Routes of administration: Difference between revisions

Rectal administration, also commonly referred to as plugging, is one of the most effective methods of administration for many substances.<ref>http://jpet.aspetjournals.org/content/244/1/23.short</ref> <ref>http://bja.oxfordjournals.org/content/56/1/69.extract</ref> The absorption rate is very high compared to other methods and onset is usually very short, generally with a higher intensity and shorter duration. This is due to the large amount of arteries located in the rectum, thus rectal administration is often superior to other methods, despite social stigma.