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Routes of administration: Difference between revisions
>David Hedlund |
>David Hedlund Oral mucosa |
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[[25I-NBOMe]] is widely rumored to be orally inactive; however, apparent overdoses have occurred via oral administration. | [[25I-NBOMe]] is widely rumored to be orally inactive; however, apparent overdoses have occurred via oral administration. | ||
===Sublingual=== | ===Oral mucosa=== | ||
====Sublingual==== | |||
Sublingual administration refers to absorption under the tongue.<ref name="DeBoer1984">{{cite journal | vauthors=((De Boer, A. G.)), ((De Leede, L. G. J.)), ((Breimer, D. D.)) | journal=British Journal of Anaesthesia | title=DRUG ABSORPTION BY SUBLINGUAL AND RECTAL ROUTES | volume=56 | issue=1 | pages=69–82 | date= January 1984 | url=https://linkinghub.elsevier.com/retrieve/pii/S000709121742397X | issn=00070912 | doi=10.1093/bja/56.1.69}}</ref> It is a common route of administration for [[lysergamides]] like [[LSD]]. | Sublingual administration refers to absorption under the tongue.<ref name="DeBoer1984">{{cite journal | vauthors=((De Boer, A. G.)), ((De Leede, L. G. J.)), ((Breimer, D. D.)) | journal=British Journal of Anaesthesia | title=DRUG ABSORPTION BY SUBLINGUAL AND RECTAL ROUTES | volume=56 | issue=1 | pages=69–82 | date= January 1984 | url=https://linkinghub.elsevier.com/retrieve/pii/S000709121742397X | issn=00070912 | doi=10.1093/bja/56.1.69}}</ref> It is a common route of administration for [[lysergamides]] like [[LSD]]. | ||
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It also circumvents first-pass metabolism of certain substances which can be absorbed via sublingual and buccal administration but not oral administration (e.g. [[25x-NBOMe]], [[25x-NBOH]]). | It also circumvents first-pass metabolism of certain substances which can be absorbed via sublingual and buccal administration but not oral administration (e.g. [[25x-NBOMe]], [[25x-NBOH]]). | ||
====Risks==== | =====Risks===== | ||
Caustic compounds, such as the freebase form of amine-containing substance, should not be used sublingually because they can severely burn the inside of one's mouth. | Caustic compounds, such as the freebase form of amine-containing substance, should not be used sublingually because they can severely burn the inside of one's mouth. | ||
===Buccal=== | ====Buccal==== | ||
[[File:Dipping tobacco in mouth.jpg|thumb|right|[[Dipping tobacco]] is placed directly in the mouth.]] | [[File:Dipping tobacco in mouth.jpg|thumb|right|[[Dipping tobacco]] is placed directly in the mouth.]] | ||
