Pregabalin: Difference between revisions
>Pharmasnuff I changed "reduces" to modulates the excitatory transmitters, reduction is not the only mechanism of action that pregabalin has on the listed excitatory neurtransmitters |
>Plein more info on anxiolytic effect |
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The most prominent of these cognitive effects generally include: | The most prominent of these cognitive effects generally include: | ||
*'''[[Effect::Dizziness]]''' - The after effects are mostly positive with pregabalin, but dizziness can still be here, especially after doing a high dose. | |||
*'''[[Effect::Anxiety suppression]]''' | |||
*'''[[Effect::Analysis suppression]]''' | *'''[[Effect::Analysis suppression]]''' | ||
It suppresses lingering, recurrent thoughts of anxiety, which is presented as dizziness. It can paradoxically produce looming anxiety at doses slightly above minimally-effective dose. That's the subtle difference between Gabapentinoids and Benzos | |||
* '''[[Effect::Empathy, affection, and sociability enhancement]]''' - Pregabalin presents distinct [[entactogen|entactogen/empathogenic]] effects. In contrast to [[benzodiazepines]] (which merely increase sociability through [[disinhibition]]), at high dosages pregabalin directly increases the urge to communicate with others with feelings of empathy, love, closeness and connection being well-defined. These effects, although weaker than that of [[MDMA]], are still prominent. | * '''[[Effect::Empathy, affection, and sociability enhancement]]''' - Pregabalin presents distinct [[entactogen|entactogen/empathogenic]] effects. In contrast to [[benzodiazepines]] (which merely increase sociability through [[disinhibition]]), at high dosages pregabalin directly increases the urge to communicate with others with feelings of empathy, love, closeness and connection being well-defined. These effects, although weaker than that of [[MDMA]], are still prominent. | ||
*'''[[Effect::Ego inflation]]''' | *'''[[Effect::Ego inflation]]''' | ||
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*'''[[Effect::Suggestibility enhancement]]''' | *'''[[Effect::Suggestibility enhancement]]''' | ||
*'''[[Effect::Amnesia]]''' - Compared to [[benzodiazepines]], pregabalin is only mildly amnesiac if not combined with other depressants. With chronic usage or high dosages, one should expect more "tip of the tongue" moments and impaired short-term memory (e.g., walking into a room and forgetting what you were supposed to do there). Total blackouts do not seem to occur except in combination with other substances. | *'''[[Effect::Amnesia]]''' - Compared to [[benzodiazepines]], pregabalin is only mildly amnesiac if not combined with other depressants. With chronic usage or high dosages, one should expect more "tip of the tongue" moments and impaired short-term memory (e.g., walking into a room and forgetting what you were supposed to do there). Total blackouts do not seem to occur except in combination with other substances. | ||
*'''[[Effect::Emotion enhancement]]''' | *'''[[Effect::Emotion enhancement]]''' | ||
*'''[[Effect::Cognitive euphoria]]'''<ref>{{cite book | date= 2012 | title=Abuse and Misuse Potential of Pregabalin: A Review of the Clinical Evidence | publisher=Canadian Agency for Drugs and Technologies in Health}}</ref> - Many users who take pregabalin describe a moderate to even intense euphoria, even at lower doses. Many users describe it as similar to [[opioid]] induced euphoria. The sensation itself can be described as powerful and overwhelming feelings of emotional bliss, contentment, and happiness. | *'''[[Effect::Cognitive euphoria]]'''<ref>{{cite book | date= 2012 | title=Abuse and Misuse Potential of Pregabalin: A Review of the Clinical Evidence | publisher=Canadian Agency for Drugs and Technologies in Health}}</ref> - Many users who take pregabalin describe a moderate to even intense euphoria, even at lower doses. Many users describe it as similar to [[opioid]] induced euphoria. The sensation itself can be described as powerful and overwhelming feelings of emotional bliss, contentment, and happiness. | ||
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*'''[[Effect::Muscle relaxation]]''' - This effect is not as strong as the high but its still here in the afterglow. | *'''[[Effect::Muscle relaxation]]''' - This effect is not as strong as the high but its still here in the afterglow. | ||
*'''[[Effect::Motor control loss]]''' - This effect is weaker than the ''high'' but is still noticeable to the user. Driving while in the ''afterglow'' / comedown is a bad idea. | *'''[[Effect::Motor control loss]]''' - This effect is weaker than the ''high'' but is still noticeable to the user. Driving while in the ''afterglow'' / comedown is a bad idea. | ||
}} | }} |