Cocaine/Synthesis: Difference between revisions

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'''Methylecgonine'''

0.4 mole of ~~tropinone~~ is suspended in 80 ml of ethanol in a Parr hydrogenation flask (or something that can take 100 psi and not react with the reaction, like stainless steel or glass). 10 g of Raney Nickle is added with good agitation (stirring or shaking) followed by 2-3 ml of 20% NaOH solution. Seal vessel, introduce 50 psi of hydrogen atmosphere (after flushing vessel with hydrogen) and heat to 40-50°C. After no more uptake of hydrogen (pressure gauge will hold steady after dropping to its lowest point) bleed off pressure and filter the nickle off, rinse out bottle with chloroform and use this rinse to rinse off the nickle while still on the filter paper. Make the filtrate basic with KOH after cooling to 10°C. Extract with chloroform dry, and evaporate the chloroform in vacuo to get an oil. Mix the oil plus any precipitate with an equal volume of dry ether and filter. Add more dry ether to the filtrate until no more precipitate forms, filter and add to the rest of the precipitate. Recrystallize from isopropanol to get pure methylecgonine. Test for activity. If active, skip down to the step for cocaine. If not active, proceed as follows. Stir with activated carbon for 30 min, filter, evaporate in vacuo, dissolve the brown liquid in methanol, and neutralize with 10% HCl acid in dry ether. Evaporate the ether until the two layers disappear, and allow to stand for 2 hours at 0°C to precipitate the title product. There are many ways to reduce 2-carbomethoxytropinone to methylecgonine. I chose to design a Raney Nickle reduction because it is cheap and not as suspicious as LAH and it is much easier than zinc or sodium amalgams.

0.4 mole of 2-Carbomethoxytropinone is suspended in 80 ml of ethanol in a Parr hydrogenation flask (or something that can take 100 psi and not react with the reaction, like stainless steel or glass). 10 g of Raney Nickle is added with good agitation (stirring or shaking) followed by 2-3 ml of 20% NaOH solution. Seal vessel, introduce 50 psi of hydrogen atmosphere (after flushing vessel with hydrogen) and heat to 40-50°C. After no more uptake of hydrogen (pressure gauge will hold steady after dropping to its lowest point) bleed off pressure and filter the nickle off, rinse out bottle with chloroform and use this rinse to rinse off the nickle while still on the filter paper. Make the filtrate basic with KOH after cooling to 10°C. Extract with chloroform dry, and evaporate the chloroform in vacuo to get an oil. Mix the oil plus any precipitate with an equal volume of dry ether and filter. Add more dry ether to the filtrate until no more precipitate forms, filter and add to the rest of the precipitate. Recrystallize from isopropanol to get pure methylecgonine. Test for activity. If active, skip down to the step for cocaine. If not active, proceed as follows. Stir with activated carbon for 30 min, filter, evaporate in vacuo, dissolve the brown liquid in methanol, and neutralize with 10% HCl acid in dry ether. Evaporate the ether until the two layers disappear, and allow to stand for 2 hours at 0°C to precipitate the title product. There are many ways to reduce 2-carbomethoxytropinone to methylecgonine. I chose to design a Raney Nickle reduction because it is cheap and not as suspicious as LAH and it is much easier than zinc or sodium amalgams.

'''Cocaine'''

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'''Overview'''

Here we are obtaining tropine to create tropinone from a natural source; the anticholinergic tropane alkaloids such as atropine, scopolamine, hyocyamine, mandragovine, and other similar tropane alkaloids obtained from the plants in the [https://en.wikipedia.org/wiki/Solanaceae Solanaceae family], such Belladonna, Datura, Henbane, Brugmansia, and Mandrake. Tropane alkaloids all contain the tropane ring which, when separated from the tropic, scopic, and hyoscopic, and similar acids becomes tropine, which we can use as a source chemical to produce tropinone, which is necessary for creation of synthetic cocaine. These plants grow in most of the parts of the world. By using this route to produce cocaine the plants can be grown in country, so the cocaine does not need to be transported very far, making it extremely cheap. With this semi-synthetic synthesis we can grow these plants nearly anywhere in the world ~~except Antarctica~~, make cocaine cheaply within the country without having to transport it or cut it, to ensure harm reduction and that the cartels, traffickers, and other such dangerous criminals are out of a f*cking job. This extraction and synthesis is untested, so if you somehow have legal permission to perform this process then by all means please do confirm. We can create tropine for the above tropinone syntheses, or we could follow a one-pot synthesis method using a conductive metal vessel as our pot for the one-pot synthesis method.

