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Anxiety suppression: Difference between revisions
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'''Anxiety suppression''' (also known as '''anxiolysis''' or '''minimal sedation''')<ref>{{Citation | title=anxiolysis | publisher=National Cancer Institute | url=https://www.cancer.gov/publications/dictionaries/cancer-terms/def/anxiolysis}}</ref> is medically recognized as a partial to complete suppression of a person’s ability to feel anxiety, general unease, and negative feelings of both psychological and physiological tension.<ref name="Gordon2002">{{cite journal|last1=Gordon|first1=Joshua A.|title=Anxiolytic drug targets: beyond the usual suspects|journal=Journal of Clinical Investigation|volume=110|issue=7|year=2002|pages=915–917|issn=0021-9738|doi=10.1172/JCI0216846}}</ref> The experience of this effect may decrease anxiety-related behaviours such as restlessness, muscular tension,<ref>{{cite journal | vauthors=((Tyrer, P.)) | journal=BMJ | title=Prescribing psychotropic drugs in general practice | volume=296 | issue=6622 | pages=588–589 | date=27 February 1988 | url=https://www.bmj.com/lookup/doi/10.1136/bmj.296.6622.588 | doi=10.1136/bmj.296.6622.588}}</ref> rumination, and panic attacks. | '''Anxiety suppression''' (also known as '''anxiolysis''' or '''minimal sedation''')<ref>{{Citation | title=anxiolysis | publisher=National Cancer Institute | url=https://www.cancer.gov/publications/dictionaries/cancer-terms/def/anxiolysis}}</ref> is medically recognized as a partial to complete suppression of a person’s ability to feel anxiety, general unease, and negative feelings of both psychological and physiological tension.<ref name="Gordon2002">{{cite journal|last1=Gordon|first1=Joshua A.|title=Anxiolytic drug targets: beyond the usual suspects|journal=Journal of Clinical Investigation|volume=110|issue=7|year=2002|pages=915–917|issn=0021-9738|doi=10.1172/JCI0216846}}</ref> The experience of this effect may decrease anxiety-related behaviours such as restlessness, muscular tension,<ref>{{cite journal | vauthors=((Tyrer, P.)) | journal=BMJ | title=Prescribing psychotropic drugs in general practice | volume=296 | issue=6622 | pages=588–589 | date=27 February 1988 | url=https://www.bmj.com/lookup/doi/10.1136/bmj.296.6622.588 | doi=10.1136/bmj.296.6622.588}}</ref> rumination, and panic attacks. Complete anxiety suppression can produce feelings of extreme calmness and relaxation; however, it can also lead to undesirable outcomes when accompanied by other effects such as [[disinhibition]] or [[sedation]]. | ||
It is most commonly induced under the influence of [[dosage#common|moderate]] [[dosage|dosages]] of [[anxiolytic]] compounds which primarily include [[GABAergic]] [[depressant|depressants]],<ref>{{cite journal | vauthors=((Lydiard, R. B.)) | journal=The Journal of Clinical Psychiatry | title=The role of GABA in anxiety disorders | volume=64 Suppl 3 | pages=21–27 | date= 2003 | issn=0160-6689}}</ref><ref name="GauthierNuss2015">{{cite journal|last1=Gauthier|first1=Isabelle|last2=Nuss|first2=Philippe|title=Anxiety disorders and GABA neurotransmission: a disturbance of modulation|journal=Neuropsychiatric Disease and Treatment|year=2015|pages=165|issn=1178-2021|doi=10.2147/NDT.S58841}}</ref> such as [[benzodiazepine|benzodiazepines]],<ref name="WoodShader1993">{{cite journal|last1=Wood|first1=Alastair J.J.|last2=Shader|first2=Richard I.|last3=Greenblatt|first3=David J.