4F-MPH: Difference between revisions

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The two substances are believed to have very similar pharmacological mechanisms as [[monoamine]] [[reuptake inhibitors]] but have been reported to display distinctive [[subjective effects index|subjective effects]], with 4F-MPH being considered significantly more euphoric and recreational. Anecdotal reports suggest that it is considerably more potent with fewer uncomfortable side effects such as [[anxiety]], [[muscle spasms]] and [[compulsive redosing]].<ref>http://www.bluelight.org/vb/threads/770658-4-Fluoromethylphenidate-(4F-MPH)</ref> This perhaps owes to the fact that it has been shown to act as a higher efficiency [[dopamine]] reuptake inhibitor than the parent compound methylphenidate.<ref>{{cite journal | vauthors=((Deutsch, H. M.)), ((Shi, Q.)), ((Gruszecka-Kowalik, E.)), ((Schweri, M. M.)) | journal=Journal of Medicinal Chemistry | title=Synthesis and Pharmacology of Potential Cocaine Antagonists. 2. Structure−Activity Relationship Studies of Aromatic Ring-Substituted Methylphenidate Analogs | volume=39 | issue=6 | pages=1201–1209 | date=15 March 1996 | url=https://pubs.acs.org/doi/10.1021/jm950697c | issn=0022-2623 | doi=10.1021/jm950697c}}</ref><ref>{{cite journal | vauthors=((Schweri, M. M.)), ((Deutsch, H. M.)), ((Massey, A. T.)), ((Holtzman, S. G.)) | journal=The Journal of Pharmacology and Experimental Therapeutics | title=Biochemical and behavioral characterization of novel methylphenidate analogs | volume=301 | issue=2 | pages=527–535 | date= May 2002 | issn=0022-3565 | doi=10.1124/jpet.301.2.527}}</ref><ref>{{cite journal | vauthors=((Davies, H. M. L.)), ((Hopper, D. W.)), ((Hansen, T.)), ((Liu, Q.)), ((Childers, S. R.)) | journal=Bioorganic & Medicinal Chemistry Letters | title=Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites | volume=14 | issue=7 | pages=1799–1802 | date=5 April 2004 | issn=0960-894X | doi=10.1016/j.bmcl.2003.12.097}}</ref><ref>{{cite journal | vauthors=((Misra, M.)), ((Shi, Q.)), ((Ye, X.)), ((Gruszecka-Kowalik, E.)), ((Bu, W.)), ((Liu, Z.)), ((Schweri, M. M.)), ((Deutsch, H. M.)), ((Venanzi, C. A.)) | journal=Bioorganic & Medicinal Chemistry | title=Quantitative structure-activity relationship studies of threo-methylphenidate analogs | volume=18 | issue=20 | pages=7221–7238 | date=15 October 2010 | issn=1464-3391 | doi=10.1016/j.bmc.2010.08.034}}</ref><ref>{{cite journal | vauthors=((Singh, S.)) | journal=Chemical Reviews | title=Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists | volume=100 | issue=3 | pages=925–1024 | date=1 March 2000 | url=https://pubs.acs.org/doi/10.1021/cr9700538 | issn=0009-2665 | doi=10.1021/cr9700538}}</ref>

4F-MPH has an extremely short history of [[recreational drug use|recreational use]] and has ~~yet to be~~ documented ~~being sold~~ on the streets. It was initially developed as a replacement for [[ethylphenidate]] which became illegal in the United Kingdom on April 2015 following a temporary blanket ban. Shortly after, it became available for sale on the online gray market as a [[research chemical]] for global distribution.

4F-MPH has an extremely short history of [[recreational drug use|recreational use]] and has only once been documented on the streets on September 22nd when a sample was sent in to Wedinos which a drug testing service in the United Kingdom with the purchase intent being Cocaine. It was initially developed as a replacement for [[ethylphenidate]] which became illegal in the United Kingdom on April 2015 following a temporary blanket ban. Shortly after, it became available for sale on the online gray market as a [[research chemical]] for global distribution.

Due to its potent, long-lasting stimulant effect, likely habit-forming properties as well as unknown toxicity profile, it is strongly recommended that one use proper [[harm reduction]] practices if choosing to use this substance.

