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Methylphenidate: Difference between revisions
>David Hedlund Added ===Alcohol induced dose dumping (AIDD)=== -- copy/pasted https://en.wikipedia.org/wiki/Alcohol_(drug)#Alcohol_induced_dose_dumping_(AIDD) |
>David Hedlund In vitro data suggest that some extended-release stimulants may experience dose dumping in the presence of alcohol =27467139 |
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====Alcohol induced dose dumping (AIDD)==== | ====Alcohol induced dose dumping (AIDD)==== | ||
This dose dumping effect is an unintended rapid release of large amounts of a given drug, when administered through a modified-release dosage while co-ingesting ethanol.<ref>{{Cite journal | vauthors = D'Souza S, Mayock S, Salt A |date=December 2017 |title=A review of in vivo and in vitro aspects of alcohol-induced dose dumping |journal=AAPS Open |language=en |volume=3 |issue=1 |doi=10.1186/s41120-017-0014-9 |issn=2364-9534|doi-access=free }}</ref> This is considered a pharmaceutical disadvantage due to the high risk of causing drug-induced toxicity by increasing the absorption and serum concentration above the therapeutic window of the drug. The best way to prevent this interaction is by avoiding the co-ingestion of both substances or using specific controlled-release formulations that are resistant to AIDD. | This dose dumping effect is an unintended rapid release of large amounts of a given drug, when administered through a modified-release dosage while co-ingesting ethanol.<ref>{{Cite journal | vauthors = D'Souza S, Mayock S, Salt A |date=December 2017 |title=A review of in vivo and in vitro aspects of alcohol-induced dose dumping |journal=AAPS Open |language=en |volume=3 |issue=1 |doi=10.1186/s41120-017-0014-9 |issn=2364-9534|doi-access=free }}</ref> This is considered a pharmaceutical disadvantage due to the high risk of causing drug-induced toxicity by increasing the absorption and serum concentration above the therapeutic window of the drug. The best way to prevent this interaction is by avoiding the co-ingestion of both substances or using specific controlled-release formulations that are resistant to AIDD. | ||
In vitro data suggest that some extended-release stimulants may experience dose dumping in the presence of alcohol. This is a concern because the ADHD patient population is at risk for alcohol abuse. The potential for dose dumping when taking extended-release stimulants with alcohol could lead to unintended and dangerous side effects for those with ADHD.<ref>{{cite journal |last1=Jain |first1=R |last2=Stark |first2=JG |title=Safety and efficacy considerations due to misuse of extended-release formulations of stimulant medications. |journal=Postgraduate medicine |date=September 2016 |volume=128 |issue=7 |pages=672-81 |doi=10.1080/00325481.2016.1218259 |pmid=27467139}}</ref> | |||
===Dangerous interactions=== | ===Dangerous interactions=== | ||