Volumetric liquid dosing: Difference between revisions

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Volumetric dosing is the process of dissolving a compound in a liquid to make it easier to measure. In the interest of harm reduction, it is essential to prepare certain compounds which are too potent to measure with traditional weighing scales within a liquid solution.

<div style="border: 1px solid #b75; background: #fef7f5; padding: 1em; margin-bottom: 1em; padding: 1em .5em;">[[File:Attention_niels_epting.svg|frameless|link=|25px]] It is probably best to avoid carrying out this procedure while already under the influence of amnesic sedatives.

Many psychoactive substances, including [[benzodiazepines]] and certain [[psychedelics]], are active at less than a single milligram. Such small quantities cannot be accurately measured with common digital scales, so the drug must instead be dosed volumetrically by weighing out larger amounts the compound and dissolving it in a calculated volume of a suitable liquid.

~~</div>~~

~~In the interest of harm reduction, it is essential to prepare solutions from [[benzodiazepine]] powders.~~

Many ~~benzodiazepines~~, including [[~~alprazolam~~]] and [[~~etizolam~~]], are active at less than a single milligram. Such small quantities cannot be accurately measured with common digital scales, so the drug must instead be dosed volumetrically by ~~first~~ dissolving ~~a known weight of material~~ in a calculated volume of suitable ~~solvent~~.

==Solvent==

~~Most~~ benzodiazepines are practically insoluble in water, but will dissolve at various concentrations in other easy to acquire solvents;

Certain psychoactive substances (particularly benzodiazepines) are practically insoluble in water, but will dissolve at various concentrations in other easy to acquire solvents. These include:

* Ethanol

* [[Ethanol]]

* Propylene glycol

* Glycerine

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==Measurement==

===Solvent===

For best accuracy, a syringe should be used to measure the calculated volume of liquid. For efficient dosing, a 1ml syringe with 0.1ml graduations can be used with solutions at a concentration of 10mg/1ml; this provides 1mg/0.1ml graduation. It may be better to use a lower concentration if your usual dose is below 1mg.

For best accuracy, an oral syringe should be used to measure the calculated volume of liquid. For efficient dosing, a 1ml syringe with 0.1ml graduations can be used with solutions at a concentration of 10mg/1ml; this provides 1mg/0.1ml graduation. It may be better to use a lower concentration if your usual dose is below 1mg.

===Powder===

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==Dissolution==

After weighing the material, calculating the concentration, and measuring the required volume of solvent; using a suitable container add the ~~solvent~~ then carefully mix in the ~~benzodiazepine powder~~. Seal tightly and mix thoroughly by ~~inverting~~ the container vigorously.

After weighing the material, calculating the concentration, and measuring the required volume of solvent; using a suitable container add the liquid then carefully mix in the compound. Seal tightly and mix thoroughly by shaking the container vigorously.

To aid in dissolution, the container can be placed in a heat bath to warm it up. After a while the solvent will become less viscous and can be mixed more thoroughly.

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 {{Disclaimer}}
+Volumetric dosing is the process of dissolving a compound in a liquid to make it easier to measure. In the interest of harm reduction, it is essential to prepare certain compounds which are too potent to measure with traditional weighing scales within a liquid solution.
-<div style="border: 1px solid #b75; background: #fef7f5; padding: 1em; margin-bottom: 1em; padding: 1em .5em;">[[File:Attention_niels_epting.svg|frameless|link=|25px]] It is probably best to avoid carrying out this procedure while already under the influence of amnesic sedatives.
+Many psychoactive substances, including [[benzodiazepines]] and certain [[psychedelics]], are active at less than a single milligram. Such small quantities cannot be accurately measured with common digital scales, so the drug must instead be dosed volumetrically by weighing out larger amounts the compound and dissolving it in a calculated volume of a suitable liquid.
-</div>
-In the interest of harm reduction, it is essential to prepare solutions from [[benzodiazepine]] powders.
-Many benzodiazepines, including [[alprazolam]] and [[etizolam]], are active at less than a single milligram. Such small quantities cannot be accurately measured with common digital scales, so the drug must instead be dosed volumetrically by first dissolving a known weight of material in a calculated volume of suitable solvent.
 ==Solvent==
-Most benzodiazepines are practically insoluble in water, but will dissolve at various concentrations in other easy to acquire solvents;
+Certain psychoactive substances (particularly benzodiazepines) are practically insoluble in water, but will dissolve at various concentrations in other easy to acquire solvents. These include:
-* Ethanol
+* [[Ethanol]]
 * Propylene glycol
 * Glycerine
@@ Line 21: / Line 17: @@
 ==Measurement==
 ===Solvent===
-For best accuracy, a syringe should be used to measure the calculated volume of liquid. For efficient dosing, a 1ml syringe with 0.1ml graduations can be used with solutions at a concentration of 10mg/1ml; this provides 1mg/0.1ml graduation. It may be better to use a lower concentration if your usual dose is below 1mg.
+For best accuracy, an oral syringe should be used to measure the calculated volume of liquid. For efficient dosing, a 1ml syringe with 0.1ml graduations can be used with solutions at a concentration of 10mg/1ml; this provides 1mg/0.1ml graduation. It may be better to use a lower concentration if your usual dose is below 1mg.
 ===Powder===
@@ Line 29: / Line 25: @@
 ==Dissolution==
-After weighing the material, calculating the concentration, and measuring the required volume of solvent; using a suitable container add the solvent then carefully mix in the benzodiazepine powder. Seal tightly and mix thoroughly by inverting the container vigorously.
+After weighing the material, calculating the concentration, and measuring the required volume of solvent; using a suitable container add the liquid then carefully mix in the compound. Seal tightly and mix thoroughly by shaking the container vigorously.
 To aid in dissolution, the container can be placed in a heat bath to warm it up. After a while the solvent will become less viscous and can be mixed more thoroughly.