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 The two substances are believed to have very similar pharmacological mechanisms as [[monoamine]] [[reuptake inhibitors]] but have been reported to display distinctive [[subjective effects index|subjective effects]], with 4F-MPH being considered significantly more euphoric and recreational. Anecdotal reports suggest that it is considerably more potent with fewer uncomfortable side effects such as [[anxiety]], [[muscle spasms]] and [[compulsive redosing]].<ref>http://www.bluelight.org/vb/threads/770658-4-Fluoromethylphenidate-(4F-MPH)</ref> This perhaps owes to the fact that it has been shown to act as a higher efficiency [[dopamine]] reuptake inhibitor than the parent compound methylphenidate.<ref>{{cite journal | vauthors=((Deutsch, H. M.)), ((Shi, Q.)), ((Gruszecka-Kowalik, E.)), ((Schweri, M. M.)) | journal=Journal of Medicinal Chemistry | title=Synthesis and Pharmacology of Potential Cocaine Antagonists. 2. Structure−Activity Relationship Studies of Aromatic Ring-Substituted Methylphenidate Analogs | volume=39 | issue=6 | pages=1201–1209 | date=15 March 1996 | url=https://pubs.acs.org/doi/10.1021/jm950697c | issn=0022-2623 | doi=10.1021/jm950697c}}</ref><ref>{{cite journal | vauthors=((Schweri, M. M.)), ((Deutsch, H. M.)), ((Massey, A. T.)), ((Holtzman, S. G.)) | journal=The Journal of Pharmacology and Experimental Therapeutics | title=Biochemical and behavioral characterization of novel methylphenidate analogs | volume=301 | issue=2 | pages=527–535 | date= May 2002 | issn=0022-3565 | doi=10.1124/jpet.301.2.527}}</ref><ref>{{cite journal | vauthors=((Davies, H. M. L.)), ((Hopper, D. W.)), ((Hansen, T.)), ((Liu, Q.)), ((Childers, S. R.)) | journal=Bioorganic & Medicinal Chemistry Letters | title=Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites | volume=14 | issue=7 | pages=1799–1802 | date=5 April 2004 | issn=0960-894X | doi=10.1016/j.bmcl.2003.12.097}}</ref><ref>{{cite journal | vauthors=((Misra, M.)), ((Shi, Q.)), ((Ye, X.)), ((Gruszecka-Kowalik, E.)), ((Bu, W.)), ((Liu, Z.)), ((Schweri, M. M.)), ((Deutsch, H. M.)), ((Venanzi, C. A.)) | journal=Bioorganic & Medicinal Chemistry | title=Quantitative structure-activity relationship studies of threo-methylphenidate analogs | volume=18 | issue=20 | pages=7221–7238 | date=15 October 2010 | issn=1464-3391 | doi=10.1016/j.bmc.2010.08.034}}</ref><ref>{{cite journal | vauthors=((Singh, S.)) | journal=Chemical Reviews | title=Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists | volume=100 | issue=3 | pages=925–1024 | date=1 March 2000 | url=https://pubs.acs.org/doi/10.1021/cr9700538 | issn=0009-2665 | doi=10.1021/cr9700538}}</ref>
-F-MPH has an extremely short history of [[recreational drug use|recreational use]] and has yet to be documented being sold on the streets. It was initially developed as a replacement for [[ethylphenidate]] which became illegal in the United Kingdom on April 2015 following a temporary blanket ban. Shortly after, it became available for sale on the online gray market as a [[research chemical]] for global distribution.
+F-MPH has an extremely short history of [[recreational drug use|recreational use]] and has only once been documented on the streets on September 22nd when a sample was sent in to Wedinos which a drug testing service in the United Kingdom with the purchase intent being Cocaine. It was initially developed as a replacement for [[ethylphenidate]] which became illegal in the United Kingdom on April 2015 following a temporary blanket ban. Shortly after, it became available for sale on the online gray market as a [[research chemical]] for global distribution.
 Due to its potent, long-lasting stimulant effect, likely habit-forming properties as well as unknown toxicity profile, it is strongly recommended that one use proper [[harm reduction]] practices if choosing to use this substance.