search term like "''<material> <solvent> solubility''".
-Beneficially, ethanol is miscible with most solvents. Just a few drops is usually enough to increase the maximum concentration dramatically, even when using water as the major component.
+Beneficially, ethanol is mixable with most solvents. Just a few drops is usually enough to increase the maximum concentration dramatically, even when using water as the major component.
 ==Measurement==
@@ Line 27: / Line 33: @@
 ===Powder===
-Preferably a fresh batch of known weight would be used, but it's best to weigh the entirety of the material before dissolution, so you can calculate the necessary volume of solvent required to achieve the desired concentration.
+It is vital to weigh the amount of powder that you want to volumetrically dose with a [[Dosage#Milligram scale|milligram scale]]first. Even if the weight is on the bag itself, do not assume that the vendor has given you a certain amount of a substance; it is not uncommon for vendors to give more product than is labelled. If one believes they received 500mg, but actually received 1000mg, then the liquid solution will be twice as strong as expected.
-For example; to achieve 10mg/1ml, measure the weight of material in milligrams, then divide the value by 10. So for 1000mg material, 100ml of solvent will be required.
+To achieve a concentration of 10mg/1ml, measure the weight of material in milligrams, then divide the value by 10. So for 1000mg material, 100ml of solvent will be required. It is safest to use the lowest concentration possible, preferably 1mg/1mL or less for very potent drugs active in the 1mg range.
 ==Dissolution==