Routes of administration: Difference between revisions

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Determining an optimal route of administration is highly dependent on the substance consumed, its desired duration and potency and side effects, and one's personal comfort level.

==Safety precautions for certain substances==

===DMT===

* Oral: [[DMT]] is inactive when taken by mouth because enzymes in your stomach (MAO enzymes) break it down. To achieve effects orally, DMT is often combined with MAO inhibitors (MAOIs) which prevent this breakdown. Examples of such combinations include pharmahuasca and ayahuasca (be aware these combinations can be dangerous).

* Insufflation (Snorting): DMT absorbed through the nose may drip down your throat and be swallowed. If swallowed, it will be broken down in your stomach and have no effect.

==Oral cavity==

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====Risks====

This method can also have a greater propensity for [[nausea]] and gastrointestinal discomfort.<ref>{{cite journal | vauthors=((Niv, D.)), ((Davidovich, S.)), ((Geller, E.)), ((Urca, G.)) | journal=Anesthesia and Analgesia | title=Analgesic and hyperalgesic effects of midazolam: dependence on route of administration | volume=67 | issue=12 | pages=1169–1173 | date= December 1988 | issn=0003-2999}}</ref><ref>{{Citation | vauthors=((Porter, W. R.)) | title=Intraoral methods of using benzodiazepines | url=https://patents.google.com/patent/US4229447/en}}</ref>

Non-oral administration methods circumvent the gastrointestinal tract's breakdown of certain compounds like [[DMT]], which would otherwise necessitate the use of [[monoamine oxidase inhibitor]]s (MAOIs), referred to as [[pharmahuasca]] or [[ayahuasca]] when the MAOI and DMT originate from plant extracts, if ingested orally. However, combining MAOIs with many psychoactive substances or tyramine-rich foods can be extremely dangerous.

===Sublingual===

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 Determining an optimal route of administration is highly dependent on the substance consumed, its desired duration and potency and side effects, and one's personal comfort level.
+==Safety precautions for certain substances==
+===DMT===
+* Oral: [[DMT]] is inactive when taken by mouth because enzymes in your stomach (MAO enzymes) break it down. To achieve effects orally, DMT is often combined with MAO inhibitors (MAOIs) which prevent this breakdown. Examples of such combinations include pharmahuasca and ayahuasca (be aware these combinations can be dangerous).
+* Insufflation (Snorting): DMT absorbed through the nose may drip down your throat and be swallowed. If swallowed, it will be broken down in your stomach and have no effect.
 ==Oral cavity==
@@ Line 16: / Line 22: @@
 ====Risks====
 This method can also have a greater propensity for [[nausea]] and gastrointestinal discomfort.<ref>{{cite journal | vauthors=((Niv, D.)), ((Davidovich, S.)), ((Geller, E.)), ((Urca, G.)) | journal=Anesthesia and Analgesia | title=Analgesic and hyperalgesic effects of midazolam: dependence on route of administration | volume=67 | issue=12 | pages=1169–1173 | date= December 1988 | issn=0003-2999}}</ref><ref>{{Citation | vauthors=((Porter, W. R.)) | title=Intraoral methods of using benzodiazepines | url=https://patents.google.com/patent/US4229447/en}}</ref>
-Non-oral administration methods circumvent the gastrointestinal tract's breakdown of certain compounds like [[DMT]], which would otherwise necessitate the use of [[monoamine oxidase inhibitor]]s (MAOIs), referred to as [[pharmahuasca]] or [[ayahuasca]] when the MAOI and DMT originate from plant extracts, if ingested orally. However, combining MAOIs with many psychoactive substances or tyramine-rich foods can be extremely dangerous.
 ===Sublingual===