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Unique substance warnings: Difference between revisions
>David Hedlund m |
>David Hedlund * Nitrous oxide: ''Nitrous oxide causes an acute increase in plasma homocysteine that is more pronounced in patients with the methylenetetrahydrofolate reductase (MTHFR) C677T or A1298C gene variant.''.<ref>https://pubmed.ncbi.nlm.nih.gov/23856660/</ref> |
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===Genotype=== | ===Genotype=== | ||
* [[MDMA]]: There is a small percentage of people, who due to their race and family history, have a lower level of the liver enzyme P450 2D6. This can cause them to be more sensitive to MDMA, requiring lower doses and extra caution should be taken.<ref>http://www.erowid.org/chemicals/mdma/mdma_basics.shtml</ref> | * [[MDMA]]: There is a small percentage of people, who due to their race and family history, have a lower level of the liver enzyme P450 2D6. This can cause them to be more sensitive to MDMA, requiring lower doses and extra caution should be taken.<ref>http://www.erowid.org/chemicals/mdma/mdma_basics.shtml</ref> | ||
* [[Nitrous oxide]]: ''Nitrous oxide causes an acute increase in plasma homocysteine that is more pronounced in patients with the methylenetetrahydrofolate reductase (MTHFR) C677T or A1298C gene variant.''.<ref>https://pubmed.ncbi.nlm.nih.gov/23856660/</ref> | |||
* [[THC]]: ''CYP2C9'' genotype affects THC sensitivity significantly: ''Subjects with the *3/*3 genotype had 3-fold higher THC levels in their blood than subjects with the *1/*1 genotype. Those subjects with one copy of each gene (*1/*3) had intermediate THC levels that were about 2-fold higher than subjects with *1/*1.''<ref>https://www.ncbi.nlm.nih.gov/books/NBK564166/</ref> | * [[THC]]: ''CYP2C9'' genotype affects THC sensitivity significantly: ''Subjects with the *3/*3 genotype had 3-fold higher THC levels in their blood than subjects with the *1/*1 genotype. Those subjects with one copy of each gene (*1/*3) had intermediate THC levels that were about 2-fold higher than subjects with *1/*1.''<ref>https://www.ncbi.nlm.nih.gov/books/NBK564166/</ref> | ||
==References== | ==References== | ||
{{reflist}} | {{reflist}} | ||