Here we are obtaining tropine to create tropinone from a natural source; the anticholinergic tropane alkaloids such as atropine, scopolamine, hyocyamine, mandragovine, and other similar tropane alkaloids obtained from the plants in the [https://en.wikipedia.org/wiki/Solanaceae Solanaceae family], such Belladonna, Datura, Henbane, Brugmansia, and Mandrake. Tropane alkaloids all contain the tropane ring which, when separated from the tropic, scopic, and hyoscopic, and similar acids becomes tropine, which we can use as a source chemical to produce tropinone, which is necessary for creation of synthetic cocaine. These plants grow in most of the parts of the world. By using this route to produce cocaine the plants can be grown in country, so the cocaine does not need to be transported very far, making it extremely cheap. With this semi-synthetic synthesis we can grow these plants nearly anywhere in the world, make cocaine cheaply within the country without having to transport it or cut it, to ensure harm reduction and that the cartels, traffickers, and other such dangerous criminals are out of a f*cking job.

'''Extraction'''

A boiling water extraction is used to extract the tropane alkaloids from the plant material. A sheet of cloth as a filter is put down in a container and water is boiled in said container. The plants are then pulled up by the roots, washed with water, and then placed in the container and pulverized and macerated while under the water with an appropriate utensil such as a piece of wood or a pipe. Keeping a lid on the container at all times will preclude spattering, which could absorb through your skin giving you anticholinergic poisoning. After the brew has boiled for some time pull up the cloth as a filter, leaving the extracted alkaloids in the water. Boil down the water for a concentrated solution of tropane alkaloids. Multiple extractions ~~with both~~ the same and different plant matter from another vessel(s) and transferred and boiled down in the main vessel will result in a concentrated aqueous solution of tropane alkaloids.

A boiling water extraction is used to extract the tropane alkaloids from the plant material. A sheet of cloth as a filter is put down in a container and water is boiled in said container. The plants are then pulled up by the roots, washed with water, and then placed in the container and pulverized and macerated while under the water with an appropriate utensil such as a piece of wood or a pipe. Keeping a lid on the container at all times will preclude spattering, which could absorb through your skin giving you anticholinergic poisoning. After the brew has boiled for some time pull up the cloth as a filter, leaving the extracted alkaloids in the water. Boil down the water for a concentrated solution of tropane alkaloids. Multiple extractions of the same plant matter, and multiple extractions of different plant matter from another vessel(s) and transferred and boiled down in the main vessel will result in a concentrated aqueous solution of tropane alkaloids.

'''Hydrolysis'''

The concentrated solution of tropane alkaloids has sodium hydroxide (lye) added to it, which binds with the hydrolyzed acids to make sodium acid salts and tropine in the aqueous solution. The solution can be boiled down and the tropine extracted with anhydrous ethanol for the two above tropinone syntheses involving tropine. Or we can ~~leave~~ the ~~acid salts within~~ the container ~~for our one-pot semi-synthetic synthesis method~~.

The concentrated solution of tropane alkaloids has sodium hydroxide (NaOH or lye) added to it, which binds with the hydrolyzed acids to make sodium acid salts and tropine in the aqueous solution. The solution can be boiled down and the tropine extracted with anhydrous ethanol for the two above tropinone syntheses involving tropine.

'''Hydrogenation'''

For the hydrogenation reaction above we can use a (sealable) conductive metal container or two conductive metal objects in the ethanolic solution containing the NaOH acting as an electrolyte, such as sodium hydroxide (NaOH or lye), we can set up an electrolysis reaction for a sort of sparging situation where hydrogen bubbles up through the (sealable) metal container acting like a hydrogenator. This setup may be much easier and less suspicious than a conventional hydrogenator.

