Tetrahydrocannabiphorol: Difference between revisions

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'''Tetrahydrocannabiphorol''' ('''THCP''') is a potent phytocannabinoid that is structurally similar to delta-9-THC, the main psychoactive compound in cannabis. Like THC, THCP is a CB1 and CB2 receptor agonist ~~and is believed to have~~ psychoactive effects. Initial studies suggest that THCP may be up to 30 times more potent than delta-9-THC,<ref>https://www.livescience.com/new-potent-cannabinoid.html</ref> potentially leading to more pronounced psychoactive effects. However, the full extent of THCP's psychoactivity and how it compares to THC is still being researched.

'''Tetrahydrocannabiphorol''' ('''THCP''') is a potent phytocannabinoid that is structurally similar to delta-9-THC, the main psychoactive compound in cannabis. Like THC, THCP is a CB1 and CB2 receptor agonist with psychoactive effects. Initial in-vitro binding assay studies suggest that THCP may be up to 30 times more potent than delta-9-THC,<ref name="Citti et al 2019">{{cite journal | vauthors = Citti C, Linciano P, Russo F, Luongo L, Iannotta M, Maione S, Laganà A, Capriotti AL, Forni F, Vandelli MA, Gigli G, Cannazza G | title = A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ<sup>9</sup>-tetrahydrocannabinol: Δ<sup>9</sup>-Tetrahydrocannabiphorol | journal = Scientific Reports | volume = 9 | issue = 1 | pages = 20335 | date = December 2019 | pmid = 31889124 | pmc = 6937300 | doi = 10.1038/s41598-019-56785-1 | bibcode = 2019NatSR...920335C }}</ref><ref>https://www.livescience.com/new-potent-cannabinoid.html</ref> potentially leading to more pronounced psychoactive effects. However, the full extent of THCP's psychoactivity and how it compares to THC is still being researched.

==History and culture==

==Pharmacology==

[[File:Tetrahydrocannabiphorol_Ki.png|thumbnail|250px|right|Binding affinities of THCP for CB1 and CB2 receptors, with D8/D9 THC comparisons.<ref name="Citti et al 2019"></ref>]]

==Subjective effects==

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-'''Tetrahydrocannabiphorol''' ('''THCP''') is a potent phytocannabinoid that is structurally similar to delta-9-THC, the main psychoactive compound in cannabis. Like THC, THCP is a CB1 and CB2 receptor agonist and is believed to have psychoactive effects. Initial studies suggest that THCP may be up to 30 times more potent than delta-9-THC,<ref>https://www.livescience.com/new-potent-cannabinoid.html</ref> potentially leading to more pronounced psychoactive effects. However, the full extent of THCP's psychoactivity and how it compares to THC is still being researched.
+'''Tetrahydrocannabiphorol''' ('''THCP''') is a potent phytocannabinoid that is structurally similar to delta-9-THC, the main psychoactive compound in cannabis. Like THC, THCP is a CB1 and CB2 receptor agonist with psychoactive effects. Initial in-vitro binding assay studies suggest that THCP may be up to 30 times more potent than delta-9-THC,<ref name="Citti et al 2019">{{cite journal | vauthors = Citti C, Linciano P, Russo F, Luongo L, Iannotta M, Maione S, Laganà A, Capriotti AL, Forni F, Vandelli MA, Gigli G, Cannazza G | title = A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ<sup>9</sup>-tetrahydrocannabinol: Δ<sup>9</sup>-Tetrahydrocannabiphorol | journal = Scientific Reports | volume = 9 | issue = 1 | pages = 20335 | date = December 2019 | pmid = 31889124 | pmc = 6937300 | doi = 10.1038/s41598-019-56785-1 | bibcode = 2019NatSR...920335C }}</ref><ref>https://www.livescience.com/new-potent-cannabinoid.html</ref> potentially leading to more pronounced psychoactive effects. However, the full extent of THCP's psychoactivity and how it compares to THC is still being researched.
 ==History and culture==
 ==Pharmacology==
+[[File:Tetrahydrocannabiphorol_Ki.png|thumbnail|250px|right|Binding affinities of THCP for CB1 and CB2 receptors, with D8/D9 THC comparisons.<ref name="Citti et al 2019"></ref>]]
 ==Subjective effects==