Routes of administration: Difference between revisions

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==Safety precautions for certain substances==

===~~DMT~~===

===Orally inactive substances===

* ~~Oral~~: ~~Oral~~ [[DMT]] is inactive because stomach enzymes called MAO enzymes break it down. To experience effects orally, ~~DMT is~~ frequently combined with [[MAO inhibitor]]s (MAOIs), which prevent this breakdown. This combination is known as [[pharmahuasca]]. When the MAOIs and DMT are derived from plant extracts, it is referred to as [[ayahuasca]].

* Substances: [[5-MeO-DMT]], [[DMT]].

* Insufflation (snorting): ~~[[DMT]], when~~ delivered intranasally (through the nose), can deposit along the nasal passage and drip down into the gastrointestinal tract. Absorption through this route is inefficient, and any DMT swallowed undergoes rapid enzymatic degradation in the stomach, rendering it inactive. This can introduce variability in effect intensity among users. Inconclusive experiences due to swallowed DMT may lead to a false sense of security, potentially causing users to increase the dose in subsequent administrations. However, due to the unpredictable nature of intranasal dripping, this could result in an unexpectedly potent dose due to less DMT being metabolized in the stomach.

* Routes of administration

** Oral: When these substances are taken orally, they are inactive because stomach enzymes called MAO enzymes break it down. To experience effects orally, they are frequently combined with [[MAO inhibitor]]s (MAOIs), which prevent this breakdown. This combination is known as [[pharmahuasca]] for [[DMT]] (or [[5-MeO-DMT]]). When the MAOIs and DMT are derived from plant extracts, it is referred to as [[ayahuasca]].

** Insufflation (snorting): When these substances are delivered intranasally (through the nose), they can deposit along the nasal passage and drip down into the gastrointestinal tract. Absorption through this route is inefficient, and any DMT swallowed undergoes rapid enzymatic degradation in the stomach, rendering it inactive. This can introduce variability in effect intensity among users. Inconclusive experiences due to swallowed DMT may lead to a false sense of security, potentially causing users to increase the dose in subsequent administrations. However, due to the unpredictable nature of intranasal dripping, this could result in an unexpectedly potent dose due to less DMT being metabolized in the stomach.

==Oral cavity==

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 ==Safety precautions for certain substances==
-===DMT===
+===Orally inactive substances===
-* Oral: Oral [[DMT]] is inactive because stomach enzymes called MAO enzymes break it down. To experience effects orally, DMT is frequently combined with [[MAO inhibitor]]s (MAOIs), which prevent this breakdown. This combination is known as [[pharmahuasca]]. When the MAOIs and DMT are derived from plant extracts, it is referred to as [[ayahuasca]].
+* Substances: [[5-MeO-DMT]], [[DMT]].
-* Insufflation (snorting): [[DMT]], when delivered intranasally (through the nose), can deposit along the nasal passage and drip down into the gastrointestinal tract.  Absorption through this route is inefficient, and any DMT swallowed undergoes rapid enzymatic degradation in the stomach, rendering it inactive. This can introduce variability in effect intensity among users. Inconclusive experiences due to swallowed DMT may lead to a false sense of security, potentially causing users to increase the dose in subsequent administrations. However, due to the unpredictable nature of intranasal dripping, this could result in an unexpectedly potent dose due to less DMT being metabolized in the stomach.
+* Routes of administration
+** Oral: When these substances are taken orally, they are inactive because stomach enzymes called MAO enzymes break it down. To experience effects orally, they are frequently combined with [[MAO inhibitor]]s (MAOIs), which prevent this breakdown. This combination is known as [[pharmahuasca]] for [[DMT]] (or [[5-MeO-DMT]]). When the MAOIs and DMT are derived from plant extracts, it is referred to as [[ayahuasca]].
+** Insufflation (snorting): When these substances are delivered intranasally (through the nose), they can deposit along the nasal passage and drip down into the gastrointestinal tract. Absorption through this route is inefficient, and any DMT swallowed undergoes rapid enzymatic degradation in the stomach, rendering it inactive. This can introduce variability in effect intensity among users. Inconclusive experiences due to swallowed DMT may lead to a false sense of security, potentially causing users to increase the dose in subsequent administrations. However, due to the unpredictable nature of intranasal dripping, this could result in an unexpectedly potent dose due to less DMT being metabolized in the stomach.
 ==Oral cavity==