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 '''Methylecgonine'''
-.4 mole of tropinone is suspended in 80 ml of ethanol in a Parr hydrogenation flask (or something that can take 100 psi and not react with the reaction, like stainless steel or glass). 10 g of Raney Nickle is added with good agitation (stirring or shaking) followed by 2-3 ml of 20% NaOH solution. Seal vessel, introduce 50 psi of hydrogen atmosphere (after flushing vessel with hydrogen) and heat to 40-50°C. After no more uptake of hydrogen (pressure gauge will hold steady after dropping to its lowest point) bleed off pressure and filter the nickle off, rinse out bottle with chloroform and use this rinse to rinse off the nickle while still on the filter paper. Make the filtrate basic with KOH after cooling to 10°C. Extract with chloroform dry, and evaporate the chloroform in vacuo to get an oil. Mix the oil plus any precipitate with an equal volume of dry ether and filter. Add more dry ether to the filtrate until no more precipitate forms, filter and add to the rest of the precipitate. Recrystallize from isopropanol to get pure methylecgonine. Test for activity. If active, skip down to the step for cocaine. If not active, proceed as follows. Stir with activated carbon for 30 min, filter, evaporate in vacuo, dissolve the brown liquid in methanol, and neutralize with 10% HCl acid in dry ether. Evaporate the ether until the two layers disappear, and allow to stand for 2 hours at 0°C to precipitate the title product. There are many ways to reduce 2-carbomethoxytropinone to methylecgonine. I chose to design a Raney Nickle reduction because it is cheap and not as suspicious as LAH and it is much easier than zinc or sodium amalgams.
+.4 mole of 2-Carbomethoxytropinone is suspended in 80 ml of ethanol in a Parr hydrogenation flask (or something that can take 100 psi and not react with the reaction, like stainless steel or glass). 10 g of Raney Nickle is added with good agitation (stirring or shaking) followed by 2-3 ml of 20% NaOH solution. Seal vessel, introduce 50 psi of hydrogen atmosphere (after flushing vessel with hydrogen) and heat to 40-50°C. After no more uptake of hydrogen (pressure gauge will hold steady after dropping to its lowest point) bleed off pressure and filter the nickle off, rinse out bottle with chloroform and use this rinse to rinse off the nickle while still on the filter paper. Make the filtrate basic with KOH after cooling to 10°C. Extract with chloroform dry, and evaporate the chloroform in vacuo to get an oil. Mix the oil plus any precipitate with an equal volume of dry ether and filter. Add more dry ether to the filtrate until no more precipitate forms, filter and add to the rest of the precipitate. Recrystallize from isopropanol to get pure methylecgonine. Test for activity. If active, skip down to the step for cocaine. If not active, proceed as follows. Stir with activated carbon for 30 min, filter, evaporate in vacuo, dissolve the brown liquid in methanol, and neutralize with 10% HCl acid in dry ether. Evaporate the ether until the two layers disappear, and allow to stand for 2 hours at 0°C to precipitate the title product. There are many ways to reduce 2-carbomethoxytropinone to methylecgonine. I chose to design a Raney Nickle reduction because it is cheap and not as suspicious as LAH and it is much easier than zinc or sodium amalgams.
 '''Cocaine'''
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 '''Overview'''
-Here we are obtaining tropine to create tropinone from a natural source; the anticholinergic tropane alkaloids such as atropine, scopolamine, hyocyamine, mandragovine, and other similar tropane alkaloids obtained from the plants in the [https://en.wikipedia.org/wiki/Solanaceae Solanaceae family], such Belladonna, Datura, Henbane, Brugmansia, and Mandrake. Tropane alkaloids all contain the tropane ring which, when separated from the tropic, scopic, and hyoscopic, and similar acids becomes tropine, which we can use as a source chemical to produce tropinone, which is necessary for creation of synthetic cocaine. These plants grow in most of the parts of the world. By using this route to produce cocaine the plants can be grown in country, so the cocaine does not need to be transported very far, making it extremely cheap. With this semi-synthetic synthesis we can grow these plants nearly anywhere in the world except Antarctica, make cocaine cheaply within the country without having to transport it or cut it, to ensure harm reduction and that the cartels, traffickers, and other such dangerous criminals are out of a f*cking job. This extraction and synthesis is untested, so if you somehow have legal permission to perform this process then by all means please do confirm. We can create tropine for the above tropinone syntheses, or we could follow a one-pot synthesis method using a conductive metal vessel as our pot for the one-pot synthesis method.