|title=Use of Benzodiazepines in Anxiety Disorders|journal=New England Journal of Medicine|volume=328|issue=19|year=1993|pages=1398–1405|issn=0028-4793|doi=10.1056/NEJM199305133281907}}</ref> [[alcohol]],<ref>{{cite journal | vauthors=((Smith, J. P.)), ((Randall, C. L.)) | journal=Alcohol Research: Current Reviews | title=Anxiety and alcohol use disorders: comorbidity and treatment considerations | volume=34 | issue=4 | pages=414–431 | date= 2012 | issn=2168-3492}}</ref> [[GHB]],<ref name="Schmidt-MutterPain1998">{{cite journal|last1=Schmidt-Mutter|first1=Catherine|last2=Pain|first2=Laure|last3=Sandner|first3=Guy|last4=Gobaille|first4=Serge|last5=Maitre|first5=Michel|title=The anxiolytic effect of γ-hydroxybutyrate in the elevated plus maze is reversed by the benzodiazepine receptor antagonist, flumazenil|journal=European Journal of Pharmacology|volume=342|issue=1|year=1998|pages=21–27|issn=00142999|doi=10.1016/S0014-2999(97)01503-3}}</ref> and [[gabapentinoid|gabapentinoids]]<ref name="PollackMatthews1998">{{cite journal|last1=Pollack|first1=Mark H.|last2=Matthews|first2=John|last3=Scott|first3=Erin L.|title=Gabapentin as a Potential Treatment for Anxiety Disorders|journal=American Journal of Psychiatry|volume=155|issue=7|year=1998|pages=992–993|issn=0002-953X|doi=10.1176/ajp.155.7.992}}</ref>. However, it can also occur to a lesser extent under the influence of a large variety of other pharmacological classes which include but are not limited to [[Cannabinoid|cannabinoids]],<ref name="BlessingSteenkamp20152">{{cite journal|last1=Blessing|first1=Esther M.|last2=Steenkamp|first2=Maria M.|last3=Manzanares|first3=Jorge|last4=Marmar|first4=Charles R.|title=Cannabidiol as a Potential Treatment for Anxiety Disorders|journal=Neurotherapeutics|volume=12|issue=4|year=2015|pages=825–836|issn=1933-7213|doi=10.1007/s13311-015-0387-1}}</ref> [[dissociative|dissociatives]],<ref name="IrwinIglewicz2010">{{cite journal|last1=Irwin|first1=Scott A.|last2=Iglewicz|first2=Alana|title=Oral Ketamine for the Rapid Treatment of Depression and Anxiety in Patients Receiving Hospice Care|journal=Journal of Palliative Medicine|volume=13|issue=7|year=2010|pages=903–908|issn=1096-6218|doi=10.1089/jpm.2010.9808}}</ref> [[SSRI|SSRIs]], and [[opioid|opioids]]. | |||
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===Psychoactive substances=== | ===Psychoactive substances=== | ||
Compounds within our [[psychoactive substance index]] which may cause this effect include: | Compounds within our [[psychoactive substance index]] which may cause this effect include: | ||
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{{#ask:[[Category:Experience]][[Effect::Anxiety suppression]]|format=ul|Columns=1}} | {{#ask:[[Category:Experience]][[Effect::Anxiety suppression]]|format=ul|Columns=1}} | ||
===See also=== | ===See also=== | ||
*[[Responsible use]] | *[[Responsible use]] | ||
*[[Subjective effects index]] | *[[Subjective effects index]] | ||
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*[[Dissociatives#Subjective_effects|Dissociatives - Subjective effects]] | *[[Dissociatives#Subjective_effects|Dissociatives - Subjective effects]] | ||
*[[Deliriants#Subjective_effects|Deliriants - Subjective effects]] | *[[Deliriants#Subjective_effects|Deliriants - Subjective effects]] | ||
===External links=== | ===External links=== | ||
* [https://en.wikipedia.org/wiki/Anxiety Anxiety (Wikipedia)] | |||
* [https://en.wikipedia.org/wiki/Anxiolytic Anxiolytic (Wikipedia)] | *[https://en.wikipedia.org/wiki/Anxiety Anxiety (Wikipedia)] | ||
*[https://en.wikipedia.org/wiki/Anxiolytic Anxiolytic (Wikipedia)] | |||
===References=== | ===References=== | ||
<references /> | <references /> | ||