+Here we are obtaining tropine to create tropinone from a natural source; the anticholinergic tropane alkaloids such as atropine, scopolamine, hyocyamine, mandragovine, and other similar tropane alkaloids obtained from the plants in the [https://en.wikipedia.org/wiki/Solanaceae Solanaceae family], such Belladonna, Datura, Henbane, Brugmansia, and Mandrake. Tropane alkaloids all contain the tropane ring which, when separated from the tropic, scopic, and hyoscopic, and similar acids becomes tropine, which we can use as a source chemical to produce tropinone, which is necessary for creation of synthetic cocaine. These plants grow in most of the parts of the world. By using this route to produce cocaine the plants can be grown in country, so the cocaine does not need to be transported very far, making it extremely cheap. With this semi-synthetic synthesis we can grow these plants nearly anywhere in the world, make cocaine cheaply within the country without having to transport it or cut it, to ensure harm reduction and that the cartels, traffickers, and other such dangerous criminals are out of a f*cking job.
 '''Extraction'''
-A boiling water extraction is used to extract the tropane alkaloids from the plant material. A sheet of cloth as a filter is put down in a container and water is boiled in said container. The plants are then pulled up by the roots, washed with water, and then placed in the container and pulverized and macerated while under the water with an appropriate utensil such as a piece of wood or a pipe. Keeping a lid on the container at all times will preclude spattering, which could absorb through your skin giving you anticholinergic poisoning. After the brew has boiled for some time pull up the cloth as a filter, leaving the extracted alkaloids in the water. Boil down the water for a concentrated solution of tropane alkaloids. Multiple extractions with both the same and different plant matter from another vessel(s) and transferred and boiled down in the main vessel will result in a concentrated aqueous solution of tropane alkaloids.
+A boiling water extraction is used to extract the tropane alkaloids from the plant material. A sheet of cloth as a filter is put down in a container and water is boiled in said container. The plants are then pulled up by the roots, washed with water, and then placed in the container and pulverized and macerated while under the water with an appropriate utensil such as a piece of wood or a pipe. Keeping a lid on the container at all times will preclude spattering, which could absorb through your skin giving you anticholinergic poisoning. After the brew has boiled for some time pull up the cloth as a filter, leaving the extracted alkaloids in the water. Boil down the water for a concentrated solution of tropane alkaloids. Multiple extractions of the same plant matter, and multiple extractions of different plant matter from another vessel(s) and transferred and boiled down in the main vessel will result in a concentrated aqueous solution of tropane alkaloids.
 '''Hydrolysis'''
-The concentrated solution of tropane alkaloids has sodium hydroxide (lye) added to it, which binds with the hydrolyzed acids to make sodium acid salts and tropine in the aqueous solution. The solution can be boiled down and the tropine extracted with anhydrous ethanol for the two above tropinone syntheses involving tropine. Or we can leave the acid salts within the container for our one-pot semi-synthetic synthesis method.
+The concentrated solution of tropane alkaloids has sodium hydroxide (NaOH or lye) added to it, which binds with the hydrolyzed acids to make sodium acid salts and tropine in the aqueous solution. The solution can be boiled down and the tropine extracted with anhydrous ethanol for the two above tropinone syntheses involving tropine.
+'''Hydrogenation'''
+For the hydrogenation reaction above we can use a (sealable) conductive metal container or two conductive metal objects in the ethanolic solution containing the NaOH acting as an electrolyte, such as sodium hydroxide (NaOH or lye), we can set up an electrolysis reaction for a sort of sparging situation where hydrogen bubbles up through the (sealable) metal container acting like a hydrogenator. This setup may be much easier and less suspicious than a conventional hydrogenator.